2. Gene
  3. CYP2A6 - cytochrome P450 family 2 subfamily A member 6 Gene

CYP2A6 - cytochrome P450 family 2 subfamily A member 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：细胞色素 P450 家族 2 亚家族 A 成员 6

种属: Homo sapiens

同用名: CPA6; CYP2A; CYP2A3; P450PB; CYPIIA6; P450C2A

基因 ID: 1548 | 基因类型: protein coding

关于 CYP2A6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,843,541-40,850,447 (from NCBI)

This gene has 4 transcripts (splice variants), 117 orthologues, 15 paralogues and is associated with 5 phenotypes. Restricted expression toward liver (RPKM 542.0).

功能概要

该基因 CYP2A6 编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。该蛋白质定位于内质网，其表达由苯巴比妥诱导。已知该酶可以羟基化香豆素，还可以代谢尼古丁、黄曲霉毒素 B1、亚硝胺和一些药物。具有某些等位基因变异的个体据说具有较差的代谢表型，这意味着他们不能有效地代谢香豆素或尼古丁。该基因是来自 19q 染色体上 CYP2A、CYP2B 和 CYP2F 亚家族的一大群细胞色素 P450 基因的一部分。该基因以前称为 CYP2A3；但是，它已更名为 CYP2A6。[RefSeq 提供，2008 年 7 月]

This gene, CYP2A6, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The Enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of Cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]

CYP2A6 基因产物(1)

mRNA Protein Name
NM_000762.6 NP_000753.3 cytochrome P450 2A6 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coumarin 7-hydroxylase activity IDA
IDA: 通过直接分析推断
16086027 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
15680923 GOA
enables heme binding IDA
IDA: 通过直接分析推断
16086027 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in coumarin catabolic process IDA
IDA: 通过直接分析推断
19029318 GOA
involved in coumarin metabolic process IDA
IDA: 通过直接分析推断
19651758 GOA
involved in steroid metabolic process IMP
IMP: 通过突变表型推断
18356043 GOA
involved in xenobiotic catabolic process IDA
IDA: 通过直接分析推断
15680923 GOA
involved in xenobiotic metabolic process IDA
IDA: 通过直接分析推断
19651758 GOA
involved in xenobiotic metabolic process IMP
IMP: 通过突变表型推断
18356043 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic microtubule IDA
IDA: 通过直接分析推断
23264731 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYP2A6 蛋白结构

p450

p450: Cytochrome P450 (34 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
蛋白主名 其他名称

cytochrome P450 2A6

1,4-cineole 2-exo-monooxygenase

CYP2A6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CYP2A6 P11509 RABAC1 Homo sapiens Q9UI14
Anti Tag CoIP
33961781
种属内
CYP2A6 P11509 RABAC1 Homo sapiens Q9UI14
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome
Coumarin Resistance

Warfarin Resistance

Warfarin Sensitivity

Coumadin Sensitivity

Warfarin Response

Poor Metabolism Of Coumarin

Coumarin, Poor Metabolism Of

CMRES
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Letrozole Toxicity
Acetaminophen Metabolism
Liver Cirrhosis

Cirrhosis

Cirrhosis Of Liver

CIRRH

Cryptogenic Cirrhosis

Cirrhosis, Cryptogenic

Cirrhosis Nos
Substance Dependence
Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis

Portal Cirrhosis

Alcoholic Cirrhosis Of Liver

Liver Cirrhosis, Alcoholic

Laennec'S Cirrhosis

Laennec'S Cirrhosis, Alcoholic

Alcohol Cirrhosis

Alcoholic Laennec Cirrhosis

Alcoholic Cirrhosis Nos

Etoh Cirrhosis

Alcohol Hepatic Cirrhosis

Alcohol Liver Cirrhosis

Laennec Cirrhosis
Tinea Cruris

Dermatophytosis Of Groin & Perianal Area

Dermatophytosis Of Groin And Perianal Area

Dhobie Itch

Tinea Of Perianal Region
Lung Adenoma

Adenoma Of Lung

Pulmonary Adenoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17356 Fenofibrate 99.93% 是
HY-B0365A Memantine hydrochloride ≥98.00% 否
HY-17459 Clopidogrel hydrogen sulfate Inhibitor 99.43% 是
HY-B1184 Mephenytoin 99.96% 否
HY-17459R Clopidogrel (hydrogen sulfate) (Standard) Inhibitor / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-129105 Clomethiazole 99.75% Phase 3
HY-12946 BI 653048 Inhibitor 99.84% Phase 1
HY-12946A BI 653048 phosphate Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (100)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0904 Ginsenoside C-K Inhibitor 99.92% 否
HY-N0494 Gentiopicroside Inhibitor 99.83% 否
HY-N0043 Ginsenoside Rd Inhibitor 99.88% 否
HY-W008364 Olivetol Inhibitor 99.81% 否
HY-105124 Bufuralol Antagonist 99.17% 否
HY-100637 Hydroxybupropion 99.91% 否
HY-W011235 Norfluoxetine hydrochloride Inhibitor 99.58% 否
HY-117026 LKY-047 Inhibitor 99.94% 否
HY-N2425 Rhodiosin Inhibitor 99.36% 否
HY-N0598 Ginsenoside F1 Inhibitor ≥99.0% 否
HY-100665 Dehydroaripiprazole Agonist 99.66% 否
HY-N2260 Cephaeline dihydrochloride Inhibitor 99.84% 否
HY-135331 N-Desmethyl-Apalutamide 99.68% 否
HY-N5132 (-)-Fenchone ≥98.0% 否
HY-14362 GSK-25 Inhibitor 99.68% 否
HY-105124A Bufuralol hydrochloride Antagonist ≥99.0% 否
HY-W040468 2-Phenyl-2-(1-piperidinyl)propane Inhibitor 99.81% 否
HY-16718 Dagrocorat 99.90% 否
HY-135560 Nicotelline Inhibitor 99.92% 否
HY-W010195 2,6-Dimethylquinoline Inhibitor 99.95% 否
HY-17356R Fenofibrate (Standard) 99.91% 否
HY-B1184S1 Mephenytoin-d5 98.72% 否
HY-100238 Antihistamine-1 Inhibitor 99.45% 否
HY-133116 4-Hydroxyatomoxetine 97.04% 否
HY-18063 ML252 Inhibitor 99.9% 否
HY-N2129 N-Nornuciferine Inhibitor 99.94% 否
HY-109054A O-Desmethyltramadol hydrochloride 97.64% 否
HY-135810A Cletoquine oxalate Inhibitor 99.76% 否
HY-16718A Dagrocorat hydrochloride 99.85% 否
HY-151239 ONT-993 Inhibitor 99.85% 否
HY-100064 O-Desmethyl gefitinib Inhibitor 99.40% 否
HY-109054 O-Demethyltramadol / 否
HY-133116S 4-Hydroxyatomoxetine-d3 98.89% 否
HY-B0352A (S)-Mirtazapine Antagonist 99.76% 否
HY-N1483 Guanfu base A Inhibitor 98.10% 否
HY-N8382 Chalepensin Inhibitor ≥98.0% 否
HY-W754151 N-Desmethyl apalutamide-d4 99.63% 否
HY-132428S O-Desmethyl Tramadol-d6 / 否
HY-170569 Cetagliptin / 否
HY-100064S O-Desmethyl gefitinib-d8 Inhibitor 99.84% 否
HY-100064S1 O-Desmethyl gefitinib-d6 Inhibitor / 否
HY-100665R Dehydroaripiprazole (Standard) Agonist / 否
HY-100665S Dehydroaripiprazole-d8 Agonist / 否
HY-10572A (R)-Efavirenz Inhibitor / 否
HY-110134 S07662 Inhibitor / 否
HY-112142A (Rac)-AB-423 Inhibitor / 否
HY-113575 Dehydroaripiprazole hydrochloride Agonist / 否
HY-135331S N-Desmethyl-Apalutamide-15N,d4 / 否
HY-135810 Cletoquine Inhibitor / 否
HY-135810S Cletoquine-d4 Inhibitor / 否
HY-135810S1 Cletoquine-d4-1 Inhibitor / 否
HY-144285 CXCR4 antagonist 4 Antagonist / 否
HY-144286 CXCR4 antagonist 3 Inhibitor / 否
HY-146177 CYP3A4 enzyme-IN-1 Inhibitor / 否
HY-147810 5-HT7 receptor ligand 1 / 否
HY-148597 FGFR-IN-10 Inhibitor / 否
HY-156330 HIV-IN-9 Inhibitor / 否
HY-159143 BChE-IN-33 Inhibitor / 否
HY-17356G Fenofibrate (GMP) / 否
HY-17356S Fenofibrate-d6 99.70% 否
HY-17356S1 Fenofibrate-d4 / 否
HY-17459S Clopidogrel-d3 hydrogen sulfate / 否
HY-B0352AS (S)-Mirtazapine-d3 Antagonist ≥99.0% 否
HY-B0365AS Memantine-d6 hydrochloride ≥98.0% 否
HY-B1184S2 Mephenytoin-d8 / 否
HY-E70461 Human CYP2D6,High-Reductase / 否
HY-E70465 Human CYP2A6,High-Reductase / 否
HY-E70467 Human CYP2D6,Low-Reductase / 否
HY-E70470 Human CYP2B6,Low-Reductase / 否
HY-E70474 Human CYP2B6,High-Reductase / 否
HY-E70488 Human CYP2B6,High-Reductase+b5 / 否
HY-E70504 Human CYP2B6,Low-Reductase+b5 / 否
HY-E70507 Human CYP2A6,High-Reductase+b5 / 否
HY-N0043R Ginsenoside Rd (Standard) Inhibitor / 否
HY-N0904R Ginsenoside C-K (Standard) Inhibitor / 否
HY-N11706 β-Cedrene Inhibitor / 否
HY-N1483A Guanfu base A hydrochloride Inhibitor / 否
HY-N3090 Peucedanol Inhibitor / 否
HY-N6023 Thermopsoside Inhibitor / 否
HY-N6989 Isoglycycoumarin / 否
HY-RS03454 CYP2A6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03456 CYP2B6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03461 CYP2D6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-109054AS O-Desmethyltramadol-d6 hydrochloride / 否
HY-131630 O-Desmethylmetoprolol / 否
HY-134664 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Inhibitor / 否
HY-155456 CYP2A6-IN-1 Inhibitor / 否
HY-169119 Antifungal agent 114 Inhibitor / 否
HY-17356S2 Fenofibrate-13C6 / 否
HY-18063A ML252 hydrochloride Inhibitor / 否
HY-24238 DLCI-1 Inhibitor / 否
HY-76569B 5-Hydroxymethyl tolterodine formate Antagonist / 否
HY-B1184S3 Mephenytoin-13C,d3 / 否
HY-W082430 CYP2A6-IN-2 Inhibitor / 否
HY-W587878 Thujopsene / 否
HY-W702646 Hydroxymethyl tolperisone hydrochloride Control / 否
HY-W740630 8-Hydroxy mirtazapine Control / 否
HY-W803860 N-Depropylpropafenone Antagonist / 否
HY-Z2493 Aripiprazole N1-oxide Control / 否
HY-Z9101 Promethazine sulfoxide Control / 否
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