BRD1 - bromodomain containing 1 Gene

中文名称：含溴结构域 1

种属: Homo sapiens

同用名: BRL; BRPF1; BRPF2

基因 ID: 23774 | 基因类型: protein coding

关于 BRD1

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,773,278-49,827,873 (from NCBI)

This gene has 8 transcripts (splice variants), 277 orthologues and 8 paralogues. Broad expression in testis (RPKM 11.6), bone marrow (RPKM 4.4) and 25 other tissues.

功能概要

该基因编码一种含溴结构域的蛋白质，该蛋白质定位于细胞核并可与 DNA 和组蛋白尾部相互作用。编码的蛋白质是 MOZ/MORF 乙酰转移酶复合物的组成部分，可以刺激组蛋白 H3 和 H4 的乙酰化，从而可能在基因激活中发挥作用。在某些研究人群中，该基因的变异与精神分裂症和双相情感障碍有关。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 3 月]

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

BRD1 基因产物(10)

mRNA	Protein	Name
NM_001304808.3	NP_001291737.1	bromodomain-containing protein 1 isoform 1
NM_001304809.1	NP_001291738.1	bromodomain-containing protein 1 isoform 2
NM_001349940.2	NP_001336869.1	bromodomain-containing protein 1 isoform 3
NM_001349941.2	NP_001336870.1	bromodomain-containing protein 1 isoform 4
NM_001349942.2	NP_001336871.1	bromodomain-containing protein 1 isoform 5
NM_001394548.1	NP_001381477.1	bromodomain-containing protein 1 isoform 6
NM_001394549.1	NP_001381478.1	bromodomain-containing protein 1 isoform 7
NM_001394550.1	NP_001381479.1	bromodomain-containing protein 1 isoform 8
NM_001394551.1	NP_001381480.1	bromodomain-containing protein 1 isoform 2
NM_001394552.1	NP_001381481.1	bromodomain-containing protein 1 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to histone H3K14 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: 通过直接分析推断	16387653	GOA
enables histone binding	IDA IDA: 通过直接分析推断	21880731	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	27142060	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: 通过直接分析推断	16387653	GOA
part of histone H3-K14 acetyltransferase complex	IDA IDA: 通过直接分析推断	21753189	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10602503	GOA
located in nucleus	IMP IMP: 通过突变表型推断	21753189	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRD1 蛋白结构

EPL1

PHD_2

zf-HC5HC2H_2

Bromodomain

PWWP

0
200
400
600
800
1000
1058 a.a.

蛋白主名

其他名称

bromodomain-containing protein 1

BR140-like protein

关联疾病

疾病名称

别名

Herpes Zoster Oticus

Nervus Intermedius Neuralgia	Ramsay Hunt Syndrome Type 2
Geniculate Herpes Zoster	Geniculate Neuralgia
Herpes Zoster Auricularis	Herpetic Geniculate Ganglionitis
Ramsay Hunt Syndrome Type Ii	Ramsey Hunt Syndrome
Facial Nerve Palsy Due To Vzv	Facial Nerve Palsy Due To Herpes Zoster Infection
Facial Nerve Paralysis Due To Vzv	Hunt Syndrome
Hunt'S Syndrome	Ramsay Hunt Syndrome
Myoclonus And Ataxia

Nodular Prostate

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Adult Brain Stem Glioma

Adult Brainstem Neuroglial Tumor

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19537	NI-57	Inhibitor	99.96%	否
HY-18665	GSK-5959	Inhibitor	98.74%	否
HY-13959	MS436	Inhibitor	99.13%	否
HY-111875	SNIPER(BRD)-1	Inhibitor	99.43%	否
HY-RS01596	BRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-100670	Olinone	Inhibitor	/	否
HY-122626	BRPF1B/TRIM24-IN-1	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	BRD1	VGNC	VGNC:26556
Canis familiaris	BRD1	VGNC	VGNC:38518
Macaca mulatta	BRD1	VGNC	VGNC:70280
Mus musculus	BRD1	MGD	MGI:1924161
Rattus norvegicus	BRD1	RGD	RGD:1311855

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BRD1 - bromodomain containing 1 Gene

关于 BRD1

功能概要

BRD1 基因产物(10)

BRD1 蛋白结构

关联疾病

直系同源

热门区域

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BRD1 - bromodomain containing 1 Gene

关于 BRD1

功能概要

BRD1 基因产物(10)

BRD1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z