AKBA (Synonyms: Acetyl-11-keto-β-boswellic acid)

目录号: HY-N0892 纯度: 99.93%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

AKBA (Acetyl-11-keto-β-boswellic acid) 是一种从乳香中提取出的活性化合物，是新颖的 Nrf2 的活化剂。

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AKBA Chemical Structure

CAS No. : 67416-61-9

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥1466	In-stock
1 mg	￥594	In-stock
5 mg	￥1300	In-stock
10 mg	￥2300	In-stock
50 mg		询价
100 mg		询价

or 大包装询价

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Customer Review

Other Forms of AKBA:

AKBA (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•Int Immunopharmacol. 2023 Jun 24;121:110501. [Abstract]

AKBA 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

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HIF-1α HIF

生物活性
纯度 & 产品资料

生物活性

AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A253 cell line	IC₅₀	16.9 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human A253 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human A253 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
A2780	IC₅₀	14.1 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
A549	IC₅₀	3 μM Compound: 4	Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis	[PMID: 24844534]
DLD-1	IC₅₀	20.9 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human DLD1 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human DLD1 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
HCT-8	IC₅₀	17.5 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human HCT8 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human HCT8 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
HeLa	IC₅₀	31 μM Compound: 4, AKBA	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21334793]
HL-60	IC₅₀	11 μM Compound: 4, AKBA	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 21334793]
HT-29	IC₅₀	19.4 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
HUVEC	IC₅₀	7.45 μM Compound: 1, AKBA	Antiproliferation activity against HUVEC cells after 48 hrs by CCK-8 assay Antiproliferation activity against HUVEC cells after 48 hrs by CCK-8 assay	[PMID: 25819335]
LNCaP	GI₅₀	27.43 μM Compound: AKBA	Anti-proliferative activity against human LNCAP cells measured after 96 hrs by MTT assay Anti-proliferative activity against human LNCAP cells measured after 96 hrs by MTT assay	[PMID: 27997878]
PC-3	GI₅₀	31.86 μM Compound: AKBA	Anti-proliferative activity against human PC3 cells measured after 96 hrs by MTT assay Anti-proliferative activity against human PC3 cells measured after 96 hrs by MTT assay	[PMID: 27997878]
PC-3	GI₅₀	31.9 μM Compound: 1; AKBA	Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay	[PMID: 30153964]
RAW264.7	IC₅₀	15.6 μM Compound: AKBA	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs	[PMID: 23391590]
Sf21	IC₅₀	> 40 μM Compound: 29	Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	[PMID: 31774676]

体外研究
(In Vitro)

AKBA (Acetyl-11-keto-β-boswellic acid) 显著减少梗塞体积和凋亡细胞，并通过提高 48 小时大脑中动脉闭塞 (MCAO) 大鼠脑组织中 Nrf2 和 HO-1 的表达来增加神经系统评分再灌注后。在原代培养的神经元中，AKBA 增加了 Nrf2 和 HO-1 的表达，从而防止 OGD 诱导的氧化损伤。此外，AKBA 处理增加了 Nrf2 与抗氧化反应元件 (ARE) 的结合活性^[1]。
AKBA (乙酰基-11-酮基-β-乳香酸) 显著抑制人结肠腺癌的生长，表明细胞周期停滞在 G1 期并诱导细胞凋亡^[3]。
AKBA (乙酰基-11-酮基-β-乳香酸) 在 3T3-L1 中引发显著的脂肪分解脂肪细胞，如胞质溶胶中中性脂质减少和培养基中游离脂肪酸增加所示。AKBA 增加的脂肪分解伴随着脂肪分解酶、脂肪细胞甘油三酯脂肪酶 (ATGL) 和激素敏感性脂肪酶 (HSL) 的上调，以及脂滴稳定性调节因子 perilipin 的表达减少。此外，AKBA (Acetyl-11-keto-β-boswellic acid) 处理减少了成熟脂肪细胞中成熟脂肪细胞 aP2、脂联素和 glut-4 的表型标记^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

AKBA (Acetyl-11-keto-β-boswellic acid) 显著阻止了肠腺瘤性息肉的形成，对小鼠没有毒性。AKBA 在预防小肠和结肠息肉方面的活性比阿司匹林更有效。组织病理学检查显示 AKBA 的作用，即减少息肉大小和异型增生程度，在较大尺寸的息肉中更为突出，尤其是那些起源于结肠的息肉^[1]。
AKBA 在小鼠中给药有效地延迟了 HT-29 异种移植物的生长而没有毒性迹象。AKBA 的活性比阿司匹林强^[3]。
AKBA 在体外和体内均表现出抗癌活性。通过在小鼠中口服应用，AKBA 可显著抑制 SGC-7901 和 MKN-45 异种移植物，且无毒性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

512.72

Formula

C₃₂H₄₈O₅

CAS 号

67416-61-9

性状

固体

颜色

White to off-white

中文名称

3-乙酰基-11-酮基-β-乳香酸

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 5.2 mg/mL (10.14 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9504 mL	9.7519 mL	19.5038 mL
5 mM	0.3901 mL	1.9504 mL	3.9008 mL
10 mM	0.1950 mL	0.9752 mL	1.9504 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.93%

选择批次：

Data Sheet (612 KB) SDS (394 KB)

COA (196 KB) HNMR (292 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

AKBA 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9504 mL	9.7519 mL	19.5038 mL	48.7596 mL
	5 mM	0.3901 mL	1.9504 mL	3.9008 mL	9.7519 mL
	10 mM	0.1950 mL	0.9752 mL	1.9504 mL	4.8760 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKBA67416-61-9Acetyl-11-keto-β-boswellic acid3-乙酰基-11-酮基-β-乳香酸HIF/HIF Prolyl-HydroxylaseReactive Oxygen SpeciesEndogenous MetaboliteHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AKBA (Synonyms: Acetyl-11-keto-β-boswellic acid)

Customer Review

Other Forms of AKBA:

MCE 顾客使用本产品发表的 1 篇科研文献