1. Gene
  2. F2 - coagulation factor II Gene

F2 - coagulation factor II Gene

种属: Rattus norvegicus

基因 ID: 29251 | 基因类型: protein coding

关于 F2

功能概要

Predicted to enable several functions, including heparin binding activity; lipopolysaccharide binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to mechanical stimulus; response to thyrotropin-releasing hormone; and response to thyroxine. Located in collagen-containing extracellular matrix and extracellular space. Used to study several diseases, including atherosclerosis; end stage renal disease; hyperhomocysteinemia; obesity; and thrombophilia (multiple). Biomarker of Bacterial pneumonia; brain edema; calcium oxalate nephrolithiasis; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, Thrombin). [provided by Alliance of Genome Resources, Apr 2022]

F2 基因产物(1)

mRNA Protein Name
NM_022924.2 NP_075213.2 prothrombin precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
22915765 RGD
involved in positive regulation of blood coagulation IMP
IMP: 通过突变表型推断
20664909 RGD
involved in response to Thyroglobulin triiodothyronine IEP
IEP: 通过表达模式推断
18336749 RGD
involved in response to inactivity IEP
IEP: 通过表达模式推断
16078333 RGD
involved in response to thyrotropin-releasing hormone IEP
IEP: 通过表达模式推断
18336749 RGD
involved in response to thyroxine IEP
IEP: 通过表达模式推断
18336749 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
21191574 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
16078333 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

prothrombin

coagulation factor 2

thrombin

重组 F2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74241 Coagulation Factor II/F2 Protein, Rat (HEK293, His) P18292/NP_075213.2 (Q25-R617) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens F2 NCBI NCBI:2147
Canis familiaris F2 NCBI NCBI:100856539
Felis catus F2 NCBI NCBI:101090463
Macaca fascicularis F2 NCBI NCBI:102131020
Mus musculus F2 NCBI NCBI:14061
Susscrofa domestica F2 NCBI
Leporidae F2 NCBI
Macaca mulatta F2 NCBI NCBI:712729