Trpv4 - transient receptor potential cation channel, subfamily V, member 4 Gene

种属: Mus musculus

同用名: Trp12; VRL-2; VROAC; OTRPC4; VR-OAC; 0610033B08Rik

基因 ID: 63873 | 基因类型: protein coding

关于 Trpv4

功能概要

Enables several functions, including SH2 domain binding activity; Calcium Channel activity; and osmosensor activity. Involved in several processes, including cellular hypotonic salinity response; positive regulation of MAPK cascade; and positive regulation of cytokine production. Acts upstream of or within several processes, including hyperosmotic salinity response; osmosensory signaling pathway; and vasopressin secretion. Located in adherens junction; cilium; and plasma membrane. Is expressed in several structures, including autopod; brain; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpv4 基因产物(1)

mRNA	Protein	Name
NM_022017.3	NP_071300.2	transient receptor potential cation channel subfamily V member 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SH2 domain binding	IPI IPI: 通过物理相互作用推断	12538589	MGI
enables calcium channel activity	IDA IDA: 通过直接分析推断	11025659	MGI
enables calcium channel activity	IMP IMP: 通过突变表型推断	18174177	MGI
enables osmosensor activity	IDA IDA: 通过直接分析推断	11025659	MGI
enables osmosensor activity	IMP IMP: 通过突变表型推断	12777254	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	14517216	MGI
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	12538589	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcium ion import	IDA IDA: 通过直接分析推断	12538589	MGI
involved in cell-cell junction assembly	IMP IMP: 通过突变表型推断	20413591	MGI
involved in cellular hypotonic response	IDA IDA: 通过直接分析推断	12538589	MGI
involved in cellular hypotonic salinity response	IMP IMP: 通过突变表型推断	23021218	MGI
involved in cellular response to heat	IMP IMP: 通过突变表型推断	18174177	MGI
involved in cellular response to osmotic stress	IMP IMP: 通过突变表型推断	18174177	MGI
involved in diet induced thermogenesis	IMP IMP: 通过突变表型推断	23021218	MGI
involved in energy homeostasis	IMP IMP: 通过突变表型推断	23021218	MGI
involved in glucose homeostasis	IMP IMP: 通过突变表型推断	23021218	MGI
acts upstream of or within hyperosmotic salinity response	IMP IMP: 通过突变表型推断	12777254	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: 通过突变表型推断	18174177	MGI
involved in negative regulation of brown fat cell differentiation	IMP IMP: 通过突变表型推断	23021218	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23021218	MGI
acts upstream of or within osmosensory signaling pathway	IDA IDA: 通过直接分析推断	11025659	MGI
involved in osmosensory signaling pathway	IDA IDA: 通过直接分析推断	12538589	MGI
acts upstream of or within osmosensory signaling pathway	IMP IMP: 通过突变表型推断	12777254	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of JNK cascade	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of inflammatory response	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of macrophage inflammatory protein 1 alpha production	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: 通过突变表型推断	23021218	MGI
involved in positive regulation of vascular permeability	IMP IMP: 通过突变表型推断	23136043	MGI
involved in regulation of aerobic respiration	IMP IMP: 通过突变表型推断	23021218	MGI
NOT involved in regulation of p38MAPK cascade	IMP IMP: 通过突变表型推断	23021218	MGI
acts upstream of or within regulation of response to osmotic stress	IMP IMP: 通过突变表型推断	12777254	MGI
NOT involved in response to fatty acid	IMP IMP: 通过突变表型推断	23021218	MGI
involved in response to insulin	IMP IMP: 通过突变表型推断	23021218	MGI
NOT involved in response to lipopolysaccharide	IMP IMP: 通过突变表型推断	23021218	MGI
acts upstream of or within response to osmotic stress	IDA IDA: 通过直接分析推断	11025659	MGI
acts upstream of or within response to osmotic stress	IPI IPI: 通过物理相互作用推断	14517216	MGI
acts upstream of or within vasopressin secretion	IMP IMP: 通过突变表型推断	12777254	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in adherens junction	IDA IDA: 通过直接分析推断	20413591	MGI
located in cilium	IDA IDA: 通过直接分析推断	15858826	MGI
is active in plasma membrane	IDA IDA: 通过直接分析推断	11094154	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	12538589	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transient receptor potential cation channel subfamily V member 4

osm-9-like TRP channel 4	osmosensitive transient receptor potential channel 4
transient receptor potential protein 12	trpv4 channel
vanilloid receptor-like channel 2	vanilloid receptor-like protein 2
vanilloid receptor-related osmotically-activated

Trpv4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	Trpv4	Q9EPK8	UBC	Homo sapiens	P0CG48	Pull Down	17110928
种属内	Trpv4	Q9EPK8	Aqp4	Mus musculus	P55088	Anti Bait CoIP	21262839
种属间	Trpv4	Q9EPK8	PKD2	Homo sapiens	Q13563	Anti Bait CoIP	25114176
种属间	Trpv4	Q9EPK8	TRPC1	Homo sapiens	P48995	Anti Bait CoIP	25114176

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	Phase
HY-19765	GSK2798745	Inhibitor	99.80%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19608	GSK1016790A		99.79%	否
HY-100208	HC-067047	Antagonist	99.89%	否
HY-100720	GSK2193874	Antagonist	99.91%	否
HY-120691A	GSK205	Antagonist	99.47%	否
HY-101507	Zerencotrep	Inhibitor	99.40%	否
HY-19975	RN-1734	Antagonist	99.86%	否
HY-19976	RN-1747	Agonist	99.25%	否
HY-18662	RQ-00203078	Antagonist	99.84%	否
HY-N8264	Moringin	Agonist	99.95%	否
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	否
HY-114400	TRPV4 agonist-1 free base	Agonist	99.58%	否
HY-116291	4α-Phorbol 12,13-didecanoate	Agonist	99.30%	否
HY-110270	RN-9893	Antagonist	99.91%	否
HY-160603	PF-05214030	Antagonist	99.19%	否
HY-120963	N-Oleoyl Taurine		≥99.0%	否
HY-120962	N-Arachidonoyl Taurine	Activator	≥99.0%	否
HY-160900	RN-1665	Antagonist	99.93%	否
HY-120514	JNc-440		98.04%	否
HY-124001	N-Docosanoyl taurine	Activator	/	否
HY-114400A	TRPV4 agonist-1	Agonist	/	否
HY-110270A	RN-9893 hydrochloride	Antagonist	/	否
HY-142620	TRPV4 antagonist 3	Antagonist	/	否
HY-149823	TRPV4 antagonist 4	Antagonist	/	否
HY-162765	TRPV4-IN-5	Inhibitor	/	否
HY-P5315	eNOS pT495 decoy peptide	Activator	/	否
HY-RS15124	TRPV4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W721480	HC-067047 hydrochloride	Antagonist	/	否
HY-N2940	Bisandrographolide A	Activator	/	否
HY-112202	GSK3395879	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Trpv4	NCBI	NCBI:59341

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