2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection Autophagy Apoptosis Cell Cycle/DNA Damage PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK
  3. TRP Channel HPV Autophagy Apoptosis PERK Akt Src
  4. Larixyl acetate

Larixyl acetate 是一种有效的、选择性的 TRPC6 抑制剂，对 hTRPC6-YFP 和 hTRPC3-YFP 的 IC50 分别为 0.58 μM 和 6.83 μM。Larixyl acetate 预防 HPV，对创伤性脑损伤引起的全身内皮功能障碍有效。

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Larixyl acetate Chemical Structure

Larixyl acetate Chemical Structure

CAS No. : 4608-49-5

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规格 价格 是否有货 数量
1 mg ￥213
In-stock
5 mg ￥498
In-stock
10 mg ￥810
In-stock
25 mg ￥1463
In-stock
50 mg ￥2488
In-stock
100 mg ￥3563
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Larixyl acetate:

Larixyl acetate 相关抗体

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Larixyl acetate is a potent and selective TRPC6 inhibitor with IC50 values of 0.58 μM and 6.83 μM against hTRPC6-YFP and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction[1][2][3][4][5].

IC50 & Target

hTRPC6

0.58 μM (IC50)

hTRPC3

6.83 μM (IC50)

体外研究
(In Vitro)

Larixyl acetate (1-10 μM，3 分钟) 通过抑制 ERK1/2、AKT、Src 的磷酸化，抑制 fMLP 诱导的中性粒细胞迁移以及抑制 βγ 亚基与 Src 或 PLCβ 结合，来发挥抗炎活性[2]。
Larixyl acetate (5 μM，1小时) 通过抑制 TRPC6 活性，可有效改善 TBI 诱导的主动脉内皮功能障碍[3]。
Larixyl acetate（5 μM，72小时）在心脏肥大细胞模型中 (H9c2 大鼠心肌细胞，由 Ang II 诱导) 显著降低 ER 应激基因的表达，并改善其细胞功能[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Larixyl acetate 相关抗体:

Western Blot Analysis[2]

Cell Line: Human neutrophils
Concentration: 1, 2, 5, 10 μM
Incubation Time: 3 min
Result: Significantly inhibited fMLP-induced phosphorylation of ERK1/2, AKT, and Src.

Real Time qPCR[5]

Cell Line: H9c2 rat cardiomyocytes (cardiac hypertrophy model induced by Ang II (HY-13948))
Concentration: 5 μM
Incubation Time: 72 hours
Result: Significantly reduced the mRNA expression of cardiac hypertrophy-related genes (e.g., ANP, BNP, Myh7).
Significantly reduced the expression of ER stress-related genes GRP78, pPERK, ATF4, and CHOP.
体内研究
(In Vivo)

Larixyl acetate (5 mg/kg，腹腔注射，每日一次，持续 7 天) 通过抑制 TRPC6 活性，显著改善创伤性脑损伤 (TBI) 小鼠的主动脉内皮功能，特别是在增强乙酰胆碱诱导的舒张作用方面[3]。
Larixyl acetate (5 mg/kg，腹腔注射，每日一次，持续 4 周) 通过抑制 TRPC6，改善压力过载引起的心力衰竭模型中的心脏功能，减少心脏肥大、纤维化和细胞凋亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Closed-head mild traumatic brain injury (mTBI) model, C57BL/6, 129S, 129S-C57BL/6-F2 mice, TRPC6 knockout mice[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 7 days
Result: Significantly improved aortic endothelial function 7 days after TBI.
Caused that acetylcholine (10 μM) induced dilation was significantly enhanced in Larixyl acetate-treated mice (In C57BL/6 mice, the Larixyl acetate group showed 96.9 %; in 129S-C57BL/6-F2 mice, the Larixyl acetate group showed 89.2 %).
Animal Model: Transverse aortic constriction (Tac) model for pressure overload-induced heart failure in mice[5]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 4 weeks
Result: Significantly reduced cardiac hypertrophy, left ventricular pressure, and improved cardiac function (FS and EF increased).
Improved TAC-induced cardiac fibrosis, cardiomyocyte apoptosis, and inhibited ER stress-related proteins (e.g., GRP78) expression.
分子量

348.52

Formula

C22H36O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (286.93 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8693 mL 14.3464 mL 28.6928 mL
5 mM 0.5739 mL 2.8693 mL 5.7386 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.46%

COA (194 KB) HNMR (270 KB) LCMS (97 KB)

产品使用指南 (1538 KB)
参考文献

Larixyl acetate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8693 mL 14.3464 mL 28.6928 mL 71.7319 mL
5 mM 0.5739 mL 2.8693 mL 5.7386 mL 14.3464 mL
10 mM 0.2869 mL 1.4346 mL 2.8693 mL 7.1732 mL
15 mM 0.1913 mL 0.9564 mL 1.9129 mL 4.7821 mL
20 mM 0.1435 mL 0.7173 mL 1.4346 mL 3.5866 mL
25 mM 0.1148 mL 0.5739 mL 1.1477 mL 2.8693 mL
30 mM 0.0956 mL 0.4782 mL 0.9564 mL 2.3911 mL
40 mM 0.0717 mL 0.3587 mL 0.7173 mL 1.7933 mL
50 mM 0.0574 mL 0.2869 mL 0.5739 mL 1.4346 mL
60 mM 0.0478 mL 0.2391 mL 0.4782 mL 1.1955 mL
80 mM 0.0359 mL 0.1793 mL 0.3587 mL 0.8966 mL
100 mM 0.0287 mL 0.1435 mL 0.2869 mL 0.7173 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Larixyl4608-49-5TRP ChannelHPVAutophagyApoptosisPERKAktSrcTransient receptor potential channelsHuman papillomavirusProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePKBProtein kinase BHEK 293systemic endothelial dysfunctionInhibitorinhibitorinhibit

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