2. Gene
  3. ZP3 - zona pellucida glycoprotein 3 Gene

ZP3 - zona pellucida glycoprotein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：透明带糖蛋白 3

种属: Homo sapiens

同用名: ZPC; ZP3A; ZP3B; Zp-3; OOMD3

基因 ID: 7784 | 基因类型: protein coding

关于 ZP3

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,397,522-76,442,069 (from NCBI)

This gene has 7 transcripts (splice variants), 839 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 5.0), skin (RPKM 3.3) and 25 other tissues.

功能概要

透明带是包围卵母细胞和早期胚胎的细胞外基质。它主要由三种或四种糖蛋白组成，在受精和植入前发育过程中具有各种功能。由该基因编码的蛋白质是透明带的结构成分，在初级结合和诱导精子顶体反应中发挥作用。新生蛋白包含一个 N 端信号肽序列、一个保守的 ZP 结构域、一个 C 端共有弗林蛋白酶切割位点和一个跨膜结构域。据推测，弗林蛋白酶切割导致成熟蛋白从质膜释放，随后掺入透明带基质中。然而，基于小鼠研究，在此过程中弗林蛋白酶切割的要求仍然存在争议。该基因最后一个外显子的变异以前曾作为另一个 ZP3 位点的基础；然而，序列和文献回顾表明，人类基因组中只有一个全长 ZP3 基因座。编码二分转录本的另一个基因座指定 POMZP3 包含 ZP3 最后四个外显子的重复，包括上述变异，并紧密映射到该基因。[RefSeq 提供，2008 年 7 月]

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus Furin cleavage site, and a transmembrane domain. It is hypothesized that Furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for Furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

ZP3 基因产物(2)

mRNA Protein Name
NM_001110354.2 NP_001103824.1 zona pellucida sperm-binding protein 3 isoform 1 precursor
NM_007155.6 NP_009086.4 zona pellucida sperm-binding protein 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acrosin binding IPI
IPI: 通过物理相互作用推断
15950651 GOA
enables carbohydrate binding IDA
IDA: 通过直接分析推断
19246320 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
26879157 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15950651 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in binding of sperm to zona pellucida IDA
IDA: 通过直接分析推断
19246320 GOA
involved in binding of sperm to zona pellucida IGI
IGI: 通过遗传相互作用推断
9609824 GOA
involved in binding of sperm to zona pellucida IMP
IMP: 通过突变表型推断
19004505 GOA
involved in negative regulation of binding of sperm to zona pellucida IDA
IDA: 通过直接分析推断
18667750 GOA
involved in positive regulation of acrosomal vesicle exocytosis IDA
IDA: 通过直接分析推断
19246320 GOA
involved in positive regulation of acrosomal vesicle exocytosis IMP
IMP: 通过突变表型推断
19004505 GOA
involved in positive regulation of acrosome reaction IDA
IDA: 通过直接分析推断
11751269 GOA
involved in positive regulation of humoral immune response IDA
IDA: 通过直接分析推断
19004505 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
19246320 GOA
located in egg coat IDA
IDA: 通过直接分析推断
29895852 GOA
located in extracellular space IMP
IMP: 通过突变表型推断
19246320 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZP3 蛋白结构

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (45 - 301)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
蛋白主名 其他名称

zona pellucida sperm-binding protein 3

ZP3A/ZP3B

ZP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZP3 P21754 VDAC2 Homo sapiens P45880-3
Far-WB
23355646
种属内
ZP3 P21754 VDAC2 Homo sapiens P45880-3
Pull Down
23355646
种属内
ZP3 P21754 SPACA3 Homo sapiens Q8IXA5
Gal4 VP16 Complement
19945174
种属内
ZP3 P21754 UBAP2L Homo sapiens Q14157
Gal4 VP16 Complement
19945174
种属内
ZP3 P21754 ZP3 Homo sapiens P21754
X-Ray Diffraction
26879157
种属内
ZP3 P21754 PCDH17 Homo sapiens O14917
Gal4 VP16 Complement
19945174
种属内
ZP3 P21754 ENO1 Homo sapiens P06733
Far-WB
23355646
种属内
ZP3 P21754 GPX4 Homo sapiens P36969
Far-WB
23355646
种属内
ZP3 P21754 ACR Homo sapiens P10323
ELISA
15950651
种属内
ZP3 P21754 PKM Homo sapiens P14618-2
Far-WB
23355646
种属内
ZP3 P21754 MICALL1 Homo sapiens Q8N3F8
Gal4 VP16 Complement
19945174
种属内
ZP3 P21754 GAPDHS Homo sapiens O14556
Far-WB
23355646
种属内
ZP3 P21754 GSTM3 Homo sapiens P21266
Far-WB
23355646
种属内
ZP3 P21754 ZP3 Homo sapiens P21754
EM
26879157
种属内
ZP3 P21754 PCDH17 Homo sapiens O14917
Y2H
19945174
种属内
ZP3 P21754 ODF2 Homo sapiens Q5BJF6-5
Far-WB
23355646
种属内
ZP3 P21754 ZP3 Homo sapiens P21754
IR Spectrometry
26879157
种属内
ZP3 P21754 SPACA3 Homo sapiens Q8IXA5
Y2H
19945174
种属内
ZP3 P21754 P10323-PRO_0000027518 Homo sapiens P10323-PRO_0000027518
ELISA
15950651
种属内
ZP3 P21754 MICALL1 Homo sapiens Q8N3F8
Y2H
19945174
种属内
ZP3 P21754 UBAP2L Homo sapiens Q14157
Y2H
19945174
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ZP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71672 ZP3 Protein, Human (HEK293, His) P21754 (23Q-387V) ≥95%

关联疾病

疾病名称 别名
Oocyte Maturation Defect 3

OOMD3

Oocyte Maturation Defect, Type 3
Female Infertility Due To Zona Pellucida Defect
Infertility
Ovarian Disease

Ovarian Dysfunction

Ovarian Diseases

Ovarian Disorders

Disorder Of Endocrine Ovary
Epilepsy, Familial Temporal Lobe, 4

ETL4

Epilepsy, Occipitotemporal Lobe, And Migraine With Aura

Epolm

Familial Temporal Lobe Epilepsy 4

Occipitotemporal Lobe Epilepsy And Migraine With Aura
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
Cataract 1, Multiple Types

Cataract 1 Multiple Types

CTRCT1

Cataract 1, Multiple Types, With Or Without Microcornea

Czp1

Cae1

Pulverulent Zonular Cataract

Cataract, Duffy-Linked

Cataract, Zonular Pulverulent, 1

Duffy Linked Cataract

Zonular Pulverulent Cataract 1

Cataract Duffy-Linked

Cataract-Microcornea Syndrome

Cataract Zonular Pulverulent 1

Ccmc

Cznp

Czp

Zonular Nuclear Pulverulent Cataract

Cataract, Zonular Pulverulent-1

Zonular Pulverulent Cataract

Cataract, Zonular Pulverulent 1

Cataract Microcornea Syndrome
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Gaucher Disease, Type Iiic

Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome

Gaucher-Like Disease

GD3C

Gaucher'S Disease Type Iiic

Cardiovascular Gaucher Disease

Gaucher Disease Type 3c

Gaucher Disease 3c

Pseudo-Gaucher Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16188 ZP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ZP3 VGNC VGNC:108456
Felis catus ZP3 VGNC VGNC:107838
Mus musculus ZP3 MGD MGI:99215
Rattus norvegicus ZP3 RGD RGD:620606
Others ZP3 NCBI
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