2. Gene
  3. Ptpn1 - protein tyrosine phosphatase, non-receptor type 1 Gene

Ptpn1 - protein tyrosine phosphatase, non-receptor type 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Ptp

基因 ID: 24697 | 基因类型: protein coding

关于 Ptpn1

功能概要

Enables Insulin Receptor binding activity; protein Phosphatase 2A binding activity; and protein tyrosine Phosphatase activity. Involved in protein dephosphorylation and regulation of Insulin Receptor signaling pathway. Located in cytoplasmic vesicle; cytosol; and mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine Phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn1 基因产物(1)

mRNA Protein Name
NM_012637.2 NP_036769.1 tyrosine-protein phosphatase non-receptor type 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables insulin receptor binding IDA
IDA: 通过直接分析推断
7711057 RGD
enables insulin receptor binding IMP
IMP: 通过突变表型推断
12850498 RGD
enables phosphatase activity IDA
IDA: 通过直接分析推断
10409197 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
7685104 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
17897622 RGD
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
7711057 RGD
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
17563729 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
18278556 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
31502193 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
15271661 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
18278556 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
18456732 RGD
involved in cellular response to nerve growth factor stimulus IMP
IMP: 通过突变表型推断
18796006 RGD
involved in cellular response to nitric oxide IMP
IMP: 通过突变表型推断
12117721 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
15271661 RGD
involved in dephosphorylation IDA
IDA: 通过直接分析推断
10409197 RGD
involved in dephosphorylation IMP
IMP: 通过突变表型推断
10409197 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16373608 RGD
involved in negative regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
10484424 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
18796006 RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
12117721 RGD
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
31502193 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
18278556 RGD
involved in negative regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
10409197 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
18278556 RGD
involved in positive regulation of endothelial cell apoptotic process IMP
IMP: 通过突变表型推断
31502193 RGD
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
22569287 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
22569287 RGD
involved in protein dephosphorylation IDA
IDA: 通过直接分析推断
7711057 RGD
involved in protein dephosphorylation IMP
IMP: 通过突变表型推断
17563729 RGD
involved in regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
12941932 RGD
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
22844492 RGD
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
22844492 RGD
involved in regulation of proteolysis IMP
IMP: 通过突变表型推断
18278556 RGD
involved in response to angiotensin IEP
IEP: 通过表达模式推断
22526299 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
21788123 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22844492 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22844492 RGD
located in mitochondrial crista IDA
IDA: 通过直接分析推断
18583343 RGD
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
18583343 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
22844492 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 1

PTP-1B

protein-tyrosine phosphatase 1B

Ptpn1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Ptpn1 P20417 EGFR Homo sapiens P00533
Phosphatase Assay
8621392
种属间
Ptpn1 P20417 EGFR Homo sapiens P00533
Photoaffinity Labelling
8621392
种属间
Ptpn1 P20417 EGFR Homo sapiens P00533
Pull Down
7693694
种属间
Ptpn1 P20417 EGFR Homo sapiens P00533
Phosphatase Assay
7685104
种属间
Ptpn1 P20417 EGFR Homo sapiens P00533
Competition Binding
7693694
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145923 Osunprotafib Inhibitor 99.43% 否
HY-153446 Tegeprotafib Inhibitor 98.12% 否
HY-156606 Anticancer agent 142 Inhibitor / 否
HY-RS11415 PTPN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptpn1 NCBI NCBI:5770
Mus musculus Ptpn1 NCBI NCBI:19246
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z