2. Apoptosis MAPK/ERK Pathway
  3. Apoptosis MEK
  4. MEK-IN-5

MEK-IN-5 是一种有效的 MEK 抑制剂和 NO 供体。MEK-IN-5 以剂量和时间依赖性方式显著降低 pMEK 和 pERK 的表达水平。MEK-IN-5 诱导 MDA-MB-231 细胞凋亡 (apoptosis)。

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MEK-IN-5 Chemical Structure

MEK-IN-5 Chemical Structure

CAS No. : 2417022-06-9

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MEK-IN-5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].

体外研究
(In Vitro)

MEK-IN-5 (compound 18h) shows anti-proliferation activities for different tumor cells and low toxicity for normal cells[1].
MEK-IN-5 (0.1, 1, 10 µM; 1, 2, 4, 6 h) decreases the expression level of pMEK and pERK in a dose-dependent and time-dependent manner[1].
MEK-IN-5 (1, 10 µM; 24 h) induces apoptosis in MDA-MB-231 cells[1].
MEK-IN-5 (100 µM; 2h) significantly induce NO release in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MEK-IN-5 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116, A549, Vero, HL7702 cells
Concentration:
Incubation Time:
Result: Showed anti-proliferation activities in MDA-MB-231, HCT116, A549, Vero, HL7702 cells with IC50s of 0.034, 0.64, 1.35, 21.07, 5.62 µM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 1, 10 µM
Incubation Time: 1, 2, 4, 6 h
Result: Decreased the expression level of pMEK and pERK in a dose-dependent and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1, 10 µM
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-231 cells.
分子量

674.67

Formula

C29H27FN4O10S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MEK-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEK-IN-52417022-06-9ApoptosisMEKMitogen-activated protein kinase kinaseMAPKKMAP2KAntitumorMDA-MB-231 cellspMEKpERKapoptosisNO releaseanti-proliferationHCT116 cellsInhibitorinhibitorinhibit

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