Arrb2 - arrestin, beta 2 Gene

种属: Rattus norvegicus

同用名: BARRES

基因 ID: 25388 | 基因类型: protein coding

关于 Arrb2

功能概要

Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and Arrestin family protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of apoptotic process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Biomarker of hypertension; portal hypertension; and type 2 diabetes mellitus. Orthologous to human ARRB2 (Arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Arrb2 基因产物(1)

mRNA	Protein	Name
NM_012911.2	NP_037043.1	beta-arrestin-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 14-3-3 protein binding	IDA IDA: 通过直接分析推断	19008961	RGD
enables D1 dopamine receptor binding	IPI IPI: 通过物理相互作用推断	19200235	RGD
enables alpha-1A adrenergic receptor binding	IPI IPI: 通过物理相互作用推断	18523139	RGD
enables alpha-1B adrenergic receptor binding	IDA IDA: 通过直接分析推断	18523139	RGD
enables arrestin family protein binding	IPI IPI: 通过物理相互作用推断	23886940	RGD
enables follicle-stimulating hormone receptor binding	IPI IPI: 通过物理相互作用推断	16899567	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17984062	RGD
enables mitogen-activated protein kinase binding	IPI IPI: 通过物理相互作用推断	19200235	RGD
enables platelet activating factor receptor binding	IPI IPI: 通过物理相互作用推断	23911909	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	15361545	RGD
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	12890920	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	15498833	RGD
enables type 1 angiotensin receptor binding	IPI IPI: 通过物理相互作用推断	19522833	RGD
NOT enables type 2A serotonin receptor binding	IPI IPI: 通过物理相互作用推断	19919577	RGD
enables type 2A serotonin receptor binding	IPI IPI: 通过物理相互作用推断	19919577	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	157224	RGD
involved in circadian rhythm	IEP IEP: 通过表达模式推断	34919270	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: 通过突变表型推断	21926413	RGD
involved in endocytosis	IDA IDA: 通过直接分析推断	12600992	RGD
involved in follicle-stimulating hormone signaling pathway	IDA IDA: 通过直接分析推断	16899567	RGD
involved in negative regulation of GTPase activity	IDA IDA: 通过直接分析推断	1517224	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	19171933	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	26621121	RGD
involved in negative regulation of opioid receptor signaling pathway	IDA IDA: 通过直接分析推断	34919270	RGD
involved in negative regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	20650893	RGD
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: 通过突变表型推断	19171933	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: 通过突变表型推断	19171933	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: 通过突变表型推断	19254952	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	19014370	RGD
involved in positive regulation of calcium ion transport	IMP IMP: 通过突变表型推断	21078978	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: 通过突变表型推断	28274926	RGD
involved in positive regulation of epithelial cell apoptotic process	IMP IMP: 通过突变表型推断	24719556	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: 通过突变表型推断	19014370	RGD
involved in positive regulation of opioid receptor signaling pathway	IMP IMP: 通过突变表型推断	19014370	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: 通过突变表型推断	19171933	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: 通过突变表型推断	19254952	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	19171933	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	19254952	RGD
involved in positive regulation of receptor internalization	IMP IMP: 通过突变表型推断	16120787	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	1517224	RGD
involved in response to morphine	IEP IEP: 通过表达模式推断	12614678	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	16899567	RGD
located in cytoplasm	IDA IDA: 通过直接分析推断	14757828	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	1517224	RGD
located in endosome	IDA IDA: 通过直接分析推断	14757828	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	1517224	RGD
is active in postsynaptic density	IDA IDA: 通过直接分析推断	1517224	RGD
located in postsynaptic membrane	IDA IDA: 通过直接分析推断	157224	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

beta-arrestin-2

Arrb2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Arrb2	P29067	MAP2K4	Homo sapiens	P45985	CoIP	11090355
种属间	Arrb2	P29067	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	17984062
种属内	Arrb2	P29067	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	18191226
种属内	Arrb2	P29067	Mapk10	Rattus norvegicus	P49187	CoIP	11090355
种属内	Arrb2	P29067	FLNA	Homo sapiens	P21333	Anti Tag CoIP	17984062
种属内	Arrb2	P29067	Arrb2	Rattus norvegicus	P29067	FRET	17984062
种属内	Arrb2	P29067	Map3k5	Mus musculus	O35099	CoIP	11090355
种属间	Arrb2	P29067	AKT1	Homo sapiens	P31749	Anti Bait CoIP	18191226
种属间	Arrb2	P29067	LIMK1	Homo sapiens	P53667	Pull Down	17500066
种属内	Arrb2	P29067	Arrb2	Rattus norvegicus	P29067	BRET	17984062
种属内	Arrb2	P29067	Oprm1	Mus musculus	P42866	Anti Tag CoIP	17725581
种属内	Arrb2	P29067	Agtr1	Rattus norvegicus	P25095	BRET	16359671
种属内	Arrb2	P29067	GPR3	Homo sapiens	P46089	Anti Tag CoIP	24069330
种属间	Arrb2	P29067	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	18191226
种属间	Arrb2	P29067	AKT1	Homo sapiens	P31749	Pull Down	18191226
种属内	Arrb2	P29067	Rgs9	Mus musculus	O54828-1	Anti Bait CoIP	17725581
种属内	Arrb2	P29067	Arrb2	Rattus norvegicus	P29067	Anti Tag CoIP	17984062

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01029	ARRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Arrb2	NCBI	NCBI:409

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Arrb2 - arrestin, beta 2 Gene

关于 Arrb2

功能概要

Arrb2 基因产物(1)

Arrb2 蛋白互作信息

直系同源

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Arrb2 - arrestin, beta 2 Gene

关于 Arrb2

功能概要

Arrb2 基因产物(1)

Arrb2 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z