2. Gene
  3. USP4 - ubiquitin specific peptidase 4 Gene

USP4 - ubiquitin specific peptidase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 4

种属: Homo sapiens

同用名: UNP; Unph

基因 ID: 7375 | 基因类型: protein coding

关于 USP4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,277,144-49,340,053 (from NCBI)

This gene has 14 transcripts (splice variants), 140 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 15.1), bone marrow (RPKM 14.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种蛋白酶，可使目标蛋白质 (如 ADORA2A 和 TRIM21) 去泛素化。编码的蛋白质在细胞核和细胞质之间穿梭，并参与维持内质网的操作保真度。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is a Protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP4 基因产物(3)

mRNA Protein Name
NM_001251877.2 NP_001238806.1 ubiquitin carboxyl-terminal hydrolase 4 isoform c
NM_003363.4 NP_003354.2 ubiquitin carboxyl-terminal hydrolase 4 isoform a
NM_199443.3 NP_955475.1 ubiquitin carboxyl-terminal hydrolase 4 isoform b

USP4 蛋白结构

DUSP

DUSP: DUSP domain (31 - 122)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (140 - 226)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (301 - 920)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 4

deubiquitinating enzyme 4

关联疾病

疾病名称 别名
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I

TRPS1

Trichorhinophalangeal Syndrome Type I

Trps I

Trichorhinophalangeal Syndrome Type 1

Type I Trichorhinophalangeal Syndrome

Giedion Syndrome

Trp Syndrome

Tricho-Rhino-Phalangeal Syndrome 1

Trichorhinophalangeal Syndrome, Type Iii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13814 PR-619 99.38% 否
HY-103435 Vialinin A Inhibitor 99.89% 否
HY-RS15551 USP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus USP4 VGNC VGNC:66886
Bos taurus USP4 VGNC VGNC:36729
Macaca mulatta USP4 VGNC VGNC:78416
Rattus norvegicus USP4 RGD RGD:1587387
Mus musculus USP4 MGD MGI:98905
Canis familiaris USP4 VGNC VGNC:48195
Others USP4 NCBI
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