Ptk2 - protein tyrosine kinase 2 Gene

中文名称：蛋白酪氨酸激酶 2

种属: Rattus norvegicus

同用名: FAK; FRNK; p125FAK

关于 Ptk2

功能概要

该基因编码的蛋白可启动多种功能，包括相同的蛋白质结合活性；整合素结合活性；和磷脂酰肌醇 3-激酶结合活性。参与多个过程，包括细胞氯离子稳态；细胞群增殖的正向调节；和细胞迁移的调节。位于几种细胞成分中，包括基底外侧质膜；粘着斑；和核腔。活跃于谷氨酸能突触和突触后。用于研究肝细胞癌；高血压;和肾炎。高血压的生物标志物；缺血;和尿毒症。该基因的人类直系同源物与平滑肌瘤有关；肺小细胞癌；和肺动脉高压。与人 PTK2（蛋白酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including identical protein binding activity; Integrin binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of cell population proliferation; and regulation of cell migration. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and nuclear lumen. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]