2. Apoptosis
  3. Apoptosis
  4. Telekin

Telekin 是一种从 Carpesium divaricatum 中分离出来的桉树型倍半萜内酯化合物。Telekin 可以激活线粒体介导的细胞凋亡 (apoptosis)，具有抗癌活性。

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Telekin Chemical Structure

Telekin Chemical Structure

CAS No. : 6752-90-5

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规格 价格 是否有货 数量
1 mg ￥2210
1 - 2 周
5 mg   询价  
10 mg   询价  

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Telekin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
4.27 μg/mL
Compound: 16
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by CCK8 assay
[PMID: 23451797]
HepG2 IC50
> 10 μM
Compound: 27
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32842729]
HepG2 IC50
8.14 μg/mL
Compound: 16
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by CCK8 assay
[PMID: 23451797]
HT-1080 IC50
3.5 μg/mL
Compound: 16
Antiproliferative activity against human HT1080 cells assessed as inhibition of cell proliferation after 72 hrs by CCK8 assay
Antiproliferative activity against human HT1080 cells assessed as inhibition of cell proliferation after 72 hrs by CCK8 assay
[PMID: 23451797]
Huh-7 IC50
> 10 μM
Compound: 27
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32842729]
MCF7 IC50
3 μg/mL
Compound: 13, eudesmanolide
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21109433]
SMMC-7721 IC50
> 10 μM
Compound: 27
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32842729]
分子量

248.32

Formula

C15H20O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telekin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telekin6752-90-5Apoptosissesquiterpene lactoneCarpesium divaricatumapoptosisanticancerHepG-2Inhibitorinhibitorinhibit

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目录号：
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