1. Gene
  2. DYRK1B - dual specificity tyrosine phosphorylation regulated kinase 1B Gene

DYRK1B - dual specificity tyrosine phosphorylation regulated kinase 1B Gene

中文名称:双特异性酪氨酸磷酸化调节激酶 1B

种属: Homo sapiens

同用名: MIRK; AOMS3

基因 ID: 9149 | 基因类型: protein coding

关于 DYRK1B

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,825,350-39,834,162 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 189 orthologues, 12 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues.

功能概要

该基因编码核定位蛋白激酶家族的一个成员。编码的蛋白质参与细胞周期的调节。该基因的表达可能在肿瘤细胞中发生改变,并且发现该基因的突变会导致腹部肥胖-代谢综合征 3。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 6 月]

This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

DYRK1B 基因产物(3)

mRNA Protein Name
NM_004714.3 NP_004705.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69
NM_006483.3 NP_006474.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65
NM_006484.3 NP_006475.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11980910 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
11980910 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
11980910 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adipose tissue development IMP
IMP: 通过突变表型推断
24827035 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11980910 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11980910 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DYRK1B 蛋白结构

Pkinase

Pkinase: Protein kinase domain (111 - 431)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 629 a.a.
蛋白主名 其他名称

dual specificity tyrosine-phosphorylation-regulated kinase 1B

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

DYRK1B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DYRK1B Q9Y463 GSC2 Homo sapiens O15499
Y2H Array
32296183
种属内
DYRK1B Q9Y463 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
种属内
DYRK1B Q9Y463 TROAP Homo sapiens Q12815
TAP
23602568
种属内
DYRK1B Q9Y463 TROAP Homo sapiens Q12815
Pull Down
32707033
种属内
DYRK1B Q9Y463 TROAP Homo sapiens Q12815
Anti Tag CoIP
23602568
种属内
DYRK1B Q9Y463 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
种属内
DYRK1B Q9Y463 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
DYRK1B Q9Y463 DCAF7 Homo sapiens P61962
TAP
23602568
种属内
DYRK1B Q9Y463 DCAF7 Homo sapiens P61962
Pull Down
32707033
种属内
DYRK1B Q9Y463 RB1 Homo sapiens P06400
Pull Down
32707033
种属内
DYRK1B Q9Y463 RB1 Homo sapiens P06400
Anti Tag CoIP
23602568
种属内
DYRK1B Q9Y463 RB1 Homo sapiens P06400
TAP
23602568
种属内
DYRK1B Q9Y463 MAP2K3 Homo sapiens P46734
Anti Bait CoIP
11980910
种属内
DYRK1B Q9Y463 PCBD2 Homo sapiens Q9H0N5
Y2H
11980910
种属内
DYRK1B Q9Y463 PCBD2 Homo sapiens Q9H0N5
Anti Bait CoIP
11980910
种属内
DYRK1B Q9Y463 HNF1A Homo sapiens P20823
Pull Down
11980910
种属内
DYRK1B Q9Y463 HNF1A Homo sapiens P20823
Protein Kinase Assay
11980910
种属内
DYRK1B Q9Y463 RANBP9 Homo sapiens Q96S59
Anti Bait CoIP
14500717
种属内
DYRK1B Q9Y463 RANBP9 Homo sapiens Q96S59
Anti Tag CoIP
14500717
种属内
DYRK1B Q9Y463 RANBP9 Homo sapiens Q96S59
Y2H
14500717
种属内
DYRK1B Q9Y463 LZTS2 Homo sapiens Q9BRK4
Pull Down
32707033
种属内
DYRK1B Q9Y463 LZTS2 Homo sapiens Q9BRK4
Anti Tag CoIP
23602568
种属内
DYRK1B Q9Y463 LZTS2 Homo sapiens Q9BRK4
TAP
23602568
种属内
DYRK1B Q9Y463 RBL1 Homo sapiens P28749
Anti Tag CoIP
23602568
种属内
DYRK1B Q9Y463 RBL1 Homo sapiens P28749
TAP
23602568
种属内
DYRK1B Q9Y463 RBL1 Homo sapiens P28749
Pull Down
32707033
种属内
DYRK1B Q9Y463 RBL1 Homo sapiens P28749
BiFC
23602568
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Abdominal Obesity-Metabolic Syndrome 3

AOMS3

Central Obesity, Type 2 Diabetes, Hypertension, And Early-Onset Coronary Artery Disease

Obesity, Abdominal, Metabolic Syndrome, Type 3

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7

Mental Retardation, Autosomal Dominant 7

Autosomal Dominant Non-Syndromic Intellectual Disability 7

Dyrk1a Syndrome

Autosomal Dominant Intellectual Developmental Disorder 7

Autosomal Dominant Mental Retardation 7

Mental Retardation, Autosomal Dominant, Type 7

Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome

Abdominal Obesity Metabolic Syndrome

Metabolic Syndrome X

Aoms2

Aoms1

Liver Rhabdomyosarcoma

Rhabdomyosarcoma Of Liver

Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Rhabdomyosarcoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DYRK1B VGNC VGNC:61686
Bos taurus DYRK1B VGNC VGNC:28280
Macaca mulatta DYRK1B VGNC VGNC:72016
Canis familiaris DYRK1B VGNC VGNC:40156
Rattus norvegicus DYRK1B RGD RGD:1307223
Mus musculus DYRK1B MGD MGI:1330302