2. Gene
  3. ZYX - zyxin Gene

ZYX - zyxin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：子欣

种属: Homo sapiens

同用名: ESP-2; HED-2

基因 ID: 7791 | 基因类型: protein coding

关于 ZYX

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,381,345-143,391,111 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 181 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues.

功能概要

粘着斑是富含肌动蛋白的结构，可使细胞粘附在细胞外基质上，参与信号转导的蛋白质复合物在此聚集。 Zyxin 是一种结合锌的磷蛋白，集中在粘着斑处和肌动蛋白细胞骨架上。 Zyxin 在其 C 端一半有一个 N 端富含脯氨酸的结构域和三个 LIM 结构域。富含脯氨酸的结构域可能与参与信号转导途径的蛋白质的 SH3 结构域相互作用，而 LIM 结构域可能参与蛋白质-蛋白质结合。 Zyxin 可能在信号转导通路中充当信使，介导粘附刺激的基因表达变化，并可能调节肌动蛋白束的细胞骨架组织。可变剪接导致编码相同亚型的多个转录变体。[RefSeq 提供，2008 年 7 月]

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin Cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

ZYX 基因产物(3)

mRNA Protein Name
NM_001010972.2 NP_001010972.1 zyxin isoform 1
NM_001362783.2 NP_001349712.1 zyxin isoform 2
NM_003461.5 NP_003452.1 zyxin isoform 1

ZYX 蛋白结构

LIM

LIM: LIM domain (384 - 439)

LIM

LIM: LIM domain (444 - 499)

LIM

LIM: LIM domain (504 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
蛋白主名 其他名称

zyxin

zyxin-2

重组 ZYX 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71673 ZYX Protein, Human (HEK293, His) Q15942 (A2-T572) ≥95%

关联疾病

疾病名称 别名
Lipomatosis, Multiple

Lipoma

Familial Multiple Lipomatosis

Lipomatosis, Familial Multiple

Benign Lipomatous Tumor

Lipomatous Neoplasm

Multiple Lipomatosis

Fml

Lipo

Benign Tumor Of Adipose Tissue

Lipomatous Tumor

Tumor Of Adipose Tissue

Neoplasms, Adipose Tissue

Lipomas
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10

Arrhythmogenic Right Ventricular Dysplasia 10

ARVD10

Arrhythmogenic Right Ventricular Cardiomyopathy 10

Arvc10

Familial Arrhythmogenic Right Ventricular Dysplasia 10

Dysplasia, Ventricular, Right, Arrhythmogenic, Type 10
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N12761 Penpaxilloids A Inhibitor / 否
HY-RS16215 ZYX Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZYX VGNC VGNC:51838
Felis catus ZYX VGNC VGNC:67394
Mus musculus ZYX MGD MGI:103072
Bos taurus ZYX VGNC VGNC:37395
Macaca mulatta ZYX VGNC VGNC:78917
Rattus norvegicus ZYX RGD RGD:620698
Others ZYX NCBI
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