LAT - linker for activation of T cells Gene

中文名称：激活 T 细胞的接头

种属: Homo sapiens

同用名: LAT1; pp36; IMD52

基因 ID: 27040 | 基因类型: protein coding

关于 LAT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,984,803-28,990,784 (from NCBI)

This gene has 16 transcripts (splice variants), 87 orthologues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues.

功能概要

在激活 T 细胞抗原受体 (TCR) 信号转导通路后，由该基因编码的蛋白质被 ZAP-70/Syk 蛋白酪氨酸激酶磷酸化。这种跨膜蛋白定位于脂筏，并作为含 SH2 结构域蛋白的停靠位点。磷酸化后，该蛋白质将多个衔接蛋白和下游信号分子募集到位于 TCR 结合位点附近的多分子信号复合物中。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is phosphorylated by ZAP-70/Syk Protein Tyrosine Kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LAT 基因产物(4)

mRNA	Protein	Name
NM_001014987.2	NP_001014987.1	linker for activation of T-cells family member 1 isoform b
NM_001014988.2	NP_001014988.1	linker for activation of T-cells family member 1 isoform c
NM_001014989.2	NP_001014989.2	linker for activation of T-cells family member 1 isoform d
NM_014387.4	NP_055202.1	linker for activation of T-cells family member 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables molecular condensate scaffold activity	IDA IDA: 通过直接分析推断	33080222	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9489702	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	12186560	GOA
enables signaling receptor complex adaptor activity	IDA IDA: 通过直接分析推断	9489702	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Ras protein signal transduction	IMP IMP: 通过突变表型推断	12646565	GOA
involved in T cell receptor signaling pathway	IDA IDA: 通过直接分析推断	25907557	GOA
involved in calcium-mediated signaling	IMP IMP: 通过突变表型推断	12646565	GOA
involved in immune response	IDA IDA: 通过直接分析推断	15100278	GOA
involved in integrin-mediated signaling pathway	IDA IDA: 通过直接分析推断	15100278	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	12646565	GOA
involved in membrane raft distribution	IDA IDA: 通过直接分析推断	33080222	GOA
involved in positive regulation of protein kinase activity	IEP IEP: 通过表达模式推断	14624253	GOA
involved in regulation of T cell activation	IMP IMP: 通过突变表型推断	12646565	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TCR signalosome	IDA IDA: 通过直接分析推断	33080222	GOA
located in immunological synapse	IDA IDA: 通过直接分析推断	12646565	GOA
located in membrane	IDA IDA: 通过直接分析推断	12646565	GOA
is active in plasma membrane	IDA IDA: 通过直接分析推断	9729044	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LAT 蛋白结构

LAT

0
100
200
262 a.a.

蛋白主名

其他名称

linker for activation of T-cells family member 1

36 kDa phospho-tyrosine adapter protein

LAT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LAT	O43561	LCK	Homo sapiens	P06239	Anti Bait CoIP	16938345
种属内	LAT	O43561	EGFR	Homo sapiens	P00533	Ub Reconstruction	31980649
种属内	LAT	O43561	EGFR	Homo sapiens	P00533	Lumier	24658140
种属内	LAT	O43561	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
种属内	LAT	O43561	SGTA	Homo sapiens	O43765	Y2H Array	25416956
种属内	LAT	O43561	GRB2	Homo sapiens	P62993	Pull Down	10811803
种属内	LAT	O43561	GRB2	Homo sapiens	P62993	CoIP	10811803
种属内	LAT	O43561	GRB2	Homo sapiens	P62993	CoIP	9489702
种属内	LAT	O43561	PLCG1	Homo sapiens	P19174	Anti Bait CoIP	16938345
种属内	LAT	O43561	PLCG1	Homo sapiens	P19174	CoIP	10811803
种属内	LAT	O43561	PIK3R1	Homo sapiens	P27986	Pull Down	10811803
种属内	LAT	O43561	PIK3R1	Homo sapiens	P27986	CoIP	10811803
种属内	LAT	O43561	PTPN1	Homo sapiens	P18031	Pull Down	12857726
种属内	LAT	O43561	PTPN1	Homo sapiens	P18031	Phosphatase Assay	12857726

种属间: 跨种属相互作用 种属内: 同种属相互作用

LAT 抗体

目录号	产品名	应用	反应物种
HY-P81297	Phospho-LAT (Tyr191) Antibody (YA1021)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P81297A	Phospho-LAT (Tyr200) Antibody (YA1022)	WB	Human
HY-P83416	LAT Antibody (YA3161)	WB, IHC-P, IP	Human

关联疾病

疾病名称

别名

Immunodeficiency 52

Severe Combined Immunodeficiency Due To Lat Deficiency	IMD52
Scid Due To Lat Deficiency	Immunodeficiency, Type 52

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Lymphopenia

Lymphocytopenia

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-107191	Sildenafil Mesylate	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-16929	Latrunculin A	Inhibitor	≥98.0%	Phase 4

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-138489	TRULI	Modulator	99.98%	否
HY-150042	TDI-011536	Inhibitor	99.91%	否
HY-108540	BCH	Inducer	99.13%	否
HY-147082	GA-017	Activator	98.95%	否
HY-W011391	GPNA hydrochloride		99.91%	否
HY-139330	MGH-CP1	Inducer	99.56%	否
HY-160769	NIBR-LTSi	Activator	99.97%	否
HY-147165	VT02956	Inhibitor	99.58%	否
HY-120139	KMH-233	Inhibitor	98.11%	否
HY-130504	Propargyl-PEG1-acid		≥97.0%	否
HY-N8847	α-Ionone	Activator	94.30%	否
HY-W763582	GelMA, 30% methacrylation		/	否
HY-N3999	Venuloside A		99.82%	否
HY-120139A	(R)-KMH-233		/	否
HY-127042	6,7-Epoxy-latrunculin A	Inhibitor	/	否
HY-129934S	Latanoprost ethyl amide-d4		/	否
HY-158217	GelMA, 30% methacrylation, Green Fluorescent		/	否
HY-158217A	GelMA, 60% methacrylation, Green Fluorescent		/	否
HY-158217B	GelMA, 90% methacrylation, Green Fluorescent		/	否
HY-158218	GelMA, 30% methacrylation, Red Fluorescent		/	否
HY-RS07536	LAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07537	LAT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07538	LATS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS07539	LATS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W763582A	GelMA, 60% methacrylation		/	否
HY-138110	Toladryl	Antagonist	/	否
HY-147165A	VT02956 hydrochloride	Inhibitor	/	否
HY-164401	QBS10072S		/	否
HY-W140401	Dimethyl nonanedioate		/	否
HY-W763582B	GelMA, 90% methacrylation		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	LAT	VGNC	VGNC:42596
Rattus norvegicus	LAT	RGD	RGD:620802
Mus musculus	LAT	MGD	MGI:1342293
Bos taurus	LAT	VGNC	VGNC:50054
Felis catus	LAT	VGNC	VGNC:63199
Macaca fascicularis	LAT	NCBI	NCBI:102143768
Canis lupus familiaris	LAT	NCBI
Susscrofa domestica	LAT	NCBI
Leporidae	LAT	NCBI
Macaca mulatta	LAT	NCBI	NCBI:704656
Others	LAT	NCBI

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