Htr1a - 5-hydroxytryptamine (serotonin) receptor 1A Gene

中文名称：5-羟色胺 (血清素) 受体 1A

种属: Mus musculus

同用名: Gpcr18

关于 Htr1a

功能概要

该基因编码的蛋白可启动 G 蛋白偶联血清素受体活性。涉及多个过程，包括行为恐惧反应；血清素代谢过程；和血清素受体信号通路。作用于 γ-氨基丁酸信号通路的上游或内部。预测位于轴突岗。预计在树突中活跃。预计是质膜的组成部分。以多种结构表达，包括中枢神经系统；外分泌腺；眼睛;泌尿生殖系统；和肠道。用于研究焦虑症。该基因的人类直系同源物与焦虑症有关；精神抑郁症；和恐慌症。与人类 HTR1A（5-羟色胺受体 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; serotonin metabolic process; and serotonin receptor signaling pathway. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Predicted to be located in axon hillock. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]