2. Epigenetics Anti-infection
  3. DNA Methyltransferase Parasite
  4. Nanaomycin A

Nanaomycin A 是第一个选择性 DNMT3B 抑制剂，IC50 为 500 nM。Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的抑癌基因。Nanaomycin A 抑制人疟原虫恶性疟原虫的体外生长，IC80 值为 33.1 nM。

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Nanaomycin A Chemical Structure

Nanaomycin A Chemical Structure

CAS No. : 52934-83-5

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Other Forms of Nanaomycin A:

Nanaomycin A 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

IC50 & Target[1]

DNMT3B

500 nM (IC50)

Plasmodium

 

体外研究
(In Vitro)

Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines[1].
Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells[1].
Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction[1].
Nanaomycin A not affects the enzymatic activity of DNMT1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nanaomycin A 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines
Concentration: 10, 100, 1000, 10000 nM
Incubation Time: 72 hours
Result: Had a distinct cytotoxic effect in all three cell lines.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5, 5 μM
Incubation Time: 72 hours
Result: Revealed induction of RASSF1A protein expression.

RT-PCR[1]

Cell Line: A549 cells
Concentration: 5 μM
Incubation Time: 72 hours
Result: Had an 18-fold relative induction.
分子量

302.28

Formula

C16H14O6
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.18%

COA (287 KB) HNMR (238 KB) RP-HPLC (532 KB) MS (334 KB)

产品使用指南 (1538 KB)
参考文献

Nanaomycin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nanaomycin A52934-83-5DNA MethyltransferaseParasiteDNMTsDNA MTasesDNMT3BantibioticssilencedtumorsuppressorgenesmalariaparasitePlasmodiumfalciparumInhibitorinhibitorinhibit

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