2. Epigenetics
  3. Epigenetic Reader Domain
  4. TAT-PiET-PROTAC

TAT-PiET-PROTAC 是经过蛋白水解靶向嵌合体 (PROTAC) 修饰的 TAT-PiET (HY-P10445)。TAT-PiET 是针对 BRD4 末端外 (ET) 结构域的细胞穿透肽，TAT-PiET-PROTAC 可破坏乳腺癌致癌基因 BRD4/JMJD6 相互作用，可抑制乳腺癌细胞生长。TAT-PiET-PROTAC 还抗 ERα 阳性乳腺癌细胞的内分泌耐药性，是乳腺癌的潜在抑制剂。

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Custom Peptide Synthesis

TAT-PiET-PROTAC Chemical Structure

TAT-PiET-PROTAC Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

TAT-PiET-PROTAC 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445). TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can disrupt the interaction between the breast cancer oncogene BRD4/JMJD6 and inhibit the growth of breast cancer cells. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells and is a potential inhibitor of breast cancer[1].

IC50 & Target

BRD4/JMJD6, BRD4 extraterminal (ET) domain[1]
分子量

3316.85

Formula

C145H239N53O35S
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Asn-Gln-Lys-Phe-Lys-Cys-Gly-Glu-{Ahx}-Tyl-{Hyp}-Tyr-Ile
Sequence Shortening

YGRKKRRQRRRRNQKFKCGE-{Ahx}-Y-{Hyp}-YI
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAT-PiET-PROTAC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-PiET-PROTACEpigenetic Reader DomainInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P10446
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