1. Gene
  2. CD33 - CD33 molecule Gene

CD33 - CD33 molecule Gene

中文名称:CD33 分子

种属: Homo sapiens

同用名: p67; SIGLEC3; SIGLEC-3

基因 ID: 945 | 基因类型: protein coding

关于 CD33

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,211,076-51,240,016 (from NCBI)

This gene has 7 transcripts (splice variants), 73 orthologues and 16 paralogues. Broad expression in spleen (RPKM 7.5), bone marrow (RPKM 6.6) and 19 other tissues.

功能概要

启用蛋白磷酸酶结合活性和唾液酸结合活性。参与多个过程,包括细胞因子产生的负调节;单核细胞活化的负调节;蛋白酪氨酸磷酸酶活性的正调节。位于多种细胞成分中,包括高尔基体;质膜的外侧;和过氧化物酶体。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein Phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine Phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

CD33 基因产物(3)

mRNA Protein Name
NM_001082618.2 NP_001076087.1 myeloid cell surface antigen CD33 isoform 2
NM_001177608.2 NP_001171079.1 myeloid cell surface antigen CD33 isoform 3 precursor
NM_001772.4 NP_001763.3 myeloid cell surface antigen CD33 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10206955 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
10556798 GOA
enables protein tyrosine phosphatase activator activity IMP
IMP: 通过突变表型推断
10556798 GOA
enables sialic acid binding IMP
IMP: 通过突变表型推断
7718872 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Fc-gamma receptor signaling pathway IDA
IDA: 通过直接分析推断
10556798 GOA
involved in cell-cell adhesion IMP
IMP: 通过突变表型推断
7718872 GOA
involved in immune response-inhibiting signal transduction IDA
IDA: 通过直接分析推断
10887109 GOA
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
15597323 GOA
involved in negative regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
15597323 GOA
involved in negative regulation of monocyte activation IDA
IDA: 通过直接分析推断
15597323 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
15597323 GOA
involved in positive regulation of protein secretion IMP
IMP: 通过突变表型推断
27044754 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
21278227 GOA
located in cell surface IDA
IDA: 通过直接分析推断
28747436 GOA
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
20660734 GOA
located in peroxisome IDA
IDA: 通过直接分析推断
28747436 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21278227 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD33 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (23 - 136)

ig

ig: Immunoglobulin domain (156 - 214)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

myeloid cell surface antigen CD33

CD33 antigen (gp67)

CD33 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD33 P20138 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
种属内
CD33 P20138 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
种属内
CD33 P20138 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
种属内
CD33 P20138 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
种属内
CD33 P20138 S100A9 Homo sapiens P06702
Affinity Chrom
24216507
种属内
CD33 P20138 S100A9 Homo sapiens P06702
IF
24216507
种属内
CD33 P20138 S100A9 Homo sapiens P06702
ELISA
24216507
种属内
CD33 P20138 S100A9 Homo sapiens P06702
Anti Bait CoIP
24216507
种属内
CD33 P20138 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
种属内
CD33 P20138 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
种属内
CD33 P20138 KRT35 Homo sapiens Q92764
Y2H Array
32296183
种属内
CD33 P20138 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
种属内
CD33 P20138 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
种属内
CD33 P20138 TMEM243 Homo sapiens Q9BU79
Y2H Array
32296183
种属内
CD33 P20138 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
种属内
CD33 P20138 TMBIM1 Homo sapiens Q969X1
Validated Y2H
32296183
种属内
CD33 P20138 PTPN11 Homo sapiens Q06124
Anti Bait CoIP
17947393
种属内
CD33 P20138 PTPN11 Homo sapiens Q06124
Pull Down
17947393
种属内
CD33 P20138 THSD7A Homo sapiens Q9UPZ6
Validated Y2H
32296183
种属内
CD33 P20138 CXCL9 Homo sapiens Q07325
Validated Y2H
32296183
种属内
CD33 P20138 EMD Homo sapiens P50402
Validated Y2H
32296183
种属内
CD33 P20138 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
种属内
CD33 P20138 PTPN6 Homo sapiens P29350
Pull Down
10206955
种属内
CD33 P20138 PTPN6 Homo sapiens P29350
Pull Down
17947393
种属内
CD33 P20138 PTPN6 Homo sapiens P29350
Anti Bait CoIP
17947393
种属内
CD33 P20138 PTPN6 Homo sapiens P29350
Anti Bait CoIP
24216507
种属内
CD33 P20138 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
种属内
CD33 P20138 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
种属内
CD33 P20138 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
种属内
CD33 P20138 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属内
CD33 P20138 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属内
CD33 P20138 KRT31 Homo sapiens Q15323
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD33 蛋白

关联疾病

疾病名称 别名
Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia

Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia

T-Cell Childhood Acute Lymphocytic Leukemia

Childhood T Lymphoblastic Leukemia/Lymphoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia

Acute Leukemia Of Ambiguous Lineage

Acute Undifferentiated Leukemia

Acute Leukemia Of Indeterminate Lineage

Hybrid Acute Leukemia

Mixed Lineage Acute Leukemia

All With Myeloid Markers

Aml With Lymphoid Markers

Acute Leukemia Of Undetermined Lineage

Bal

Biphenotypic Acute Leukemia

Undifferentiated Acute Leukemia

Mpal

Acute Myeloid Leukemia, Minimal Differentiation, Fab M0

Leukemia, Biphenotypic, Acute

Acute Basophilic Leukemia
Myeloid Sarcoma

Granulocytic Sarcoma

Chloroma

Extramedullary Myeloid Tumor

Sarcoma, Granulocytic

Sarcoma Granulocytic

Sarcoma, Myeloid

Myelosarcoma

Myeloid Sarcoma Disease

Myeloid Sarcoma Nos

Myeloid Sarcoma Without Mention Of Remission

Central Nervous System Leukemia

Leukemia Of The Cns

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease

Sinusoidal Obstruction Syndrome

Hepatic Venoocclusive Disease

Venoocclusive Disease

Hepatic Vein Thrombosis

Budd-Chiari Syndrome

Hepatic Vein Occlusion

Veno-Occlusive Disease Of The Liver

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis

Transient Myeloproliferative Syndrome

Transient Myeloproliferative Disease

Mst

Tam

Leukemia, Transient, Of Down Syndrome

Tmd

Leukemia, Transient

Transient Leukemia

Transient Leukemia Of Down Syndrome

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Malignant Giant Cell Tumor Of The Tendon Sheath

Giant Cell Tumour Of Tendon Sheath, Malignant

Malignant Giant Cell Neoplasm Of The Tendon Sheath

Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia

Paediatric Acute Myeloid Leukaemia

Pediatric Acute Myeloid Leukemia

B-Cell Adult Acute Lymphocytic Leukemia

Adult B Acute Lymphoblastic Leukemia

Adult B Acute Lymphoblastic Leukaemia

Adult B-Cell Acute Lymphoblastic Leukaemia

Adult B-Cell Acute Lymphoblastic Leukemia

Adult B-Cell Lymphocytic Leukaemia

Adult B-Cell Lymphocytic Leukemia

Adult B-Lymphoblastic Leukaemia

Adult B-Lymphoblastic Leukemia

B-Cell Adult Acute Lymphocytic Leukaemia

B-Cell Adult Acute Lymphoblastic Leukemia

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma

B-All

Precursor B Lymphoblastic Lymphoma/Leukemia

C-All

Lymphoblastic Lymphoma, Nos

Common Precursor B All

Lymphoblastic B-Cell Lymphoma

Pro-B All

B-Precursor Lymphoma

Lbl - [Lymphoblastic Lymphoma]

Hepatic Vascular Disease

Vascular Disorder Of Liver

Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All

Chronic Leukemia

Adult Chronic Leukemia

Cll

Cml

Childhood Leukemia
Acute Myeloid Leukemia With Bcr-Abl1

Acute Myeleoid Leukemia With Bcr-Abl1

Leukemia, Acute Monocytic

Acute Monocytic Leukemia

Acute Monoblastic Leukemia And Acute Monocytic Leukemia

Acute Monocytic Leukaemia

Acute Monocytic Leukaemia Without Mention Of Remission

Acute Monocytic Leukemia Without Mention Of Remission

Acute Monocytic Leukemia, Fab M5

Acute Monocytic Leukemia, Morphology

Leukemia, Monocytic, Acute

M5b Acute Differentiated Monocytic Leukemia

Bone Marrow Cancer

Malignant Neoplasm Of Bone Marrow

Bone Marrow Neoplasm

Bone Marrow Tumor

Malignant Bone Marrow Tumor

Myeloproliferative Disorders

Bone Marrow Neoplasms

Myeloproliferative Disease

Chronic Myeloproliferative Disorder

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

Pancytopenia
Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic

Cmml

Leukemia Myelomonocytic Chronic

Cmml - [Chronic Myelomonocytic Leukaemia]

Chronic Myelomonocytic Leukaemia Without Mention Of Remission

Chronic Monocytic Leukaemia

Chronic Monocytoid Leukaemia

Bronchiectasis 1
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction

Left Ventricular Noncompaction 3

Dilated Cardiomyopathy 1c

CMD1C

Cardiomyopathy, Hypertrophic, 24

Dilated Cardiomyopathy With Left Ventricular Noncompaction

Cardiomyopathy, Dilated, 1c, With Or Without Lvnc

Cmdc1

Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction

Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction

Cardiomyopathy Dilated With Left Ventricular Noncompaction

Cardiomyopathy, Familial Hypertrophic 24

CMH24

Left Ventricular Non-Compaction 3

LVNC3

Cardiomyopathy, Dilated 1c

Familial Hypertrophic Cardiomyopathy 24

Cardiomyopathy, Dilated, 1c

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CD33 MGD MGI:99440
Rattus norvegicus CD33 RGD RGD:1596020
Macaca mulatta CD33 VGNC VGNC:81368
Macaca fascicularis CD33 NCBI NCBI:102117580
Others CD33 NCBI