2. Gene
  3. SLBP - stem-loop binding protein Gene

SLBP - stem-loop binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：茎环结合蛋白

种属: Homo sapiens

同用名: HBP

基因 ID: 7884 | 基因类型: protein coding

关于 SLBP

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,692,731-1,712,319 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 30.6), bone marrow (RPKM 27.2) and 25 other tissues.

功能概要

该基因编码的蛋白质与复制依赖性组蛋白 mRNA 中的茎环结构结合。组蛋白 mRNA 不包含内含子或聚腺苷酸化信号，并通过核酸内切裂解进行加工。茎环结构对于高效加工至关重要，但该结构还控制组蛋白 mRNA 的运输、翻译和稳定性。蛋白质的表达在细胞周期中受到调节，在 G1 后期增加超过 10 倍。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

SLBP 基因产物(3)

mRNA Protein Name
NM_001306074.2 NP_001293003.1 histone RNA hairpin-binding protein isoform 2
NM_001306075.2 NP_001293004.1 histone RNA hairpin-binding protein isoform 3
NM_006527.4 NP_006518.1 histone RNA hairpin-binding protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23286197 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
16912046 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15829567 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cap-dependent translational initiation IDA
IDA: 通过直接分析推断
18025107 GOA
involved in mRNA transport IDA
IDA: 通过直接分析推断
19155325 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15829567 GOA
part of histone mRNA stem-loop binding complex IPI
IPI: 通过物理相互作用推断
23286197 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15829567 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLBP 蛋白结构

SLBP_RNA_bind

SLBP_RNA_bind: Histone RNA hairpin-binding protein RNA-binding domain (128 - 200)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

histone RNA hairpin-binding protein

hairpin binding protein, histone

SLBP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLBP Q14493 SLBP Homo sapiens Q14493
AFM
23286197
Intra SLBP Q14493 SLBP Homo sapiens Q14493
GMS
23286197
Intra SLBP Q14493 ERI1 Homo sapiens Q8IV48
GMS
23329046
Intra SLBP Q14493 ERI1 Homo sapiens Q8IV48
X-Ray Diffraction
23329046
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome

WHS

Chromosome 4p16.3 Deletion Syndrome

Wittwer Syndrome

4p- Syndrome

Pitt Syndrome

4p Deletion Syndrome

Distal Deletion 4p

Distal Monosomy 4p

Telomeric Deletion 4p

Prds

4p Syndrome

Chromosome 4p Syndrome

Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

Wolf Syndrome

Chromosome 4p Deletion Syndrome

Chromosome 4p Monosomy

Del Syndrome

Monosomy 4p

Partial Monosomy 4p

Chromosome 4 Short Arm Deletion
Chromosome 2q31.2 Deletion Syndrome
Blepharochalasis

Dermatolysis Palpebrarum

Adiposa Ptosis
Epiphyseal Dysplasia, Multiple, 2

EDM2

Multiple Epiphyseal Dysplasia 2

Dysplasia, Epiphyseal, Multiple, Type 2
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12984 SLBP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SLBP VGNC VGNC:46210
Macaca mulatta SLBP VGNC VGNC:77379
Rattus norvegicus SLBP RGD RGD:1584682
Felis catus SLBP VGNC VGNC:65179
Bos taurus SLBP VGNC VGNC:34658
Mus musculus SLBP MGD MGI:108402
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z