1. Anti-infection Apoptosis
  2. Fungal Apoptosis
  3. Moracin D

Moracin D 是一种黄酮类化合物,可以从桑树中提取出来。Moracin D 诱导细胞凋亡,具有降糖、抗脂肪、抗真菌和抗肿瘤作用。Moracin D 可用于真菌感染和乳腺癌研究。

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Moracin D Chemical Structure

Moracin D Chemical Structure

CAS No. : 69120-07-6

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Moracin D is a flavonoid that can be isolated from Morus alba. Moracin D induces cell apoptosis and shows hypoglycemic, antiadipogenic, antifungal and antitumor effects. Moracin D can be used for fungal infection and breast cancer research[1][2][3].

体外研究
(In Vitro)

Moracin D (0,3.75,7.5,15,30 μM;24 小时) 降低 DU145 和 PC3 细胞的活力,IC50 分别为 15 和 24.8 μM[1]
Moracin D (0,7.5,15 μM;24 小时) 增加 DU145 和 PC3 前列腺癌细胞的 sub G1 细胞群[1]
Moracin D (0,7.5,15 μM;24 小时) 抑制抗凋亡蛋白的表达水平,增加 DU145 细胞的 TUNEL 阳性细胞数,诱导 DU145 细胞凋亡[1]
Moracin D 对玫瑰镰刀菌、赤霉病菌、茄病菌、赤霉病菌、森氏刺头菌、黑蔷薇菌和麻斑病菌有抑菌活性,MIC 值分别为 7-14,28-56,112,7-14,56-112,<3.5 和 14-28 μg/mL[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: DU145 and PC3 cell lines
Concentration: 0, 3.75, 7.5, 15 and 30 μM
Incubation Time: 24 hours
Result: Significantly and dose-dependently reduced the viability of DU145 and PC3 cells.

Western Blot Analysis[1]

Cell Line: DU145 cell line
Concentration: 0, 7.5 and 15 μM
Incubation Time: 24 hours
Result: Cleaved PARP, activated PPAR-γ/PKC-δ, and decreased the level of Pro-caspase 3, Bcl-2, Bcl-xL, PKC-α and phosphorylation of NF-κB, ERK, AKT in DU145 cells.
分子量

308.33

Formula

C19H16O4

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Moracin D
目录号:
HY-122943
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