2. Gene
  3. ZYX - zyxin Gene

ZYX - zyxin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：子欣

种属: Homo sapiens

同用名: ESP-2; HED-2

基因 ID: 7791 | 基因类型: protein coding

关于 ZYX

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,381,345-143,391,111 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 181 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 122.6), lung (RPKM 100.3) and 25 other tissues.

功能概要

粘着斑是富含肌动蛋白的结构，可使细胞粘附在细胞外基质上，参与信号转导的蛋白质复合物在此聚集。 Zyxin 是一种结合锌的磷蛋白，集中在粘着斑处和肌动蛋白细胞骨架上。 Zyxin 在其 C 端一半有一个 N 端富含脯氨酸的结构域和三个 LIM 结构域。富含脯氨酸的结构域可能与参与信号转导途径的蛋白质的 SH3 结构域相互作用，而 LIM 结构域可能参与蛋白质-蛋白质结合。 Zyxin 可能在信号转导通路中充当信使，介导粘附刺激的基因表达变化，并可能调节肌动蛋白束的细胞骨架组织。可变剪接导致编码相同亚型的多个转录变体。[RefSeq 提供，2008 年 7 月]

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin Cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

ZYX 基因产物(3)

mRNA Protein Name
NM_001010972.2 NP_001010972.1 zyxin isoform 1
NM_001362783.2 NP_001349712.1 zyxin isoform 2
NM_003461.5 NP_003452.1 zyxin isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10801818 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
24036928 GOA
involved in stress fiber assembly IMP
IMP: 通过突变表型推断
24036928 GOA
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
24036928 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
8940160 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
12417594 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24036928 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
18297730 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZYX 蛋白结构

LIM

LIM: LIM domain (384 - 439)

LIM

LIM: LIM domain (444 - 499)

LIM

LIM: LIM domain (504 - 568)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 572 a.a.
蛋白主名 其他名称

zyxin

zyxin-2

ZYX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZYX Q15942 b2r9y1_human Homo sapiens B2R9Y1
Y2H Prey Pooling
25416956
种属内
ZYX Q15942 b2r9y1_human Homo sapiens B2R9Y1
Validated Y2H
25416956
种属内
ZYX Q15942 ZNF512B Homo sapiens Q96KM6
Validated Y2H
32296183
种属内
ZYX Q15942 CASS4 Homo sapiens Q9NQ75-2
Validated Y2H
32296183
种属内
ZYX Q15942 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
32296183
种属内
ZYX Q15942 ENAH Homo sapiens Q8N8S7
Anti Tag CoIP
10801818
种属内
ZYX Q15942 ENAH Homo sapiens Q8N8S7
Anti Tag CoIP
33961781
种属内
ZYX Q15942 LATS1 Homo sapiens O95835
Y2H
10831611
种属内
ZYX Q15942 LATS1 Homo sapiens O95835
CoIP
10831611
种属内
ZYX Q15942 LATS1 Homo sapiens O95835
Pull Down
10831611
种属内
ZYX Q15942 EVL Homo sapiens Q9UI08-2
Validated Y2H
32296183
种属内
ZYX Q15942 EVL Homo sapiens Q9UI08-2
Complementation
32296183
种属内
ZYX Q15942 EVL Homo sapiens Q9UI08-2
Anti Tag CoIP
28514442
种属内
ZYX Q15942 RTN4IP1 Homo sapiens Q8WWV3
Validated Y2H
32296183
种属内
ZYX Q15942 PHF21A Homo sapiens Q96BD5
Y2H Array
25416956
种属内
ZYX Q15942 PHF21A Homo sapiens Q96BD5
Y2H Prey Pooling
25416956
种属内
ZYX Q15942 PHF21A Homo sapiens Q96BD5
Y2H Array
31515488
种属内
ZYX Q15942 IMP3 Homo sapiens Q9NV31
Validated Y2H
25416956
种属内
ZYX Q15942 IMP3 Homo sapiens Q9NV31
Validated Y2H
32296183
种属内
ZYX Q15942 IMP3 Homo sapiens Q9NV31
Y2H Array
25416956
种属内
ZYX Q15942 PDLIM5 Homo sapiens Q96HC4
Y2H Array
25416956
种属内
ZYX Q15942 PDLIM5 Homo sapiens Q96HC4
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ZYX 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71673 ZYX Protein, Human (HEK293, His) Q15942 (A2-T572) ≥95%

ZYX 抗体

目录号 产品名 应用 反应物种
HY-P82714 ZYX Antibody (YA2459) WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat

关联疾病

疾病名称 别名
Lipomatosis, Multiple

Lipoma

Familial Multiple Lipomatosis

Lipomatosis, Familial Multiple

Benign Lipomatous Tumor

Lipomatous Neoplasm

Multiple Lipomatosis

Fml

Lipo

Benign Tumor Of Adipose Tissue

Lipomatous Tumor

Tumor Of Adipose Tissue

Neoplasms, Adipose Tissue

Lipomas
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10

Arrhythmogenic Right Ventricular Dysplasia 10

ARVD10

Arrhythmogenic Right Ventricular Cardiomyopathy 10

Arvc10

Familial Arrhythmogenic Right Ventricular Dysplasia 10

Dysplasia, Ventricular, Right, Arrhythmogenic, Type 10
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N12761 Penpaxilloids A Inhibitor / 否
HY-RS16215 ZYX Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS19571 Zyx Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS26068 Zyx Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZYX VGNC VGNC:51838
Felis catus ZYX VGNC VGNC:67394
Mus musculus ZYX MGD MGI:103072
Bos taurus ZYX VGNC VGNC:37395
Macaca mulatta ZYX VGNC VGNC:78917
Rattus norvegicus ZYX RGD RGD:620698
Others ZYX NCBI
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