2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation GPCR/G Protein
  3. Radionuclide-Drug Conjugates (RDCs) CXCR
  4. DOTA Conjugated JM#21 derivative 7

DOTA Conjugated JM#21 derivative 7 (compound Ligand-7) 是 CXCR4 靶向肽与 DOTA 结合的衍生物，可用于生产放射性配体。放射性标记的 DOTA Conjugated JM#21 derivative 7，即 177Lu-DOTA，具有优异的 CXCR4 肿瘤靶向性。177Lu-DOTA 的体外生物分布结果显示，其在除肾脏外所有非靶向器官的摄取量都非常低。DOTA Conjugated JM#21 derivative 7 可用于放射性核素偶联药物 (RDC) 的合成/研究。

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DOTA Conjugated JM#21 derivative 7 Chemical Structure

DOTA Conjugated JM#21 derivative 7 Chemical Structure

CAS No. : 3033865-40-3

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DOTA Conjugated JM#21 derivative 7 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DOTA Conjugated JM#21 derivative 7 (compound Ligand-7) is a derivative of CXCR4 targeting peptide conjugated with DOTA and can be used to produce radioligands. Radiolabeled DOTA Conjugated JM#21 derivative 7, i.e., 177Lu-DOTA, has excellent CXCR4 tumor targeting. In vitro biodistribution results of 177Lu-DOTA showed very low uptake in all non-targeted organs except kidney[1]. DOTA Conjugated JM#21 derivative 7 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC50 & Target

RDC Peptide

 

分子量

1471.75

Formula

C66H114N22O16
CAS 号
Sequence

{d-Ile}-LRWSRK-Lys(DOTA)-NH2
Sequence Shortening

{d-Ile}-Leu-Arg-Trp-Ser-Arg-Lys-Lys(DOTA)-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DOTA Conjugated JM#21 derivative 7 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA Conjugated JM#21 derivative 73033865-40-3Radionuclide-Drug Conjugates (RDCs)CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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