2. Metabolic Enzyme/Protease NF-κB Apoptosis Cytoskeleton Cell Cycle/DNA Damage
  3. Endogenous Metabolite NF-κB TNF Receptor FOXO Microtubule/Tubulin
  4. D-chiro-Inositol

D-chiro-Inositol  (Synonyms: D-手性肌醇)

目录号: HY-N3021 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

D-chiro-Inositol 是一种肌醇的差向异构体，具有改善糖代谢、抗肿瘤、抗炎和抗氧化的活性。D-chiro-Inositol 通过改善胆汁酸分泌和减轻氧化应激，有效缓解胆汁淤积。它通过模拟胰岛素的作用来改善胰岛素抵抗，降低高血糖和循环胰岛素水平，减少血清雄激素，并改善 X 综合征的一些代谢异常。此外，D-chiro-Inositol 可诱导促炎因子 (如 Nf-κB) 和细胞因子 (如 TNF-α) 的减少，从而发挥抗炎作用。D-chiro-Inositol 可用于肝硬化、乳腺癌、2 型糖尿病和多囊卵巢综合征的研究。

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D-chiro-Inositol Chemical Structure

D-chiro-Inositol Chemical Structure

CAS No. : 643-12-9

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5 mg ￥187
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10 mg ￥300
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50 mg ￥500
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Customer Review

D-chiro-Inositol 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D-chiro-Inositol is a stereoisomer of inositol that exhibits activities such as improving glucose metabolism, anti-tumor effects, anti-inflammatory properties, and antioxidant activity. D-chiro-Inositol effectively alleviates cholestasis by enhancing bile acid secretion and reducing oxidative stress. D-chiro-Inositol improves insulin resistance, lowers hyperglycemia and circulating insulin levels, reduces serum androgen levels, and ameliorates some metabolic abnormalities associated with X syndrome by mimicking the action of insulin. Additionally, D-chiro-Inositol can induce a reduction in pro-inflammatory factors (such as Nf-κB) and cytokines (such as TNF-α), thereby exerting anti-inflammatory effects. D-chiro-Inositol may be used in the study of liver cirrhosis, breast cancer, type 2 diabetes, and polycystic ovary syndrome[1][2][3][4][5][6][7][8][9].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

D-chiro-Inositol (0.1-10 μmol, 3 h) 改善 Palmitoleic acid (HY-W011873) 处理的 HepG2 细胞的糖代谢，抑制了 FOXO1 的活性[3]。
D-chiro-Inositol (1-40 mM, 48 h) 抑制了乳腺癌细胞 MDA-MB-231 的生长[4]。
D-chiro-Inositol (0.125-1 mM, 24 和 48 h) 可调节 3T3-L1 脂肪细胞的 GSH/GSSG 比值，降低细胞的促炎状态[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D-chiro-Inositol 相关抗体:

Real Time qPCR[3]

Cell Line: PA-treated HepG2 cells
Concentration: 0.1-10 μmol
Incubation Time: 3 h
Result: Increased the mRNA expression levels of PEPCK and G6 Pase in HepG2 cells.

Western Blot Analysis[3]

Cell Line: PA-treated HepG2 cells
Concentration: 0.1-10 μmol
Incubation Time: 3 h
Result: Inhibited the downregulation of IR β and p85 subunit expression levels and restored the phosphorylation levels of IRS-2, AKT and FOXO1.

Cell Proliferation Assay[4]

Cell Line: MDA-MB-231 cells
Concentration: 1, 5, 10, 20 and 40 mM
Incubation Time: 48 h
Result: The cell proliferation abilities decreased by 18.3%, 17.2%, 17.5%, 18.4% and 24.9%, respectively.
体内研究
(In Vivo)

D-chiro-Inositol (150 mg/kg; p.o.; 每天 1 次持续 2 周) 减轻胆汁淤积模型大鼠的肝脏胆汁酸积累，降低肝脏损伤和纤维化的严重程度[2]。
D-chiro-Inositol (50 mg/kg; i,g.; 每天 1 次持续 8 周) 增强高脂肪饮食小鼠葡萄糖耐量，降低肝脏中脂质积累[3]。
D-chiro-Inositol (500 和 1000 mg/kg; p.o.; 每天 1 次持续 45 天) 抑制小鼠异种移植瘤模型中肿瘤的生长[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of cholestasis induced by bile duct ligation [2]
Dosage: 150 mg/kg
Administration: Oral gavage (p.o.) Once a day for 2 weeks
Result: Reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in rats, and alleviates bile duct hyperplasia, parenchymal necrosis and fibrosis.
Increased total bile acid (TBA) levels in serum and bile and decreased total bile acid (TBA) levels in the liver.
Increased the expression of genes encoding bile acid transporters BSEP (Abcb11) and MRP2 (Abcc2) in liver tissue.
Decreased liver CD68 and NF-κB levels, serum and liver MDA levels, and significantly increased serum and liver superoxide dismutase activity.
Animal Model: High-fat diet mice [3]
Dosage: 50 mg/kg
Administration: i.g.; once a day for 8 weeks
Result: Reduces hepatic DAG production and prevents PKCε ectopic translocation to the membrane, thereby inhibiting PKCε activation.
Increased the low levels of IRβ and PI3Kp85 and reversed the downregulation of IRS-2 and AKT phosphorylation levels.
Animal Model: Female nude mice xenograft tumor model[4]
Dosage: 500 和 1000 mg/kg
Administration: p.o.; once a day for 45 days
Result: The tumor growth inhibition rates were 22.1% and 67.6%, respectively.
分子量

180.16

Formula

C6H12O6
CAS 号
性状

固体

颜色

White to off-white

中文名称

D-手性肌醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 75 mg/mL (416.30 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (555.06 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (291 KB) HNMR (224 KB)

产品使用指南 (1538 KB)
参考文献

D-chiro-Inositol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5506 mL 27.7531 mL 55.5062 mL 138.7655 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
15 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
20 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
25 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
30 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
40 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
50 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
60 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
80 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-chiro-Inositol643-12-9D-手性肌醇Endogenous MetaboliteNF-κBTNF ReceptorFOXOMicrotubule/TubulinNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRForkhead box OInhibitorinhibitorinhibit

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