Cefadroxil hydrate  (Synonyms: 头孢羟氨苄一水合物; BL-S 578 hydrate)

Cefadroxil hydrate is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil hydrate inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil hydrate is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil hydrate has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain^{[1][2][3][4][5][6][7]}.

Cefadroxil hydrate 对大多数革兰氏阳性和革兰氏阴性菌的抑制活性与 Cephalexin (HY-B0200) 和 Cephradine (HY-B1156) 相似，但对化脓性链球菌的活性是 Cephalexin 的两倍^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefadroxil (25-200 mg/kg；口服) hydrate 在25和100 mg/kg剂量下达到的血药峰浓度与 Cephalexin 相似^[1]。
Cefadroxil (150 mg/kg；口服) hydrate 对大鼠和小鼠的保留神经损伤 (SNI) 模型中的机械性异常疼痛具有镇痛作用，对小鼠的冷痛也具有镇痛作用^[4]。
Cefadroxil (0.39-100 mg/kg；口服；单次或 24、27、30 h 三次) hydrate 在大鼠链球菌性肺炎模型中，疗效优于 Cephalexin，肺组织中 AUC 更大，半衰期更长^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

381.40

C₁₆H₁₉N₃O₆S

66592-87-8

固体

White to off-white

头孢羟氨苄一水合物

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Buck RE, et al. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324-30.  [Content Brief]

  [2]. Posada MM, et al. Relevance of PepT1 in the intestinal permeability and oral absorption of cefadroxil. Pharm Res. 2013 Apr;30(4):1017-25.  [Content Brief]

  [3]. Hu Y, et al. Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice. Biochem Pharmacol. 2016 May 1;107:81-90.  [Content Brief]

  [4]. Han CJ, et al. Antinociceptive effects of cefadroxil and ceftriaxone in experimental animal models of pain. Neuro Endocrinol Lett. 2023 Jul 28;44(5):309-320.  [Content Brief]

  [5]. Tan Z, et al. Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration-Time Profile at Infected Tissue. Front Pharmacol. 2021 Dec 23;12:692741.  [Content Brief]

  [6]. Chisholm DR, et al. Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model. Antimicrob Agents Chemother. 1986 Jul;30(1):105-9.  [Content Brief]

  [7]. Chen X, et al. Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study. Biochem Pharmacol. 2017 May 1;131:89-97.  [Content Brief]