2. Gene
  3. Sirt3 - sirtuin 3 Gene

Sirt3 - sirtuin 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 3

种属: Mus musculus

同用名: Sir2l3; 2310003L23Rik

基因 ID: 64384 | 基因类型: protein coding

关于 Sirt3

Chromosome 7: 140,443,579-140,462,222 reverse strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 36 phenotypes. Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 NAD 依赖性组蛋白脱乙酰酶活性（H3-K14 特异性）和序列特异性 DNA 结合活性。参与肽基-赖氨酸脱乙酰化；神经酰胺生物合成过程的正调控；和线粒体转录的正调控。在肽酰赖氨酸乙酰化和蛋白质脱乙酰化的负调节上游或负调节中起作用。位于线粒体内膜和线粒体基质中。部分含蛋白质复合物。以多种结构表达，包括大脑；鳃弓;内分泌腺;泌尿生殖系统；以及肝脏和胆道系统。用于研究腹部肥胖-代谢综合征。与人类 SIRT3（sirtuin 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD-dependent histone deacetylase activity (H3-K14 specific) and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (Sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]

Sirt3 基因产物(3)

mRNA Protein Name
NM_022433.2 NP_071878.2 NAD-dependent protein deacetylase sirtuin-3 isoform 1
NM_001177804.1 NP_001171275.1 NAD-dependent protein deacetylase sirtuin-3 isoform 3
NM_001127351.1 NP_001120823.1 NAD-dependent protein deacetylase sirtuin-3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
16790548 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21720390 MGI
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
21858060 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23283301 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of peptidyl-lysine acetylation IDA
IDA: 通过直接分析推断
17923681 MGI
acts upstream of or within negative regulation of peptidyl-lysine acetylation IMP
IMP: 通过突变表型推断
17923681 MGI
involved in peptidyl-lysine deacetylation IDA
IDA: 通过直接分析推断
26620563 MGI
involved in positive regulation of ceramide biosynthetic process IDA
IDA: 通过直接分析推断
26620563 MGI
involved in positive regulation of mitochondrial transcription IMP
IMP: 通过突变表型推断
23283301 MGI
acts upstream of or within protein deacetylation IMP
IMP: 通过突变表型推断
23576753 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
11056054 MGI
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
18054327 MGI
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
17923681 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
17923681 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
23283301 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sirt3 蛋白结构

SIRT1

SIRT1: cd01408 (0 - 230)

  • 0
  • 100
  • 200
  • 257 a.a.
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-3

NAD-dependent deacetylase sirtuin-3

SIR2-like protein 3

SIRT3L mitochondrial

mSIR2L3

mitochondrial protein lysine deacetylase

regulatory protein SIR2 homolog 3

silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0130A Perindopril erbumine 99.98% 是
HY-B0130 Perindopril 98.01% 是
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-123033A Nicotinamide riboside chloride Activator 99.90% Phase 4
HY-123033 Nicotinamide riboside Activator / Phase 4
HY-123033B Nicotinamide riboside tartrate Activator / Phase 4
HY-123033C Nicotinamide riboside malate Activator / Phase 4
Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108331 3-TYP Inhibitor 99.96% 否
HY-100578 AGK2 Inhibitor 99.62% 否
HY-N1511 Ganoderic acid D Activator 99.81% 否
HY-15510 Tenovin-6 Inhibitor 98.33% 否
HY-136199 SIRT1-IN-1 Inhibitor 98.19% 否
HY-N6675 Gardenia yellow Activator / 否
HY-16616 SIRT-IN-2 Inhibitor 98.08% 否
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% 否
HY-151519 SIRT2-IN-9 Inhibitor 99.45% 否
HY-N2673 5-Heptadecylresorcinol Activator 99.83% 否
HY-16615 SIRT-IN-1 Inhibitor 98.58% 否
HY-111329 JGB1741 Inhibitor 99.05% 否
HY-111303 CHIC35 Inhibitor / 否
HY-160617 SIRT2-IN-14 Inhibitor / 否
HY-161920 SIRT3-IN-1 Inhibitor / 否
HY-118343 AC-93253 Inhibitor / 否
HY-155784 SPC-180002 Inhibitor / 否
HY-160944 hsa62 Inhibitor / 否
HY-163987 SIRT3 activator 2 Activator / 否
HY-150727 SIRT5 inhibitor 4 Inhibitor / 否
HY-146013 Sirt1/2-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirt3 NCBI NCBI:23410
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