2. Gene
  3. Tlr8 - toll-like receptor 8 Gene

Tlr8 - toll-like receptor 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Toll 样受体 8

种属: Mus musculus

基因 ID: 170744 | 基因类型: protein coding

关于 Tlr8

Chromosome X: 166,025,692-166,047,325 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 199 orthologues, 23 paralogues and is associated with 21 phenotypes. Low expression observed in reference dataset.

功能概要

预测该基因编码的蛋白具有相同的蛋白质结合活性；核酸结合活性；和模式识别受体活性。在蛋白质磷酸化的调节上游或调节内起作用。预计位于质膜外侧。预计在质膜上有活性。在脑和肝脏中表达。与人类 TLR8（toll 样受体 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Acts upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain and liver. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Tlr8 基因产物(3)

mRNA Protein Name
NM_001313760.1 NP_001300689.1 toll-like receptor 8 isoform 2 precursor
NM_133212.3 NP_573475.2 toll-like receptor 8 isoform 1 precursor
NM_001313761.1 NP_001300690.1 toll-like receptor 8 isoform 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26095358 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
24740015 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tlr8 蛋白结构

PRK15370

PRK15370: cl33128 (49 - 233)

LRR_RI

LRR_RI: sd00033 (64 - 87)

LRR_RI

LRR_RI: sd00033 (88 - 121)

LRR_RI

LRR_RI: sd00033 (122 - 142)

PLN00113

PLN00113: cl33413 (143 - 719)

LRR_RI

LRR_RI: sd00033 (143 - 166)

LRR_RI

LRR_RI: sd00033 (167 - 196)

LRR_RI

LRR_RI: sd00033 (197 - 217)

LRR_RI

LRR_RI: sd00033 (218 - 241)

LRR_RI

LRR_RI: sd00033 (242 - 282)

LRR_RI

LRR_RI: sd00033 (283 - 306)

LRR_RI

LRR_RI: sd00033 (307 - 326)

LRR_RI

LRR_RI: sd00033 (333 - 362)

LRR_RI

LRR_RI: sd00033 (363 - 389)

LRR_RI

LRR_RI: sd00033 (390 - 413)

LRR_RI

LRR_RI: sd00033 (464 - 496)

LRR_RI

LRR_RI: sd00033 (500 - 521)

LRR_RI

LRR_RI: sd00033 (522 - 545)

LRR_RI

LRR_RI: sd00033 (546 - 575)

LRR_RI

LRR_RI: sd00033 (576 - 599)

LRR_RI

LRR_RI: sd00033 (600 - 630)

LRR_RI

LRR_RI: sd00033 (631 - 655)

LRR_RI

LRR_RI: sd00033 (656 - 679)

LRR_RI

LRR_RI: sd00033 (680 - 703)

LRR_8

LRR_8: cl38440 (703 - 764)

LRR_RI

LRR_RI: sd00033 (704 - 727)

LRR_RI

LRR_RI: sd00033 (728 - 747)

TIR

TIR: smart00255 (870 - 1006)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1032 a.a.
蛋白主名 其他名称

toll-like receptor 8

相关产品

Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.80% Phase 2
HY-13773 Motolimod Agonist 98.12% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.33% Phase 2
HY-109137 Selgantolimod Agonist 98.23% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-109104 Telratolimod Agonist 98.98% Phase 1
Pre-clinical Phase
生物活性分子 (38)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128799 CL097 Agonist 99.89% 否
HY-117066 CL075 Agonist 99.25% 否
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% 否
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% 否
HY-103697 Gardiquimod Agonist 99.91% 否
HY-103697A Gardiquimod diTFA Agonist ≥99.0% 否
HY-103698 TLR7/8 agonist 1 Agonist 97.33% 否
HY-112050 CU-CPT-8m Antagonist 99.98% 否
HY-130797 TLR7/8 agonist 3 Agonist 99.96% 否
HY-112667 CU-CPT-9a Antagonist 99.36% 否
HY-101929 CU-CPT17e Agonist 99.00% 否
HY-160229 ssRNA40 sodium Activator 93.25% 否
HY-131945 CU-115 Antagonist 99.55% 否
HY-112051 CU-CPT9b Antagonist 99.03% 否
HY-139017 TLR7/8 agonist 4 Agonist 99.04% 否
HY-10018 Toll-like receptor modulator Modulator 99.36% 否
HY-13740S Resiquimod-d5 Agonist 99.84% 否
HY-128799A CL097 hydrochloride Agonist 99.90% 否
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% 否
HY-153543 TLR7/8 agonist 8 Agonist 98.69% 否
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% 否
HY-159102 PVP-037.2 Agonist / 否
HY-138139A AXC-715 hydrochloride Agonist 99.46% 否
HY-141454 TLR8 agonist 2 Agonist / 否
HY-139017A TLR7/8 agonist 4 TFA Agonist / 否
HY-141454A TLR8 agonist 2 hydrochloride Agonist / 否
HY-158694 TLR7 agonist 20 Agonist / 否
HY-121496 3M-011 Agonist / 否
HY-160228 ORN 02 Activator / 否
HY-162845 TLR7/8 agonist 11 Agonist / 否
HY-161630 TLR8 agonist 8 Agonist / 否
HY-161629 TLR8 agonist 7 Agonist / 否
HY-163670 TLR7 agonist 21 Inhibitor / 否
HY-169057 BI1543673 Inhibitor / 否
HY-161631 TLR8 agonist 9 Agonist / 否
HY-160228A ORN 02 sodium Activator / 否
HY-159919 UM-3006 Agonist / 否
HY-159916 AYK004 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tlr8 NCBI NCBI:51311
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