Ret - ret proto-oncogene Gene

中文名称：ret 原癌基因

种属: Mus musculus

同用名: PTC; RET9; RET51; c-Ret

关于 Ret

功能概要

该基因编码的蛋白可启动跨膜受体蛋白酪氨酸激酶活性。涉及多个过程，包括 Peyer 斑块形态发生；神经元细胞间粘附；和后肾肾小球发育的正调节。作用于多个过程的上游或内部，包括动物器官发育；神经系统发育；和大分子代谢过程的正向调控。预计位于多个细胞成分中，包括核内体；膜筏；和神经细胞体。预计是质膜蛋白复合物和受体复合物的一部分。预计在轴突中活跃。预计是质膜的组成部分。以多种结构表达，包括鳃弓；泌尿生殖系统；直觉;神经系统;和感觉器官。用于研究先天性巨结肠；马蹄内翻足;多发性内分泌肿瘤 2B 型；和嗜铬细胞瘤。该基因的人类直系同源物与先天性巨结肠有关；家族性甲状腺髓样癌；多发性内分泌肿瘤 2A 型；多发性内分泌肿瘤 2B 型；和嗜铬细胞瘤。与人类 RET（ret 原癌基因）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including endosome; membrane raft; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (RET proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]