2. Gene
  3. Irak4 - interleukin-1 receptor-associated kinase 4 Gene

Irak4 - interleukin-1 receptor-associated kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白介素 1 受体相关激酶 4

种属: Rattus norvegicus

基因 ID: 300177 | 基因类型: protein coding

关于 Irak4

Primary_assembly 7: 125,682,488-125,717,837 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 52.5), Thymus (RPKM 38.7) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动 interleukin-1 受体结合活性；蛋白激酶结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与JNK级联；细胞因子介导的信号通路；和平滑肌细胞增殖的正调节。位于细胞外空间。脑缺血的生物标志物。该基因的人类直系同源物与原发性免疫缺陷病有关。与人 IRAK4（白细胞介素 1 受体相关激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable interleukin-1 receptor binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in JNK cascade; cytokine-mediated signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Irak4 基因产物(1)

mRNA Protein Name
NM_001106791.2 NP_001100261.2 interleukin-1 receptor-associated kinase 4
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in JNK cascade IMP
IMP: 通过突变表型推断
15890643 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
15890643 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
15890643 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
23073793 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Irak4 蛋白结构

Death_IRAK4

Death_IRAK4: cd08793 (8 - 107)

STKc_IRAK4

STKc_IRAK4: cd14158 (171 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

interleukin-1 receptor-associated kinase 4

相关产品

Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-19836 Zimlovisertib Inhibitor 99.94% Phase 2
HY-145483 KT-474 Inhibitor 99.27% Phase 2
HY-135317 Emavusertib Inhibitor 99.96% Phase 2
HY-139374 Zabedosertib Inhibitor 98.14% Phase 2
HY-160487 KME-2780 Inhibitor 98.94% Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 2
HY-135317B Emavusertib hydrochloride Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (45)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103017A JH-X-119-01 Inhibitor 99.03% 否
HY-18992 AS2444697 Inhibitor 99.12% 否
HY-147141 HS-276 Inhibitor 98.59% 否
HY-111101 AZ1495 Inhibitor 98.07% 否
HY-153188 JNJ-1013 Degrader 99.80% 否
HY-134911 HS-243 Inhibitor 99.88% 否
HY-129966 PROTAC IRAK4 degrader-1 Inhibitor 99.72% 否
HY-148290 KTX-951 Degrader 98.03% 否
HY-123854 PF-06426779 Inhibitor 99.89% 否
HY-153224 GLPG2534 Inhibitor 98.73% 否
HY-135382A PROTAC IRAK4 degrader-3 Inhibitor 97.22% 否
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.01% 否
HY-146112 IRAK4-IN-14 Inhibitor 99.01% 否
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% 否
HY-131903 HS271 Inhibitor 99.92% 否
HY-150735 IRAK4-IN-20 Inhibitor 96.05% 否
HY-143231 IRAK4-IN-8 Inhibitor / 否
HY-161620 DW18134 Inhibitor / 否
HY-150732 IRAK4-IN-18 Inhibitor / 否
HY-123956 HG-12-6 Inhibitor / 否
HY-150594 IRAK4-IN-17 Inhibitor / 否
HY-146113 IRAK4-IN-15 Inhibitor / 否
HY-150593 IRAK4-IN-16 Inhibitor / 否
HY-146111 IRAK4-IN-13 Inhibitor / 否
HY-155574 IRAK4-IN-27 Inhibitor / 否
HY-139317 PROTAC IRAK4 degrader-6 Inhibitor / 否
HY-148276 KTX-497 / 否
HY-148277 KTX-612 / 否
HY-148238 GNE-2256 Inhibitor / 否
HY-146072 IRAK4-IN-11 Inhibitor / 否
HY-158374 BIO-8169 Inhibitor / 否
HY-162359 BIO-7488 Inhibitor 99.44% 否
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / 否
HY-148275 KTX-955 Inhibitor / 否
HY-162641 AF-45 Inhibitor / 否
HY-146073 IRAK4-IN-12 Inhibitor / 否
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / 否
HY-143485 IRAK4-IN-9 Inhibitor / 否
HY-149345 IRAK4-IN-24 Inhibitor / 否
HY-150733 IRAK4-IN-19 Inhibitor / 否
HY-143486 IRAK4-IN-10 Inhibitor / 否
HY-160654 IRAK4 modulator-1 Modulator / 否
HY-168611 PROTAC IRAK4 ligand-4 Degrader / 否
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor / 否
HY-139315 PROTAC IRAK4 degrader-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Irak4 NCBI NCBI:51135
Mus musculus Irak4 NCBI NCBI:266632
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