2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial HSV Antibiotic Endogenous Metabolite
  4. Oxytetracycline dihydrate

Oxytetracycline dihydrate  (Synonyms: 土霉素二水合物)

目录号: HY-B0275B 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

Oxytetracycline dihydrate 是一种属于四环素类的抗生素。Oxytetracycline dihydrate 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline dihydrate 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline dihydrate 还具有抗 HSV-1 的活性。

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Oxytetracycline dihydrate Chemical Structure

Oxytetracycline dihydrate Chemical Structure

CAS No. : 6153-64-6

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50 mg ￥400
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100 mg ￥550
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Customer Review

Other Forms of Oxytetracycline dihydrate:

Oxytetracycline dihydrate 相关抗体

Top Publications Citing Use of Products

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HSV-1 HSV-2 HSV

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity[1][2][3].

IC50 & Target[1][3]

Tetracycline

 

HSV-1

 

Bacterial

 

Microbial Metabolite

 

体外研究
(In Vitro)

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxytetracycline dihydrate 相关抗体:
体内研究
(In Vivo)

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1].
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

496.46

Formula

C22H28N2O11
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

土霉素二水合物；地霉素二水合物；氧四环素二水合物
结构分类
初始来源

Streptomyces rimosus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (100.71 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

1 M HCL 中的溶解度 : 10 mg/mL (20.14 mM; ultrasonic and adjust pH to 1 with 1 M HCL)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0143 mL 10.0713 mL 20.1426 mL
5 mM 0.4029 mL 2.0143 mL 4.0285 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

COA (202 KB)

产品使用指南 (1538 KB)
参考文献

Oxytetracycline dihydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
1 M HCL / DMSO 1 mM 2.0143 mL 10.0713 mL 20.1426 mL 50.3565 mL
5 mM 0.4029 mL 2.0143 mL 4.0285 mL 10.0713 mL
10 mM 0.2014 mL 1.0071 mL 2.0143 mL 5.0357 mL
15 mM 0.1343 mL 0.6714 mL 1.3428 mL 3.3571 mL
20 mM 0.1007 mL 0.5036 mL 1.0071 mL 2.5178 mL
DMSO 25 mM 0.0806 mL 0.4029 mL 0.8057 mL 2.0143 mL
30 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6786 mL
40 mM 0.0504 mL 0.2518 mL 0.5036 mL 1.2589 mL
50 mM 0.0403 mL 0.2014 mL 0.4029 mL 1.0071 mL
60 mM 0.0336 mL 0.1679 mL 0.3357 mL 0.8393 mL
80 mM 0.0252 mL 0.1259 mL 0.2518 mL 0.6295 mL
100 mM 0.0201 mL 0.1007 mL 0.2014 mL 0.5036 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxytetracycline dihydrate6153-64-6土霉素二水合物地霉素二水合物氧四环素二水合物BacterialHSVAntibioticEndogenous MetaboliteHerpes simplex virusproteinsynthesistetracyclineGram-negativeGram-positiveaminoacil-tRNAm-ribosomalHSV-1Inhibitorinhibitorinhibit

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