UBE2M - ubiquitin conjugating enzyme E2 M Gene

中文名称：泛素结合酶 E2 M

种属: Homo sapiens

同用名: UBC12; hUbc12; UBC-RS2

关于 UBE2M

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。编码的蛋白质与泛素样蛋白质 NEDD8 相连，NEDD8 可以与细胞蛋白质 (如 Cdc53/culin) 结合。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]