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  3. RYBP - RING1 and YY1 binding protein Gene

RYBP - RING1 and YY1 binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RING1 和 YY1 结合蛋白

种属: Homo sapiens

同用名: AAP1; DEDAF; YEAF1; APAP-1

基因 ID: 23429 | 基因类型: protein coding

关于 RYBP

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,374,593-72,446,623 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 232 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 20.7), testis (RPKM 18.4) and 25 other tissues.

功能概要

预测可实现 DNA 结合活性和转录共调节因子活性。参与多个过程，包括组蛋白 H2A 单泛素化；蛋白酶体泛素依赖性蛋白质分解代谢过程的负调节；和转录的正调控，DNA 模板。位于核质中。与 PcG 蛋白复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity and transcription coregulator activity. Involved in several processes, including histone H2A monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. Colocalizes with PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

RYBP 基因产物(1)

mRNA Protein Name
NM_012234.6 NP_036366.3 RING1 and YY1-binding protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nucleic acid binding EXP
EXP: 通过实验结果推断
19170609 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
16943429 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
27060496 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
27060496 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
27060496 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of PcG protein complex IDA
IDA: 通过直接分析推断
16943429 GOA
located in nucleus IDA
IDA: 通过直接分析推断
27060496 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RYBP 蛋白结构

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (111 - 134)

  • 0
  • 100
  • 200
  • 317 a.a.
蛋白主名 其他名称

RING1 and YY1-binding protein

DED-associated factor

重组 RYBP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74590 RYBP Protein, Human (sf9, His-GST) Q8N488 (M1-F228) ≥95%

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 13

PCH13

Pontocerebellar Hypoplasia Type 13

Pontocerebellar Hypoplasia 13

Doid:0112332

Hypoplasia, Pontocerebellar, Type 13
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12366 RYBP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RYBP MGD MGI:1929059
Rattus norvegicus RYBP RGD RGD:1307077
Bos taurus RYBP VGNC VGNC:106910
Macaca mulatta RYBP VGNC VGNC:84088
Canis familiaris RYBP VGNC VGNC:58331
Felis catus RYBP VGNC VGNC:102696
Others RYBP NCBI
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