1. Gene
  2. ZNF185 - zinc finger protein 185 with LIM domain Gene

ZNF185 - zinc finger protein 185 with LIM domain Gene

中文名称:具有 LIM 结构域的锌指蛋白 185

种属: Homo sapiens

同用名: SCELL

基因 ID: 7739 | 基因类型: protein coding

关于 ZNF185

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,898,067-152,973,481 (from NCBI)

This gene has 11 transcripts (splice variants), 149 orthologues and 1 paralogue. Biased expression in esophagus (RPKM 112.2), skin (RPKM 20.8) and 4 other tissues.

功能概要

锌指蛋白结合核酸并在各种细胞功能中发挥重要作用,包括细胞增殖、分化和凋亡。该基因编码 LIM 结构域锌指蛋白。 LIM 结构域由两个连续的锌指结构域组成,由两个氨基酸残基的疏水接头隔开。 LIM 结构域介导蛋白质:蛋白质相互作用。已鉴定出编码不同亚型的多个可变剪接转录本变体。[RefSeq 提供,2010 年 5 月]

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and Apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

ZNF185 基因产物(10)

mRNA Protein Name
NM_001178106.1 NP_001171577.1 zinc finger protein 185 isoform 1
NM_001178107.1 NP_001171578.1 zinc finger protein 185 isoform 2
NM_001178108.2 NP_001171579.1 zinc finger protein 185 isoform 3
NM_001178109.1 NP_001171580.1 zinc finger protein 185 isoform 5
NM_001178110.1 NP_001171581.1 zinc finger protein 185 isoform 6
NM_001178113.2 NP_001171584.1 zinc finger protein 185 isoform 7
NM_001178115.2 NP_001171586.1 zinc finger protein 185 isoform 9
NM_001388432.2 NP_001375361.1 zinc finger protein 185 isoform 3
NM_001395254.1 NP_001382183.1 zinc finger protein 185 isoform 10
NM_007150.3 NP_009081.2 zinc finger protein 185 isoform 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

zinc finger protein 185

P1-A

ZNF185 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF185 O15231 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra ZNF185 O15231 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra ZNF185 O15231 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra ZNF185 O15231 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra ZNF185 O15231 PRR23B Homo sapiens Q6ZRT6
Validated Y2H
32296183
Intra ZNF185 O15231 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra ZNF185 O15231 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra ZNF185 O15231 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra ZNF185 O15231 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra ZNF185 O15231 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra ZNF185 O15231 AARSD1 Homo sapiens Q9BTE6-2
Y2H Prey Pooling
32296183
Intra ZNF185 O15231 AARSD1 Homo sapiens Q9BTE6-2
Validated Y2H
32296183
Intra ZNF185 O15231 AARSD1 Homo sapiens Q9BTE6-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mast Cell Neoplasm

Mastocytoma

Mast Cell Proliferative Disease

Mast Cell Tumor

Benign Mastocytoma

Intussusception

Intussusception Of Intestine

Invagination Of Intestine Or Colon

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZNF185 VGNC VGNC:48670
Rattus norvegicus ZNF185 RGD RGD:1586351
Mus musculus ZNF185 MGD MGI:108095
Bos taurus ZNF185 VGNC VGNC:37219
Felis catus ZNF185 VGNC VGNC:67273