2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase COX
  4. COX-2/15-LOX-IN-4

COX-2/15-LOX-IN-4 (compound 5i) 是 COX-2/15-LOX 的双抑制剂，IC50s 分别为 0.075 μM 和 1.97 μM。COX-2/15-LOX-IN-4 能够抑制 LPS 诱导细胞产生促进细胞因子 (IL-6, ROS)，具体抗炎活性。

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COX-2/15-LOX-IN-4 Chemical Structure

COX-2/15-LOX-IN-4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

COX-2/15-LOX-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-4 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS) with specific anti-inflammatory activity[1].

IC50 & Target

IC50: 0.075 μM (COX-2), 11.43 μM (COX-1), 1.97 μM (15-LOX)[1]
体外研究
(In Vitro)

COX-2/15-LOX-IN-4 (compound 5i) decreases LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) in RAW 264.7 macrophage cell line, with IC50s of 7.48 μM and 37.54 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COX-2/15-LOX-IN-4 相关抗体:
分子量

405.49

Formula

C23H20FN3OS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

COX-2/15-LOX-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/15-LOX-IN-4LipoxygenaseCOXLOXCyclooxygenaseAntioxidantDual COX-2/15-LOX inhibitorsHeterodimerInflammationThienopyrimidineInhibitorinhibitorinhibit

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