2. Apoptosis
  3. Apoptosis
  4. MPI-0441138

MPI-0441138 是凋亡 (apoptosis) 诱导剂和有丝分裂抑制剂。MPI-0441138 可诱导 DNA 断裂，诱导细胞色素 c 转位，导致肿瘤细胞死亡。

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MPI-0441138 Chemical Structure

MPI-0441138 Chemical Structure

CAS No. : 827030-33-1

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MPI-0441138 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
1.2 nM
Compound: 8
Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
HCT-116 GI50
0.002 μM
Compound: 2b, EPI28265
Growth inhibition of human HCT116 cells after 48 hrs by CellTiter-Glo assay
Growth inhibition of human HCT116 cells after 48 hrs by CellTiter-Glo assay
[PMID: 18651728]
HCT-116 EC50
0.002 μM
Compound: 6b, EP128265, MPI-0441138
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 19296653]
HCT-116 EC50
0.002 μM
Compound: 2b, EPI28265
Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs
Induction of apoptosis in human HCT116 cells assessed as caspase 3 activation after 24 hrs
[PMID: 18651728]
HeLa IC50
0.6 nM
Compound: 8
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
HeLa IC50
0.6 nM
Compound: 8
Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
MDA-MB-435 IC50
0.6 nM
Compound: 8
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SK-OV-3 IC50
0.8 nM
Compound: 8
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SK-OV-3 IC50
1.1 nM
Compound: 8
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SNU-398 EC50
0.002 μM
Compound: 6b, EP128265, MPI-0441138
Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 19296653]
T47D GI50
0.001 μM
Compound: 2b, EPI28265
Growth inhibition of human T47D cells after 48 hrs by CellTiter-Glo assay
Growth inhibition of human T47D cells after 48 hrs by CellTiter-Glo assay
[PMID: 18651728]
T47D EC50
0.002 μM
Compound: 6b, EP128265, MPI-0441138
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 19296653]
T47D EC50
0.002 μM
Compound: 2b, EPI28265
Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs
Induction of apoptosis in human T47D cells assessed as caspase 3 activation after 24 hrs
[PMID: 18651728]
U-251 IC50
32.5 nM
Compound: 8
Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
体外研究
(In Vitro)

MPI-0441138 (5 nM；72 h) 诱导 22Rv1、MDA-MB-231、Caco-2 和 Du145 细胞中的细胞凋亡和 DNA 片段化[1]。
MPI-0441138 (5 nM; 1 h) 诱导 AIF 和 细胞色素 c 从线粒体易位至细胞质和细胞核[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MPI-0441138 相关抗体:

Apoptosis Analysis[1]

Cell Line: 22Rv1, MDA-MB-231, Caco-2, and Du145 cells
Concentration: 5 nM
Incubation Time: 12, 24, 48, or 72 h
Result: Resulted robust caspase-3 activation and poly(ADP-ribose) polymerase cleavage, induced DNA fragmentation.
分子量

299.75

Formula

C16H14ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MPI-0441138 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPI-0441138827030-33-1MPI0441138MPI 0441138ApoptosisDNA breakagenuclear translocationanti-cancerInhibitorinhibitorinhibit

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目录号：
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