RYBP - RING1 and YY1 binding protein Gene

中文名称：RING1 和 YY1 结合蛋白

种属: Homo sapiens

同用名: AAP1; DEDAF; YEAF1; APAP-1

基因 ID: 23429 | 基因类型: protein coding

关于 RYBP

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,374,593-72,446,623 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 232 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 20.7), testis (RPKM 18.4) and 25 other tissues.

功能概要

预测可实现 DNA 结合活性和转录共调节因子活性。参与多个过程，包括组蛋白 H2A 单泛素化；蛋白酶体泛素依赖性蛋白质分解代谢过程的负调节；和转录的正调控，DNA 模板。位于核质中。与 PcG 蛋白复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity and transcription coregulator activity. Involved in several processes, including histone H2A monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. Colocalizes with PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

RYBP 基因产物(1)

mRNA	Protein	Name
NM_012234.6	NP_036366.3	RING1 and YY1-binding protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nucleic acid binding	EXP EXP: 通过实验结果推断	19170609	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chromatin remodeling	IDA IDA: 通过直接分析推断	16943429	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	27060496	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	27060496	GOA
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	27060496	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PcG protein complex	IDA IDA: 通过直接分析推断	16943429	GOA
located in nucleus	IDA IDA: 通过直接分析推断	27060496	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RYBP 蛋白结构

zf-RanBP

0
100
200
317 a.a.

蛋白主名

其他名称

RING1 and YY1-binding protein

DED-associated factor

RYBP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RYBP	Q8N488	NF2	Homo sapiens	P35240-4	Validated Y2H	32814053
种属内	RYBP	Q8N488	NF2	Homo sapiens	P35240-4	Y2H Pooling	32814053
种属内	RYBP	Q8N488	NF2	Homo sapiens	P35240-4	Y2H Array	32814053
种属内	RYBP	Q8N488	COMT	Homo sapiens	P21964-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	COMT	Homo sapiens	P21964-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	COMT	Homo sapiens	P21964-2	Y2H Array	32814053
种属内	RYBP	Q8N488	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
种属内	RYBP	Q8N488	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
种属内	RYBP	Q8N488	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
种属内	RYBP	Q8N488	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
种属内	RYBP	Q8N488	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
种属内	RYBP	Q8N488	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
种属内	RYBP	Q8N488	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	RYBP	Q8N488	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	RYBP	Q8N488	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	RYBP	Q8N488	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	RYBP	Q8N488	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
种属内	RYBP	Q8N488	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
种属内	RYBP	Q8N488	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
种属内	RYBP	Q8N488	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
种属内	RYBP	Q8N488	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
种属内	RYBP	Q8N488	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
种属内	RYBP	Q8N488	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	XAGE1A	Homo sapiens	Q9HD64	Validated Y2H	32296183
种属间	RYBP	Q8N488	P0C6X7-PRO_0000037319	Human SARS coronavirus	P0C6X7-PRO_0000037319	Lumier	22046132
种属间	RYBP	Q8N488	P0C6X7-PRO_0000037319	Human SARS coronavirus	P0C6X7-PRO_0000037319	Y2H Pooling	22046132
种属内	RYBP	Q8N488	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
种属内	RYBP	Q8N488	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
种属内	RYBP	Q8N488	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
种属内	RYBP	Q8N488	TGM2	Homo sapiens	P21980-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	TGM2	Homo sapiens	P21980-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	TGM2	Homo sapiens	P21980-2	Y2H Array	32814053
种属内	RYBP	Q8N488	F8	Homo sapiens	P00451-2	Y2H Array	32814053
种属内	RYBP	Q8N488	F8	Homo sapiens	P00451-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	F8	Homo sapiens	P00451-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	q9p1n4_human	Homo sapiens	Q9P1N4	Y2H Array	32814053
种属内	RYBP	Q8N488	q9p1n4_human	Homo sapiens	Q9P1N4	Y2H Pooling	32814053
种属内	RYBP	Q8N488	q9p1n4_human	Homo sapiens	Q9P1N4	Validated Y2H	32814053
种属内	RYBP	Q8N488	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
种属内	RYBP	Q8N488	TDP1	Homo sapiens	Q9NUW8	Y2H Array	32814053
种属内	RYBP	Q8N488	TDP1	Homo sapiens	Q9NUW8	Y2H Pooling	32814053
种属内	RYBP	Q8N488	TDP1	Homo sapiens	Q9NUW8	Validated Y2H	32814053
种属内	RYBP	Q8N488	UBC	Homo sapiens	P0CG48	Pull Down	17070805
种属内	RYBP	Q8N488	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	17070805
种属内	RYBP	Q8N488	SRP9	Homo sapiens	P49458	Y2H Pooling	32814053
种属内	RYBP	Q8N488	SRP9	Homo sapiens	P49458	Validated Y2H	32814053
种属内	RYBP	Q8N488	SRP9	Homo sapiens	P49458	Y2H Array	32814053
种属内	RYBP	Q8N488	PKM	Homo sapiens	P14618	Validated Y2H	32814053
种属内	RYBP	Q8N488	PKM	Homo sapiens	P14618	Y2H Array	32814053
种属内	RYBP	Q8N488	PKM	Homo sapiens	P14618	Y2H Pooling	32814053
种属内	RYBP	Q8N488	TP53	Homo sapiens	P04637	Anti Bait CoIP	34316702
种属内	RYBP	Q8N488	TP53	Homo sapiens	P04637	Anti Tag CoIP	19098711
种属内	RYBP	Q8N488	TP53	Homo sapiens	P04637	Anti Bait CoIP	19098711
种属内	RYBP	Q8N488	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	19098711
种属内	RYBP	Q8N488	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	19098711
种属内	RYBP	Q8N488	MDM2	Homo sapiens	Q00987	Pull Down	19098711
种属内	RYBP	Q8N488	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	RYBP	Q8N488	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	RYBP	Q8N488	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	RYBP	Q8N488	FUS	Homo sapiens	P35637	Anti Bait CoIP	34316702
种属内	RYBP	Q8N488	NEFL	Homo sapiens	P07196	Y2H Array	32814053
种属内	RYBP	Q8N488	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
种属内	RYBP	Q8N488	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
种属内	RYBP	Q8N488	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	RYBP	Q8N488	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	RYBP	Q8N488	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	RYBP	Q8N488	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	RYBP	Q8N488	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	RYBP	Q8N488	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587-2	Imaging	17070805
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587-2	Anti Tag CoIP	28514442
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587-2	Anti Tag CoIP	17070805
种属内	RYBP	Q8N488	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
种属内	RYBP	Q8N488	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
种属内	RYBP	Q8N488	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Anti Bait CoIP	34316702
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	TAP	27705803
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	28514442
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Y2H Prey Pooling	32296183
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Validated Y2H	32296183
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Y2H Array	32296183
种属内	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	TAP	24981860
种属内	RYBP	Q8N488	SNCB	Homo sapiens	Q16143	Validated Y2H	32814053
种属内	RYBP	Q8N488	SNCB	Homo sapiens	Q16143	Y2H Array	32814053
种属内	RYBP	Q8N488	SNCB	Homo sapiens	Q16143	Y2H Pooling	32814053
种属内	RYBP	Q8N488	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
种属内	RYBP	Q8N488	GFAP	Homo sapiens	P14136	Y2H Array	32814053
种属内	RYBP	Q8N488	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
种属内	RYBP	Q8N488	GRN	Homo sapiens	P28799	Validated Y2H	32814053
种属内	RYBP	Q8N488	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
种属内	RYBP	Q8N488	GRN	Homo sapiens	P28799	Y2H Array	32814053
种属内	RYBP	Q8N488	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
种属内	RYBP	Q8N488	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
种属内	RYBP	Q8N488	DR1	Homo sapiens	Q01658	Y2H Array	32814053
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Array	25416956
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Array	32296183
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	TAP	27705803
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Pooling	16189514
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Anti Bait CoIP	34316702
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Pull Down	16943429
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Prey Pooling	25416956
种属内	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Prey Pooling	32296183
种属内	RYBP	Q8N488	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
种属间	RYBP	Q8N488	Trpm7	Mus musculus	Q923J1	Anti Tag CoIP	24855944
种属间	RYBP	Q8N488	Trpm7	Mus musculus	Q923J1	IF	24855944
种属内	RYBP	Q8N488	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
种属内	RYBP	Q8N488	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
种属内	RYBP	Q8N488	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
种属内	RYBP	Q8N488	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
种属内	RYBP	Q8N488	PEX1	Homo sapiens	O43933	Y2H Array	32814053
种属内	RYBP	Q8N488	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 RYBP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74590	RYBP Protein, Human (sf9, His-GST)	Q8N488 (M1-F228)	≥95%

RYBP 抗体

目录号	产品名	应用	反应物种
HY-P82052	RYBP Antibody (YA1797)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Pontocerebellar Hypoplasia, Type 13

PCH13	Pontocerebellar Hypoplasia Type 13
Pontocerebellar Hypoplasia 13	Doid:0112332
Hypoplasia, Pontocerebellar, Type 13

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12366	RYBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RYBP	MGD	MGI:1929059
Rattus norvegicus	RYBP	RGD	RGD:1307077
Bos taurus	RYBP	VGNC	VGNC:106910
Macaca mulatta	RYBP	VGNC	VGNC:84088
Canis familiaris	RYBP	VGNC	VGNC:58331
Felis catus	RYBP	VGNC	VGNC:102696
Others	RYBP	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4