GOLM1 - golgi membrane protein 1 Gene

中文名称：高尔基体膜蛋白 1

种属: Homo sapiens

同用名: GP73; HEL46; GOLPH2; C9orf155; PSEC0257; bA379P1.3

基因 ID: 51280 | 基因类型: protein coding

关于 GOLM1

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:86,026,146-86,100,149 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in stomach (RPKM 210.4), colon (RPKM 117.5) and 14 other tissues.

功能概要

高尔基复合体在内质网输出的蛋白质的分类和修饰中起着关键作用。该基因编码的蛋白质是 II 型高尔基体跨膜蛋白。它处理在粗面内质网中合成的蛋白质，并协助通过高尔基体运输蛋白质货物。已观察到该基因的表达响应于病毒感染而上调。已经针对该基因描述了编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2009 年 9 月]

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral Infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]

GOLM1 基因产物(2)

mRNA	Protein	Name
NM_016548.4	NP_057632.2	Golgi membrane protein 1
NM_177937.3	NP_808800.1	Golgi membrane protein 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21280149	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

Golgi membrane protein 1

epididymis luminal protein 46

GOLM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GOLM1	Q8NBJ4	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	SLC35B2	Homo sapiens	Q8TB61	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	TMEM109	Homo sapiens	Q9BVC6	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	TMUB1	Homo sapiens	Q9BVT8	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	CLDND2	Homo sapiens	Q8NHS1	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	SLC5A4	Homo sapiens	Q9NY91	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	ST6GAL2	Homo sapiens	Q96JF0-2	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	SLCO3A1	Homo sapiens	Q9UIG8-2	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
种属内	GOLM1	Q8NBJ4	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
种属内	GOLM1	Q8NBJ4	TMEM176A	Homo sapiens	Q96HP8	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	CNPY3	Homo sapiens	Q9BT09	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Anti Bait CoIP	27569582
种属内	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27569582
种属内	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Confocal	27569582
种属内	GOLM1	Q8NBJ4	EGFR	Homo sapiens	P00533	Pull Down	27569582
种属内	GOLM1	Q8NBJ4	THSD7A	Homo sapiens	Q9UPZ6	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	FUT9	Homo sapiens	Q9Y231	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	NDUFV2	Homo sapiens	P19404	Y2H Prey Pooling	32296183
种属内	GOLM1	Q8NBJ4	NDUFV2	Homo sapiens	P19404	Y2H Array	32296183
种属内	GOLM1	Q8NBJ4	NEU1	Homo sapiens	Q99519	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	TMEM98	Homo sapiens	Q9Y2Y6	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
种属内	GOLM1	Q8NBJ4	INSIG2	Homo sapiens	Q9Y5U4	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GOLM1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70879	GOLM1 Protein, Human (HEK293, His)	Q8NBJ4-1 (S36-L401)	≥95%
HY-P72209	GOLM1 Protein, Human (His)	Q8NBJ4-1 (S36-L401)	≥95%
HY-P72209A	GOLM1 Protein, Human (His, Solution)	Q8NBJ4-1 (S36-L401)	≥95%

GOLM1 抗体

目录号	产品名	应用	反应物种
HY-P83002	GOLPH2 Antibody (YA2747)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Autoimmune Hepatitis

Aih	Hepatitis, Autoimmune
Autoimmune Chronic Active Hepatitis	Autoimmune Hepatitis With Centrilobular Necrosis
Autoimmune Chronic Hepatitis	Hepatitis Autoimmune

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Spinocerebellar Ataxia 44

SCA44

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05592	GOLM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990421	Anti-GOLM1 Antibody		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	GOLM1	VGNC	VGNC:41345
Mus musculus	GOLM1	MGD	MGI:1917329
Rattus norvegicus	GOLM1	RGD	RGD:1589384
Macaca mulatta	GOLM1	VGNC	VGNC:72946
Felis catus	GOLM1	VGNC	VGNC:62643
Bos taurus	GOLM1	VGNC	VGNC:29491
Others	GOLM1	NCBI

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