2. Gene
  3. UBE2I - ubiquitin conjugating enzyme E2 I Gene

UBE2I - ubiquitin conjugating enzyme E2 I Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素结合酶 E2 I

种属: Homo sapiens

同用名: P18; UBC9; C358B7.1

基因 ID: 7329 | 基因类型: protein coding

关于 UBE2I

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,309,152-1,327,017 (from NCBI)

This gene has 24 transcripts (splice variants), 243 orthologues and 24 paralogues. Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。已发现该基因有四种编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UBE2I 基因产物(4)

mRNA Protein Name
NM_003345.5 NP_003336.1 SUMO-conjugating enzyme UBC9
NM_194259.3 NP_919235.1 SUMO-conjugating enzyme UBC9
NM_194260.3 NP_919236.1 SUMO-conjugating enzyme UBC9
NM_194261.3 NP_919237.1 SUMO-conjugating enzyme UBC9
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RING-like zinc finger domain binding IPI
IPI: 通过物理相互作用推断
19407830 GOA
enables SUMO conjugating enzyme activity IDA
IDA: 通过直接分析推断
19955185 GOA
enables SUMO transferase activity EXP
EXP: 通过实验结果推断
11877416 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
17087506 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9885291 GOA
enables small protein activating enzyme binding IPI
IPI: 通过物理相互作用推断
15660128 GOA
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
20215116 GOA
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
19744555 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16631117 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19955185 GOA
involved in nuclear export EXP
EXP: 通过实验结果推断
27160050 GOA
involved in positive regulation of SUMO transferase activity IDA
IDA: 通过直接分析推断
19955185 GOA
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20023705 GOA
involved in protein sumoylation IDA
IDA: 通过直接分析推断
15660128 GOA
involved in protein sumoylation IMP
IMP: 通过突变表型推断
26620705 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
9885291 GOA
part of SUMO ligase complex IPI
IPI: 通过物理相互作用推断
22194619 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9223278 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9223278 GOA
part of transferase complex IDA
IDA: 通过直接分析推断
19955185 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBE2I 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 151)

  • 0
  • 100
  • 158 a.a.
蛋白主名 其他名称

SUMO-conjugating enzyme UBC9

RING-type E3 SUMO transferase UBC9

UBE2I 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UBE2I P63279 SUMO1P1 Homo sapiens G2XKQ0
Y2H Prey Pooling
25416956
Intra UBE2I P63279 SUMO1P1 Homo sapiens G2XKQ0
Validated Y2H
25416956
Intra UBE2I P63279 SUMO1P1 Homo sapiens G2XKQ0
Y2H Array
25416956
Intra UBE2I P63279 SOX10 Homo sapiens P56693
Anti Tag CoIP
16494873
Intra UBE2I P63279 SETX Homo sapiens Q7Z333
Y2H
24244371
Intra UBE2I P63279 RWDD3 Homo sapiens Q9Y3V2
Pull Down
17956732
Intra UBE2I P63279 RWDD3 Homo sapiens Q9Y3V2
Confocal
17956732
Intra UBE2I P63279 RNF111 Homo sapiens Q6ZNA4
Y2H Array
19549727
Intra UBE2I P63279 RNF111 Homo sapiens Q6ZNA4
Y2H Prey Pooling
25416956
Intra UBE2I P63279 GMCL1 Homo sapiens Q96IK5
BFG-2H
27107012
Intra UBE2I P63279 EDARADD Homo sapiens Q8WWZ3
Y2H Prey Pooling
25416956
Intra UBE2I P63279 HDAC4 Homo sapiens P56524
Y2H
16166628
Intra UBE2I P63279 HDAC4 Homo sapiens P56524
Anti Tag CoIP
16166628
Intra UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H
21988832
Intra UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H
15231748
Intra UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H Array
31515488
Intra UBE2I P63279 SMAD4 Homo sapiens Q13485
Y2H Array
29892012
Intra UBE2I P63279 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
21988832
Intra UBE2I P63279 TFAP2A Homo sapiens P05549
Pull Down
24835590
Intra UBE2I P63279 TFAP2A Homo sapiens P05549
Y2H
12072434
Intra UBE2I P63279 PIAS2 Homo sapiens O75928
Validated Y2H
25416956
Intra UBE2I P63279 PIAS2 Homo sapiens O75928
Y2H Pooling
16189514
Intra UBE2I P63279 PIAS2 Homo sapiens O75928
Y2H Array
25416956
Intra UBE2I P63279 TP53 Homo sapiens P04637
Anti Tag CoIP
15327968
Intra UBE2I P63279 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
25416956
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
X-Ray Diffraction
16732283
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
GMS
16732283
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Tag CoIP
33961781
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Pull Down
17036045
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Tag CoIP
26496610
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Y2H
19549727
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Tag CoIP
28514442
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Anti Bait CoIP
17353931
Intra UBE2I P63279 RANGAP1 Homo sapiens P46060
Confocal
21988832
Intra UBE2I P63279 SUMO2 Homo sapiens P61956
Anti Tag CoIP
33961781
Intra UBE2I P63279 SUMO2 Homo sapiens P61956
GMS
17491593
Intra UBE2I P63279 SUMO2 Homo sapiens P61956
Anti Tag CoIP
28514442
Intra UBE2I P63279 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Cross UBE2I P63279 E1 Bovine papillomavirus P03116
Y2H
10871618
Intra UBE2I P63279 UBA1 Homo sapiens P22314
Pull Down
17956732
Intra UBE2I P63279 BHLHE40 Homo sapiens O14503
Anti Tag CoIP
11278694
Intra UBE2I P63279 BHLHE40 Homo sapiens O14503
Yeast Display
11278694
Intra UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Bait CoIP
17353931
Intra UBE2I P63279 UBA2 Homo sapiens Q9UBT2
NMR
17643372
Intra UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
26496610
Intra UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
33961781
Intra UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Anti Tag CoIP
28514442
Intra UBE2I P63279 UBA2 Homo sapiens Q9UBT2
Sumoylase Assay
17643372
Intra UBE2I P63279 ZCCHC7 Homo sapiens Q8N3Z6
Validated Y2H
25416956
Intra UBE2I P63279 ZCCHC7 Homo sapiens Q8N3Z6
Y2H Array
25416956
Intra UBE2I P63279 ZCCHC7 Homo sapiens Q8N3Z6
Y2H Prey Pooling
25416956
Intra UBE2I P63279 ELK1 Homo sapiens P19419
Pull Down
17036045
Intra UBE2I P63279 ELK1 Homo sapiens P19419
Anti Tag CoIP
23395904
Intra UBE2I P63279 ELK1 Homo sapiens P19419
Enzymatic Study
17036045
Intra UBE2I P63279 ELK1 Homo sapiens P19419
Anti Bait CoIP
17036045
Intra UBE2I P63279 ELK1 Homo sapiens P19419
Pull Down
23395904
Intra UBE2I P63279 ZNF451 Homo sapiens Q9Y4E5
Y2H Pooling
20936779
Intra UBE2I P63279 ZNF451 Homo sapiens Q9Y4E5
Y2H Pooling
16189514
Intra UBE2I P63279 ZNF451 Homo sapiens Q9Y4E5
Y2H
21516116
Intra UBE2I P63279 IPO13 Homo sapiens O94829
Pull Down
21139563
Intra UBE2I P63279 CHMP4B Homo sapiens Q9H444
Y2H Pooling
16189514
Intra UBE2I P63279 CHMP4B Homo sapiens Q9H444
Y2H
16730941
Cross UBE2I P63279 N Human SARS coronavirus P59595
Confocal
17037517
Cross UBE2I P63279 N Human SARS coronavirus P59595
Pull Down
16998888
Intra UBE2I P63279 DAXX Homo sapiens Q9UER7
Y2H
11112409
Intra UBE2I P63279 DAXX Homo sapiens Q9UER7
Anti Tag CoIP
23395904
Intra UBE2I P63279 DNMT3B Homo sapiens Q9UBC3
Y2H
11735126
Intra UBE2I P63279 DNMT3B Homo sapiens Q9UBC3
Pull Down
11735126
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
GMS
17491593
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
Comigration in SDS
18264111
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
Anti Bait CoIP
17353931
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
Comigration in SDS
16732283
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
Pull Down
17956732
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
ITC
17491593
Intra UBE2I P63279 SUMO1 Homo sapiens P63165
Anti Tag CoIP
26496610
Intra UBE2I P63279 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Tag CoIP
26496610
Intra UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Tag CoIP
33961781
Intra UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Bait CoIP
17353931
Intra UBE2I P63279 RANBP2 Homo sapiens P49792
Anti Tag CoIP
28514442
Cross UBE2I P63279 LMP1 Epstein-Barr virus P03230
Anti Tag CoIP
21795333
Cross UBE2I P63279 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Y2H
21911577
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2I 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71403 UBE2I Protein, Human (GST) P63279 (M1-S158) ≥95%

关联疾病

疾病名称 别名
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15349 UBE2I Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UBE2I VGNC VGNC:99624
Canis familiaris UBE2I VGNC VGNC:54084
Bos taurus UBE2I VGNC VGNC:36584
Mus musculus UBE2I MGD MGI:107365
Felis catus UBE2I VGNC VGNC:80700
Rattus norvegicus UBE2I RGD RGD:3926
Others UBE2I NCBI
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