2. Gene
  3. Cgas - cyclic GMP-AMP synthase Gene

Cgas - cyclic GMP-AMP synthase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：环状 GMP-AMP 合酶

种属: Mus musculus

同用名: Mb21d1; E330016A19Rik

基因 ID: 214763 | 基因类型: protein coding

关于 Cgas

Chromosome 9: 78,337,808-78,350,519 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 185 orthologues, 9 paralogues and is associated with 23 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.2), liver E18 (RPKM .8) and 27 other tissues.

功能概要

由该基因编码的蛋白质是一种 DNA 结合胞质蛋白，在检测到细胞质中存在 DNA 后，它会催化环磷酸鸟苷-磷酸腺苷 (cGAMP) 的合成。 cGAMP 结合另一种蛋白质，干扰素基因刺激物 (STING)，导致干扰素的诱导和宿主免疫反应。在存在某些病毒感染的情况下，该基因的表达减少会抑制干扰素的诱导。可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 7 月]

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Cgas 基因产物(1)

mRNA Protein Name
NM_173386.5 NP_775562.2 cyclic GMP-AMP synthase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 2',3'-cyclic GMP-AMP synthase activity IDA
IDA: 通过直接分析推断
24077100 MGI
enables 2',3'-cyclic GMP-AMP synthase activity IMP
IMP: 通过突变表型推断
23258413 MGI
enables DNA binding IDA
IDA: 通过直接分析推断
26829768 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
28759028 MGI
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
24077100 MGI
enables nucleosome binding IDA
IDA: 通过直接分析推断
32911480 MGI
enables poly-ADP-D-ribose modification-dependent protein binding IDA
IDA: 通过直接分析推断
35210392 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
26829768 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
29426904 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
23929945 MGI
involved in activation of innate immune response IMP
IMP: 通过突变表型推断
23258413 MGI
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
24077100 MGI
involved in cAMP-mediated signaling IMP
IMP: 通过突变表型推断
23258413 MGI
involved in cGMP-mediated signaling IDA
IDA: 通过直接分析推断
24077100 MGI
involved in cGMP-mediated signaling IMP
IMP: 通过突变表型推断
23258413 MGI
involved in cellular response to exogenous dsRNA IDA
IDA: 通过直接分析推断
24077100 MGI
involved in cellular response to exogenous dsRNA IMP
IMP: 通过突变表型推断
23258413 MGI
involved in defense response to virus IDA
IDA: 通过直接分析推断
23929945 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: 通过遗传相互作用推断
26371324 MGI
involved in negative regulation of DNA repair IDA
IDA: 通过直接分析推断
35210392 MGI
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
31544964 MGI
involved in negative regulation of double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
30356214 MGI
involved in paracrine signaling IDA
IDA: 通过直接分析推断
24077100 MGI
involved in positive regulation of cellular senescence IDA
IDA: 通过直接分析推断
28759028 MGI
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
23929945 MGI
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
23258413 MGI
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
24077100 MGI
acts upstream of or within regulation of T cell activation IGI
IGI: 通过遗传相互作用推断
26371324 MGI
acts upstream of or within regulation of immune response IGI
IGI: 通过遗传相互作用推断
26371324 MGI
acts upstream of or within regulation of immunoglobulin production IGI
IGI: 通过遗传相互作用推断
26371324 MGI
acts upstream of or within regulation of type I interferon production IGI
IGI: 通过遗传相互作用推断
26371324 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
23258413 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
35210392 MGI
located in nucleus IDA
IDA: 通过直接分析推断
31544964 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
30827685 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cgas 蛋白结构

PHA03247

PHA03247: cl33720 (2 - 141)

Mab-21

Mab-21: pfam03281 (199 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 507 a.a.
蛋白主名 其他名称

cyclic GMP-AMP synthase

2'3'-cGAMP synthase

Mab-21 domain containing 1

cGAMP synthase

mab-21 domain-containing protein 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-160406 SNX281 Agonist 99.08% Phase 1
Pre-clinical Phase
生物活性分子 (46)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114180 RU.521 Inhibitor 99.89% 否
HY-131454 SR-717 Agonist 99.89% 否
HY-133916 G140 Inhibitor 98.11% 否
HY-128583 G150 Inhibitor 99.12% 否
HY-150751 ODN TTAGGG Antagonist 99.87% 否
HY-114182 PF-06928215 Inhibitor 99.69% 否
HY-139056 SU0268 Inhibitor 99.96% 否
HY-W021040 Fludioxonil 99.94% 否
HY-123230 Trifloxystrobin Inhibitor 99.49% 否
HY-114181 IRAK4-IN-4 Inhibitor 99.85% 否
HY-149526 cGAS-IN-1 Inhibitor 98.29% 否
HY-150751C ODN TTAGGG sodium Antagonist 99.87% 否
HY-160546 cGAS-IN-2 Inhibitor 99.67% 否
HY-B1331 Cyromazine 99.79% 否
HY-138646 Poly(deoxyadenylic-thymidylic) acid sodium Activator / 否
HY-158045 PROTAC PARP1 degrader-1 Inhibitor / 否
HY-164288 TDI-6570 Inhibitor 99.64% 否
HY-131454A SR-717 free acid Agonist / 否
HY-118578 Furalaxyl Inhibitor / 否
HY-123230R Trifloxystrobin (Standard) Inhibitor / 否
HY-123230S Trifloxystrobin-d6 Inhibitor / 否
HY-13735H Quinacrine acetate / 否
HY-144328 STING agonist-10 Activator / 否
HY-144329 STING agonist-11 Activator / 否
HY-150751A Biotin-labeled ODN TTAGGG sodium / 否
HY-150751B FITC-labeled ODN TTAGGG sodium Antagonist / 否
HY-158126 G-quadruplex ligand 2 Inhibitor / 否
HY-162133 MSA-2-Pt Agonist / 否
HY-162459 cGAS-IN-3 Inhibitor / 否
HY-162944 NA-Ir / 否
HY-162966 MS7829 / 否
HY-162967 MS8588 / 否
HY-163461 4F-DDC Inhibitor / 否
HY-B0621S1 Triclabendazole-13C,d3 Inhibitor / 否
HY-N12507 Eupenicisirenin C Inhibitor / 否
HY-P3041 Chromostatin (bovine) Inhibitor / 否
HY-RS02575 CGA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02576 CGAS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02577 Cgas Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02578 Cgas Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-114730 CGA-JK3 Inhibitor / 否
HY-12464 Butafenacil / 否
HY-132221 CU-32 Inhibitor / 否
HY-79128S1 Fmoc-L-Lys (Boc)-OH-13C6,15N2 Inhibitor / 否
HY-79648S Fmoc-Methylalanine-d3 / 否
HY-W020788 Benoxacor Agonist 99.39% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cgas NCBI NCBI:115004
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z