2. Gene
  3. GOPC - golgi associated PDZ and coiled-coil motif containing Gene

GOPC - golgi associated PDZ and coiled-coil motif containing Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含高尔基体相关的 PDZ 和卷曲螺旋基序

种属: Homo sapiens

同用名: CAL; FIG; PIST; GOPC1; dJ94G16.2

基因 ID: 57120 | 基因类型: protein coding

关于 GOPC

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,560,269-117,602,511 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and is associated with 55 phenotypes. Ubiquitous expression in thyroid (RPKM 17.5), endometrium (RPKM 15.4) and 25 other tissues.

功能概要

该基因编码具有 PDZ 结构域的高尔基体蛋白。 PDZ 结构域是球状的，包含它们的蛋白质通过靠近 C 末端的短基序与其他蛋白质结合。缺乏直向同源蛋白的小鼠患有圆精子症并且不育。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind Other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GOPC 基因产物(2)

mRNA Protein Name
NM_001017408.3 NP_001017408.1 Golgi-associated PDZ and coiled-coil motif-containing protein isoform b
NM_020399.4 NP_065132.1 Golgi-associated PDZ and coiled-coil motif-containing protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11707463 GOA
enables molecular sequestering activity IMP
IMP: 通过突变表型推断
11707463 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11384996 GOA
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
11707463 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of anion channel activity IMP
IMP: 通过突变表型推断
11707463 GOA
involved in negative regulation of protein localization to cell surface IMP
IMP: 通过突变表型推断
11707463 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
11384996 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11707463 GOA
located in membrane IDA
IDA: 通过直接分析推断
11707463 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
18468998 GOA
located in trans-Golgi network transport vesicle IDA
IDA: 通过直接分析推断
11707463 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GOPC 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (291 - 367)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
蛋白主名 其他名称

Golgi-associated PDZ and coiled-coil motif-containing protein

CFTR-associated ligand

GOPC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GOPC Q9HD26 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
种属内
GOPC Q9HD26 CCDC102B Homo sapiens Q68D86
Validated Y2H
25416956
种属内
GOPC Q9HD26 C17orf67 Homo sapiens Q0P5P2
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 PWWP3A Homo sapiens Q2TAK8-2
Validated Y2H
25416956
种属内
GOPC Q9HD26 PWWP3A Homo sapiens Q2TAK8-2
Y2H Array
25416956
种属内
GOPC Q9HD26 ZNF509 Homo sapiens Q32MK9
Validated Y2H
25416956
种属内
GOPC Q9HD26 ZNF509 Homo sapiens Q32MK9
Y2H Array
25416956
种属内
GOPC Q9HD26 LCLAT1 Homo sapiens Q6UWP7
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 PID1 Homo sapiens Q7Z2X4
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 ZNF564 Homo sapiens Q8TBZ8
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 ZNF564 Homo sapiens Q8TBZ8
Validated Y2H
25416956
种属内
GOPC Q9HD26 ZNF564 Homo sapiens Q8TBZ8
Y2H Array
25416956
种属内
GOPC Q9HD26 MORN4 Homo sapiens Q8WVZ3
Validated Y2H
25416956
种属内
GOPC Q9HD26 RNF220 Homo sapiens Q9BWG1
Validated Y2H
25416956
种属内
GOPC Q9HD26 RNF220 Homo sapiens Q9BWG1
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 AKIRIN1 Homo sapiens Q9H9L7
Validated Y2H
25416956
种属内
GOPC Q9HD26 HEL-S-42 Homo sapiens V9HWD0
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 HEL-S-42 Homo sapiens V9HWD0
Validated Y2H
25416956
种属内
GOPC Q9HD26 VTN Homo sapiens P04004
Validated Y2H
25416956
种属内
GOPC Q9HD26 VTN Homo sapiens P04004
Y2H Array
25416956
种属内
GOPC Q9HD26 VTN Homo sapiens P04004
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 PARK7 Homo sapiens Q99497
Validated Y2H
25416956
种属内
GOPC Q9HD26 SSNA1 Homo sapiens O43805
Anti Tag CoIP
33961781
种属内
GOPC Q9HD26 SSNA1 Homo sapiens O43805
Validated Y2H
25416956
种属内
GOPC Q9HD26 DPYD Homo sapiens Q12882
Y2H Array
25416956
种属内
GOPC Q9HD26 DPYD Homo sapiens Q12882
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 ZBTB49 Homo sapiens Q6ZSB9
Y2H Array
29892012
种属内
GOPC Q9HD26 ZBTB49 Homo sapiens Q6ZSB9
Y2H Array
31515488
种属内
GOPC Q9HD26 ZBTB49 Homo sapiens Q6ZSB9
Validated Y2H
25416956
种属内
GOPC Q9HD26 HCK Homo sapiens P08631
Validated Y2H
25416956
种属内
GOPC Q9HD26 HCK Homo sapiens P08631
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 HCK Homo sapiens P08631
Y2H Array
25416956
种属内
GOPC Q9HD26 CFTR Homo sapiens P13569
Anti Tag CoIP
28360110
种属内
GOPC Q9HD26 CFTR Homo sapiens P13569
Pull Down
12471024
种属内
GOPC Q9HD26 FOSL2 Homo sapiens P15408
Y2H Array
25416956
种属内
GOPC Q9HD26 FOSL2 Homo sapiens P15408
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 FOSL2 Homo sapiens P15408
Validated Y2H
25416956
种属内
GOPC Q9HD26 MYOCD Homo sapiens Q8IZQ8
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 ZSCAN1 Homo sapiens Q8NBB4
Y2H Array
25416956
种属内
GOPC Q9HD26 SLC25A18 Homo sapiens Q9H1K4
Validated Y2H
25416956
种属内
GOPC Q9HD26 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
25416956
种属内
GOPC Q9HD26 ZNF587 Homo sapiens Q96SQ5
Y2H Array
25416956
种属内
GOPC Q9HD26 SEMA4G Homo sapiens Q9NTN9
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 FAM90A1 Homo sapiens Q86YD7
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
种属内
GOPC Q9HD26 RNF183 Homo sapiens Q96D59
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
25416956
种属内
GOPC Q9HD26 BATF Homo sapiens Q16520
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 BATF Homo sapiens Q16520
Validated Y2H
25416956
种属内
GOPC Q9HD26 JUN Homo sapiens P05412
Display Tech
20195357
种属内
GOPC Q9HD26 SPATA8 Homo sapiens Q6RVD6
Y2H Array
25416956
种属内
GOPC Q9HD26 SPATA8 Homo sapiens Q6RVD6
Y2H Prey Pooling
25416956
种属内
GOPC Q9HD26 MYLK Homo sapiens Q15746
Y2H Array
25416956
种属内
GOPC Q9HD26 STARD3 Homo sapiens Q14849
Validated Y2H
25416956
种属内
GOPC Q9HD26 STARD3 Homo sapiens Q14849
Y2H Prey Pooling
25416956
种属间
GOPC Q9HD26 mGluR1a Rattus norvegicus Q9R0W0
IF
19027007
种属间
GOPC Q9HD26 mGluR1a Rattus norvegicus Q9R0W0
Pull Down
19027007
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GOPC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73708 PIST Protein, Human (His) Q9HD26-1 (I286-Y462) ≥95%

GOPC 抗体

目录号 产品名 应用 反应物种
HY-P81902 PIST Antibody (YA1647) WB, IHC-P, ICC/IF, IP, FC Human, Mouse

关联疾病

疾病名称 别名
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Acute Laryngitis

Acute Laryngitis Nos

Laryngeal Inflammation

Laryngitis Nos

Larynx Inflammation
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Childhood Angiosarcoma

Paediatric Angiosarcoma

Paediatric Hemangiosarcoma

Pediatric Angiosarcoma

Pediatric Hemangiosarcoma
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
Neonatal Candidiasis

Neonatal Candida Infection

Neonatal Monilia Infection

Neonatal Moniliasis
Sclerosing Hepatic Carcinoma

Sclerosing Hepatocellular Carcinoma
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05599 GOPC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus GOPC VGNC VGNC:97446
Bos taurus GOPC VGNC VGNC:53793
Mus musculus GOPC MGD MGI:2149946
Rattus norvegicus GOPC RGD RGD:1309512
Canis familiaris GOPC VGNC VGNC:49713
Others GOPC NCBI
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