2. Gene
  3. F2 - coagulation factor II Gene

F2 - coagulation factor II Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cf2; FII; Cf-2

基因 ID: 14061 | 基因类型: protein coding

关于 F2

功能概要

This gene encodes a vitamin K-dependent glycoprotein coagulation factor that plays an important role in the process of blood coagulation and hemostasis. The encoded protein is an inactive zymogen that undergoes enzymatic cleavage by the coagulation Factor Xa to form an active serine protease that converts soluble fibrinogen to insoluble fibrin clot. Most of the mice lacking the encoded protein die at an embryonic stage due to defects in yolk sac vasculature, while the rare nenonates succumb to hemorrhage on the first postnatal day. [provided by RefSeq, Apr 2015]

F2 基因产物(1)

mRNA Protein Name
NM_010168.3 NP_034298.1 prothrombin preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IMP
IMP: 通过突变表型推断
26742564 MGI
enables peptidase activity IMP
IMP: 通过突变表型推断
18305483 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7608171 MGI
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
18398001 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
26742564 MGI
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
26742564 MGI
involved in ligand-gated ion channel signaling pathway IDA
IDA: 通过直接分析推断
26742564 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: 通过突变表型推断
26742564 MGI
acts upstream of or within platelet activation IDA
IDA: 通过直接分析推断
17380206 MGI
acts upstream of or within positive regulation of cell growth IGI
IGI: 通过遗传相互作用推断
18398001 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
18398001 MGI
involved in positive regulation of insulin secretion IDA
IDA: 通过直接分析推断
26742564 MGI
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
26742564 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
18398001 MGI
acts upstream of or within regulation of cell shape IGI
IGI: 通过遗传相互作用推断
18398001 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
16720835 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prothrombin

thrombin

重组 F2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72944 Coagulation Factor II/F2 Protein, Mouse (HEK293, His) Q3TJ94 (Q25-G618) ≥95%

F2 抗体

目录号 产品名 应用 反应物种
HY-P82008 Prothrombin Antibody (YA1753) WB, IHC-P Mouse, Rat

相关产品

Approval
生物活性分子 (11)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12956 Dinoprost 99.63% 否
HY-B0577 Latanoprost Agonist 99.85% 否
HY-19518 Latanoprostene bunod Control 99.85% 否
HY-12956A Dinoprost tromethamine salt ≥98.0% 否
HY-113756A Latanoprost acid Inhibitor 99.62% 否
HY-A0195 Carboprost tromethamine 99.85% 否
HY-128428 Carboprost 99.83% 否
HY-116733 Tafluprost ethyl ester Agonist / 否
HY-B0577R Latanoprost (Standard) Agonist / 否
HY-124219 17-Phenoxy trinor prostaglandin F2α ethyl amide Agonist / 否
HY-158571 17-Phenoxy trinor prostaglandin F2α / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-106037 PGF2α-isopropyl ester / Phase 3
HY-112284 Ebopiprant Antagonist 98.65% Phase 2
HY-17644 Redaporfin 99.44% Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99712 Lonigutamab Inhibitor 95.00% Phase 2
Pre-clinical Phase
生物活性分子 (170)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18777 KC7F2 Inhibitor 99.36% 否
HY-103447 Zearalenone Activator 98.50% 否
HY-112904 XRK3F2 Inhibitor 99.04% 否
HY-15480 NSC 42834 Inhibitor 98.01% 否
HY-147058 SW2_152F Inhibitor 99.77% 否
HY-125848 Ginsenoside F2 Inducer 99.95% 否
HY-Y0110 2-Naphthol 99.91% 否
HY-107381 (+)-Cloprostenol Agonist 99.28% 否
HY-151810 TP0472993 Inhibitor 98.69% 否
HY-156190A NR2F2-IN-1 free base Inhibitor 99.34% 否
HY-103447R Zearalenone (Standard) Activator 98.85% 否
HY-149894 MC-1-F2 99.78% 否
HY-103462 TC-F2 Inhibitor 99.75% 否
HY-154992 2,4-Difluorophenylethynylcobalamin 99.73% 否
HY-113209 8-Isoprostaglandin F2α ≥99.0% 否
HY-113246 15-keto-Prostaglandin F2a 99.2% 否
HY-151809 CYP4A11/CYP4F2-IN-1 Inhibitor 99.82% 否
HY-E70133 Endo-β-N-acetylglucosaminidase F2 / 否
HY-144881 (S)-HH2853 Inhibitor / 否
HY-103447S1 Zearalenone-13C18 98.7% 否
HY-111478 Tiaprost ≥98.0% 否
HY-113209S 8-Iso-PGF2a-d4 / 否
HY-118388 AS604872 Antagonist / 否
HY-12956S Dinoprost-d4 ≥99.0% 否
HY-132277S 15-Keto Bimatoprost-d5 96.65% 否
HY-144882 (R)-HH2853 Inhibitor / 否
HY-156190 NR2F2-IN-1 Inhibitor / 否
HY-B0577S Latanoprost-d4 Agonist ≥98.0% 否
HY-RS04631 F2R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-113208 13,14-Dihydro-15-keto Prostaglandin F2α ≥99.0% 否
HY-D1242 CI Vat green 1 / 否
HY-100571 Cloprostenol isopropyl ester Agonist / 否
HY-106916 Unoprostone Activator ≥99.0% 否
HY-113208A 11β-13,14-Dihydro-15-keto Prostaglandin F2α / 否
HY-113208AS1 11β-13,14-Dihydro-15-keto Prostaglandin F2α-d4 / 否
HY-113209A ent-8-Iso-15(S)-prostaglandin F2α / 否
HY-113209S1 8-iso Prostaglandin F2α-d9 / 否
HY-113459S1 13,14-Dihydro-15-keto Prostaglandin F2α-d4 / 否
HY-113778 15-keto-17-phenyl trinor Prostaglandin F2α / 否
HY-113909 Dinoprost (methoxyamine) / 否
HY-114687 5,7-Dihydroxy-11-ketotetranorprostanoic acid / 否
HY-114695S Prostaglandin F2α-1-glyceryl ester-d5 / 否
HY-114761 Prostaglandin F2α dimethyl amine Antagonist / 否
HY-114810 Prostaglandin F2α serinol amide Agonist / 否
HY-114850 5-trans Prostaglandin F2β / 否
HY-114850A (5R)-Dinoprost tromethamine / 否
HY-116051 16,16-Dimethylprostaglandin F2α / 否
HY-116051A 16,16-Dimethylprostaglandin F2β / 否
HY-116161 Bimatoprost isopropyl ester / 否
HY-116549 Prostaglandin F2α alcohol Agonist / 否
HY-116591 8-Iso-15-keto prostaglandin F2β / 否
HY-116704 11-Deoxyprostaglandin F2α Modulator / 否
HY-117061 Prostaglandin F2α alcohol methyl ether Agonist / 否
HY-118190 AL 8810 methyl ester Agonist / 否
HY-118294 15-OH Tafluprost Control / 否
HY-118599 Prostaglandin F2α ethyl amide / 否
HY-118648 Prostaglandin F2α methyl ester / 否
HY-118816 11β-Prostaglandin F2α / 否
HY-120197 17-Phenyl trinor prostaglandin F2α methyl amide Inhibitor / 否
HY-120955 (+)-5-trans Cloprostenol Control / 否
HY-121314 Cloprostenol / 否
HY-125150 AL-3138 Antagonist / 否
HY-125396 11-Deoxyprostaglandin F2β / 否
HY-125626 8-iso-15-keto Prostaglandin F2α Agonist / 否
HY-125946 Latanoprost lactone diol 99.86% 否
HY-129397S 2,3-Dinor-11β-prostaglandin F2α-d9 / 否
HY-12956B (5R)-Dinoprost / 否
HY-12956S1 Dinoprost-d9 / 否
HY-12956S2 Dinoprost-13C5 / 否
HY-129953 9α,11β-Prostaglandin F2α / 否
HY-129953A 5-trans Prostaglandin F2α / 否
HY-129953C 5-trans Prostaglandin F2α tromethamine / 否
HY-129953S 9α,11β-Prostaglandin F2α-d4 / 否
HY-129953S1 9α,11β-Prostaglandin F2α-d9 / 否
HY-130660 Prostaglandin F2α ethanolamide Agonist / 否
HY-131617 Prostaglandin F2α 1,11-lactone Control / 否
HY-131632 1a,1b-Dihomo prostaglandin F2α / 否
HY-132277 15-Keto Bimatoprost Control / 否
HY-136494 Fluprostenol / 否
HY-137024 15-Keto-PGA1 Activator / 否
HY-137119 (±)5-iPF2α-VI Control / 否
HY-137119A 8,12-iso-iPF2α-VI Control / 否
HY-137412 PGF2α 1,15-lactone / 否
HY-137504 20-ethyl Prostaglandin F2α / 否
HY-137544 16-Phenyl tetranor Prostaglandin F2α / 否
HY-138244 8-iso Prostaglandin F2β / 否
HY-139063 16-Phenoxy tetranor prostaglandin F2α / 否
HY-139119 Prostaglandin F2α dimethyl amide Antagonist / 否
HY-139121 15(R)-17-Phenyl trinor Prostaglandin F2α Agonist / 否
HY-149588 17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester / 否
HY-149749 Methylthiomcresol-C3-COOH / 否
HY-149770 CYP4A11/CYP4F2-IN-2 Inhibitor / 否
HY-149926 Cathepsin Inhibitor 3 / 否
HY-151190 cis-4-Br-2,5-F2-PCPA Inhibitor / 否
HY-151453 Topoisomerase IIα-IN-4 / 否
HY-154606 2'-F-2'-ara-N2-ibu-dG Phosphoramidite / 否
HY-154854 BBDDL2059 Inhibitor / 否
HY-157292 2E-3-F16 / 否
HY-158450 FA2G2 glycan (G2F), 2-AB labelled / 否
HY-158459 A2G2F2 glycan / 否
HY-158478 FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AB labelled / 否
HY-158481 FA2[3]G1 & FA2[6]G1 glycan (G1F), 2-AA labelled / 否
HY-158499 FA2 glycan (G0F), 2-AA labelled / 否
HY-158500 FA2 glycan (G0F), 2-AB labelled / 否
HY-158595 15(R),19(R)-Hydroxy prostaglandin F2α / 否
HY-158937 15(R)-15-Methyl prostaglandin F2α methyl ester Control / 否
HY-162142 BB2-50F Inhibitor 99.52% 否
HY-163376 17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide / 否
HY-163552 Prostaglandin F2a/BSA / 否
HY-163709 PROTAC FAK degrader 2 Degrader / 否
HY-164141 GDP-D-Rha6F2 / 否
HY-D0160 ZnAF-2F / 否
HY-D0161 ZnAF-2F DA / 否
HY-E70487 Human CYP4F2,Low-Reductase+b5 / 否
HY-N12119 ent-Prostaglandin F2α / 否
HY-N12817 Anti-inflammatory agent 80 Inhibitor / 否
HY-N7614 Anemarrhenasaponin A2 / 否
HY-R00011 hsa-let-7f-2-3p mimic / 否
HY-R00011A hsa-let-7f-2-3p agomir / 否
HY-R02559 mmu-let-7f-2-3p mimic / 否
HY-R02559A mmu-let-7f-2-3p agomir / 否
HY-RI00011 hsa-let-7f-2-3p inhibitor / 否
HY-RI00011A hsa-let-7f-2-3p antagomir / 否
HY-RI02559 mmu-let-7f-2-3p inhibitor / 否
HY-RI02559A mmu-let-7f-2-3p antagomir / 否
HY-RS03480 CYP4F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04111 E2F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04630 F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04632 F2r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04633 F2r Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04634 F2RL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04635 F2rl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04636 F2rl1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04637 F2RL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04638 F2rl2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04639 F2rl2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04640 F2RL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04641 F2rl3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04642 F2rl3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05897 GTF2F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09542 NR2F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10898 POU2F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10901 POU3F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10905 POU4F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10911 POU5F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10913 POU6F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13206 SLC35F2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W006069 H-Phe(3,5-DiF)-OH 95.96% 否
HY-W399193 PGF2α 1,9-lactone Inhibitor / 否
HY-W746888 17-Phenyl trinor prostaglandin F2α diethyl amide / 否
HY-Y0110S 2-Naphthol-d8 / 否
HY-Y0110S1 2-Naphthol-d7 95.00% 否
HY-112284A Ebopiprant hydrochloride Antagonist / 否
HY-113209S2 8-Isoprostaglandin F2α-13C5 / 否
HY-114593 ent-8-iso Prostaglandin F2α / 否
HY-114695 Prostaglandin F2α-1-glyceryl ester / 否
HY-114841 ONO 207 / 否
HY-116679 17-trifluoromethylphenyl trinor Prostaglandin F2α / 否
HY-116889 15-Keto latanoprost acid / 否
HY-118520 16-Phenoxy tetranor prostaglandin F2α methyl ester / 否
HY-120982 (+)-15-epi Cloprostenol / 否
HY-124175 16-Phenoxy prostaglandin F2α ethyl amide / 否
HY-124243 N-Cyclopropyl methyl bimatoprost Agonist / 否
HY-137547 20-Hydroxy-PGF2α / 否
HY-139124 15(R)-15-Methyl Prostaglandin F2α / 否
HY-149554 17-Phenyl trinor Prostaglandin F2α dimethyl amide / 否
HY-N8085 Icariside F2 Inhibitor / 否
HY-W408869 8-iso-13,14-dihydro-15-keto Prostaglandin F2α / 否
HY-W472509 11-HETE Activator / 否
HY-W701877 Latanoprost tris(triethylsilyl) ether Control / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990597 HuGAL-F2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens F2 NCBI NCBI:2147
Canis familiaris F2 NCBI NCBI:100856539
Felis catus F2 NCBI NCBI:101090463
Macaca fascicularis F2 NCBI NCBI:102131020
Susscrofa domestica F2 NCBI
Leporidae F2 NCBI
Rattus norvegicus F2 NCBI NCBI:29251
Macaca mulatta F2 NCBI NCBI:712729
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