Betulonic acid (Synonyms: 路路通酸; Betunolic acid; Liquidambaric acid; (+)-Betulonic acid)

目录号: HY-N1451 纯度: 98.06%: FAQs
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Betulonic acid (Betunolic acid) 是一种在许多植物中存在的三萜类化合物。Betulonic acid 具有抗肿瘤，抗炎，抗寄生虫和抗病毒 (HSV-1) 的活性。

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Betulonic acid Chemical Structure

CAS No. : 4481-62-3

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规格	价格	是否有货
1 mg	￥166	In-stock
5 mg	￥348	In-stock
10 mg	￥522	In-stock
25 mg	￥783	In-stock
50 mg	￥1174	In-stock
100 mg	￥1760	In-stock
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Other Forms of Betulonic acid:

Betulonic acid (Standard) 询价

MCE 顾客使用本产品发表的 2 篇科研文献

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生物活性
纯度 & 产品资料
参考文献

生物活性

Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities^[2]^[1]^[3]^[4].

IC₅₀ & Target

Plasmodium

HSV-1

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
518A2	IC₅₀	10.42 μM Compound: 2	Cytotoxicity against human 518A2 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
518A2	IC₅₀	12.93 μM Compound: 2	Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells assessed as cell viability after 96 hrs by SRB assay	[PMID: 23973824]
518A2	EC₅₀	29 μM Compound: 4	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 26547057]
8505C	IC₅₀	14 μM Compound: 2	Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay Cytotoxicity against human 8505C cells assessed as cell viability after 96 hrs by SRB assay	[PMID: 23973824]
A253 cell line	IC₅₀	10.05 μM Compound: 2	Cytotoxicity against human A253 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human A253 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
A2780	IC₅₀	2.98 μM Compound: 2	Cytotoxicity against human A2780 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human A2780 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
A2780	EC₅₀	20.4 μM Compound: 4	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 26547057]
A2780	EC₅₀	4.7 μM Compound: 2	Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32956968]
A2780	IC₅₀	5.97 μM Compound: 2	Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as cell viability after 96 hrs by SRB assay	[PMID: 23973824]
A-375	EC₅₀	14.3 μM Compound: 2	Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32956968]
A-375	IC₅₀	28.9 μM Compound: 1, BetA, Betulonic acid	Cytotoxicity against human A375 cells after 72 hrs by MTT assay Cytotoxicity against human A375 cells after 72 hrs by MTT assay	[PMID: 25874331]
A-431	IC₅₀	3.26 μM Compound: 2	Cytotoxicity against human A431 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human A431 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
A549	ED₅₀	> 10 μg/mL Compound: 13	Cytotoxic activity against human A549 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human A549 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
A549	IC₅₀	10.09 μM Compound: 2	Cytotoxicity against human A549 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human A549 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
A549	IC₅₀	10.42 μM Compound: 2	Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by SRB assay	[PMID: 23973824]
A549	IC₅₀	15 μM Compound: 1b	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 17371067]
A549	IC₅₀	15 μM Compound: 7, betulonic acid	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 15270560]
A549	EC₅₀	25.9 μM Compound: 4	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 26547057]
A549	IC₅₀	40 μM Compound: 5a	Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
A549	IC₅₀	5.7 μM Compound: 7	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 28500966]
A549	IC₅₀	8.93 μg/mL Compound: Betunolic acid	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 21106454]
Bcap37	IC₅₀	25.7 μM Compound: 1, BetA, Betulonic acid	Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay	[PMID: 25874331]
BJ	IC₅₀	39.5 μM Compound: 5a	Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay Cytotoxicity against human BJ cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
BRISTOL8	ED₅₀	2.6 μg/mL Compound: 13	Cytotoxic activity against human BRISTOL8 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human BRISTOL8 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
BV-2	IC₅₀	> 100 μM Compound: 28	Anti-neuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Anti-neuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 25466192]
BV-2	IC₅₀	60.7 μM Compound: 1	Anti-neuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 48 hrs by Griess reagent based assay Anti-neuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 48 hrs by Griess reagent based assay	[PMID: 34546050]
Ca9-22	IC₅₀	14.47 μg/mL Compound: Betunolic acid	Cytotoxicity against human Ca9-22 cells by MTT assay Cytotoxicity against human Ca9-22 cells by MTT assay	[PMID: 21106454]
CCRF-CEM	IC₅₀	14 μM Compound: 2a	Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay	[PMID: 27236068]
CCRF-CEM	IC₅₀	17 μM Compound: 7, betulonic acid	Cytotoxicity against human CEM cells after 72 hrs by MTT assay Cytotoxicity against human CEM cells after 72 hrs by MTT assay	[PMID: 15270560]
CCRF-CEM	IC₅₀	20 μM Compound: 3	Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay	[PMID: 22551630]
CCRF-CEM	IC₅₀	20 μM Compound: 1b	Cytotoxicity against human CEM cells after 72 hrs by MTT assay Cytotoxicity against human CEM cells after 72 hrs by MTT assay	[PMID: 17371067]
CCRF-CEM	ED₅₀	4.4 μg/mL Compound: 13	Cytotoxic activity against human CEM.CM3 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human CEM.CM3 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
CCRF-CEM	IC₅₀	8.4 μM Compound: 5a	Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
CHO	EC₅₀	4.71 μM Compound: 7	Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay	[PMID: 19911773]
COLO 205	IC₅₀	36.8 μM Compound: 17	Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay Cytotoxicity against human COLON205 cells after 48 hrs by MTT assay	[PMID: 17346076]
COS-1	EC₅₀	0 μM Compound: 7	Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay	[PMID: 19911773]
DU-145	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human DU145 cells by sulforhodamine B assay Antiproliferative activity in human DU145 cells by sulforhodamine B assay	[PMID: 29120172]
DU-145	CC₅₀	139 μM Compound: 9	Cytotoxic activity in human DU145 cells by sulforhodamine B assay Cytotoxic activity in human DU145 cells by sulforhodamine B assay	[PMID: 29120172]
DU-145	ED₅₀	3.1 μg/mL Compound: 13	Cytotoxic activity against human DU145 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human DU145 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
DU-145	IC₅₀	36 μM Compound: 7, betulonic acid	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 15270560]
FaDu	EC₅₀	17.4 μM Compound: 2	Cytotoxicity against human FaDu cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human FaDu cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32956968]
Fibroblast	CC₅₀	> 100 μM Compound: 2	Cytotoxicity against mock-infected human embryonic lung fibroblast cells incubated for 5 days by MTS assay Cytotoxicity against mock-infected human embryonic lung fibroblast cells incubated for 5 days by MTS assay	[PMID: 33877845]
H9	EC₅₀	0.22 μg/mL Compound: 4	Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral p24 antigen levels after 4 days by ELISA Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral p24 antigen levels after 4 days by ELISA	[PMID: 11678650]
HCT-116	IC₅₀	> 10 μM Compound: 7	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 28500966]
HCT-116	IC₅₀	2.61 μM Compound: 6	Antiproliferative activity against human HCT116 cells after 3 days by XTT assay Antiproliferative activity against human HCT116 cells after 3 days by XTT assay	[PMID: 19691293]
HCT-116	IC₅₀	38.1 μM Compound: 5a	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
HCT-116	IC₅₀	49.4 μM Compound: 5a	Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay Cytotoxicity against p53 knockout human HCT116 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
HEK293	CC₅₀	> 500 μM Compound: 9	Cytotoxic activity in HEK293 cells by sulforhodamine B assay Cytotoxic activity in HEK293 cells by sulforhodamine B assay	[PMID: 29120172]
HEK293	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in HEK293 cells by sulforhodamine B assay Antiproliferative activity in HEK293 cells by sulforhodamine B assay	[PMID: 29120172]
HeLa	CC₅₀	> 500 μM Compound: 9	Cytotoxic activity in human HeLa cells by sulforhodamine B assay Cytotoxic activity in human HeLa cells by sulforhodamine B assay	[PMID: 29120172]
HeLa	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human HeLa cells by sulforhodamine B assay Antiproliferative activity in human HeLa cells by sulforhodamine B assay	[PMID: 29120172]
Hep 3B2	IC₅₀	13.81 μg/mL Compound: Betunolic acid	Cytotoxicity against human Hep3B cells by MTT assay Cytotoxicity against human Hep3B cells by MTT assay	[PMID: 21106454]
HEp-2	CC₅₀	> 500 μM Compound: 9	Cytotoxic activity in human Hep2 cells by sulforhodamine B assay Cytotoxic activity in human Hep2 cells by sulforhodamine B assay	[PMID: 29120172]
HEp-2	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human Hep2 cells by sulforhodamine B assay Antiproliferative activity in human Hep2 cells by sulforhodamine B assay	[PMID: 29120172]
HepG2	CC₅₀	150.5 μM Compound: 4b	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 29326018]
HepG2	IC₅₀	4.32 μg/mL Compound: Betunolic acid	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 21106454]
HT-29	IC₅₀	10.02 μM Compound: 2	Cytotoxicity against human HT-29 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
HT-29	IC₅₀	17 μM Compound: 1b	Cytotoxicity against human HT29 cells after 72 hrs by MTT assay Cytotoxicity against human HT29 cells after 72 hrs by MTT assay	[PMID: 17371067]
HT-29	IC₅₀	17 μM Compound: 7, betulonic acid	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 15270560]
HT-29	EC₅₀	18.5 μM Compound: 2	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32956968]
Jurkat	ED₅₀	0.4 μg/mL Compound: 13	Cytotoxic activity against human JurkatE6.1 cell line was measured after 72 h using MTT assay Cytotoxic activity against human JurkatE6.1 cell line was measured after 72 h using MTT assay	[PMID: 15225732]
K562	IC₅₀	13.6 μM Compound: 5a	Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay Cytotoxicity against human K562 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
K562	IC₅₀	16.1 μM Compound: 17	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 17346076]
K562	IC₅₀	17 μM Compound: 7, betulonic acid	Cytotoxicity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay Cytotoxicity against paclitaxel-resistant human K562 cells after 72 hrs by MTT assay	[PMID: 15270560]
K562	IC₅₀	6 μM Compound: 1b	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 17371067]
K562	IC₅₀	6 μM Compound: 7, betulonic acid	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 15270560]
K562/Adr	IC₅₀	48.4 μM Compound: 17	Cytotoxicity against human doxorubicin-resistant K562/Adr cells in presence of 1 uM doxorubicin after 48 hrs by MTT assay Cytotoxicity against human doxorubicin-resistant K562/Adr cells in presence of 1 uM doxorubicin after 48 hrs by MTT assay	[PMID: 17346076]
K562/Adr	IC₅₀	73.5 μM Compound: 17	Cytotoxicity against human doxorubicin-resistant K562/Adr cells after 48 hrs by MTT assay Cytotoxicity against human doxorubicin-resistant K562/Adr cells after 48 hrs by MTT assay	[PMID: 17346076]
KB	CC₅₀	> 500 μM Compound: 9	Cytotoxic activity in human KB cells by sulforhodamine B assay Cytotoxic activity in human KB cells by sulforhodamine B assay	[PMID: 29120172]
KB	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human KB cells by sulforhodamine B assay Antiproliferative activity in human KB cells by sulforhodamine B assay	[PMID: 29120172]
KB	IC₅₀	3.8 μM Compound: 17	Cytotoxicity against human KB cells after 48 hrs by MTT assay Cytotoxicity against human KB cells after 48 hrs by MTT assay	[PMID: 17346076]
L132	ED₅₀	> 10 μg/mL Compound: 13	Cytotoxic activity against human L132 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human L132 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
MCF7	IC₅₀	> 10 μM Compound: 7	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 28500966]
MCF7	CC₅₀	> 500 μM Compound: 9	Cytotoxic activity in human MCF7 cells by sulforhodamine B assay Cytotoxic activity in human MCF7 cells by sulforhodamine B assay	[PMID: 29120172]
MCF7	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human MCF7 cells by sulforhodamine B assay Antiproliferative activity in human MCF7 cells by sulforhodamine B assay	[PMID: 29120172]
MCF7	IC₅₀	10.37 μM Compound: 2	Cytotoxicity against human MCF7 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
MCF7	IC₅₀	10.42 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell viability after 96 hrs by SRB assay	[PMID: 23973824]
MCF7	EC₅₀	12 μM Compound: 2	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32956968]
MCF7	IC₅₀	18.2 μM Compound: 1, BetA, Betulonic acid	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 25874331]
MCF7	IC₅₀	19.32 μg/mL Compound: Betunolic acid	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 21106454]
MCF7	EC₅₀	25.9 μM Compound: 4	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 26547057]
MCF7	IC₅₀	29 μM Compound: 7, betulonic acid	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 15270560]
MCF7	IC₅₀	49 μM Compound: 17	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 17346076]
MDA-MB-231	IC₅₀	> 20 μg/mL Compound: Betunolic acid	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 21106454]
MDA-MB-231	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human MDA-MB-231 cells by sulforhodamine B assay Antiproliferative activity in human MDA-MB-231 cells by sulforhodamine B assay	[PMID: 29120172]
MDA-MB-231	CC₅₀	60.9 μM Compound: 9	Cytotoxic activity in human MDA-MB-231 cells by sulforhodamine B assay Cytotoxic activity in human MDA-MB-231 cells by sulforhodamine B assay	[PMID: 29120172]
MDA-MB-231	IC₅₀	9.77 μM Compound: 6	Antiproliferative activity against human MDA-MB-231 cells after 3 days by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 3 days by MTT assay	[PMID: 19691293]
MGC-803	IC₅₀	17.7 μM Compound: 1, BetA, Betulonic acid	Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay	[PMID: 25874331]
MIA PaCa-2	IC₅₀	> 10 μM Compound: 7	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 28500966]
MOLT-4	ED₅₀	1.2 μg/mL Compound: 13	Cytotoxic activity against human MOLT-4 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human MOLT-4 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
MRC5	IC₅₀	29.5 μM Compound: 5a	Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay Cytotoxicity against human MRC5 cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
NIH3T3	EC₅₀	13.1 μM Compound: 4	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay	[PMID: 26547057]
NIH3T3	EC₅₀	19.4 μM Compound: 2	Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 32956968]
PA-1	ED₅₀	1.2 μg/mL Compound: 13	Cytotoxic activity against human PA-1 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human PA-1 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
PC-3	IC₅₀	> 10 μM Compound: 7	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 28500966]
PC-3	IC₅₀	13.9 μM Compound: 1, BetA, Betulonic acid	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 25874331]
PC-3	IC₅₀	15 μM Compound: 1b	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 17371067]
PC-3	IC₅₀	15 μM Compound: 7, betulonic acid	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 15270560]
Platelet	IC₅₀	> 50 μg/mL Compound: Betunolic acid	Antiaggregatory activity in human platelets assessed as inhibition of thrombin-induced platelet aggregation by aggregometry Antiaggregatory activity in human platelets assessed as inhibition of thrombin-induced platelet aggregation by aggregometry	[PMID: 21106454]
Platelet	IC₅₀	44.71 μg/mL Compound: Betunolic acid	Antiaggregatory activity in human platelets assessed as inhibition of collagen-induced platelet aggregation by aggregometry Antiaggregatory activity in human platelets assessed as inhibition of collagen-induced platelet aggregation by aggregometry	[PMID: 21106454]
SiHa	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in human SiHa cells by sulforhodamine B assay Antiproliferative activity in human SiHa cells by sulforhodamine B assay	[PMID: 29120172]
SiHa	CC₅₀	116.8 μM Compound: 9	Cytotoxic activity in human SiHa cells by sulforhodamine B assay Cytotoxic activity in human SiHa cells by sulforhodamine B assay	[PMID: 29120172]
SK-MEL-2	IC₅₀	26 μM Compound: 1b	Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay	[PMID: 17371067]
SK-MEL-2	IC₅₀	26 μM Compound: 7, betulonic acid	Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells after 72 hrs by MTT assay	[PMID: 15270560]
SW-1736	IC₅₀	3.05 μM Compound: 2	Cytotoxicity against human SW1736 cells after 96 hrs by SRB colorimetric assay Cytotoxicity against human SW1736 cells after 96 hrs by SRB colorimetric assay	[PMID: 20472329]
SW948	IC₅₀	19.17 μM Compound: 6	Antiproliferative activity against human SW948 cells after 3 days by XTT assay Antiproliferative activity against human SW948 cells after 3 days by XTT assay	[PMID: 19691293]
U2OS	IC₅₀	38 μM Compound: 5a	Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay Cytotoxicity against human U2OS cells incubated for 72 hrs by MTS assay	[PMID: 31677446]
U-87MG ATCC	IC₅₀	159 μM Compound: 1b	Cytotoxicity against human U87-Mg cells after 72 hrs by MTT assay Cytotoxicity against human U87-Mg cells after 72 hrs by MTT assay	[PMID: 17371067]
U-937	ED₅₀	2.8 μg/mL Compound: 13	Cytotoxic activity against human U937 cell line was measured after 72 hr using MTT assay Cytotoxic activity against human U937 cell line was measured after 72 hr using MTT assay	[PMID: 15225732]
Vero	CC₅₀	> 400 μM Compound: 4b	Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay	[PMID: 29326018]
Vero	CC₅₀	> 500 μM Compound: 9	Cytotoxic activity in African green monkey Vero cells by sulforhodamine B assay Cytotoxic activity in African green monkey Vero cells by sulforhodamine B assay	[PMID: 29120172]
Vero	IC₅₀	> 500 μM Compound: 9	Antiproliferative activity in African green monkey Vero cells by sulforhodamine B assay Antiproliferative activity in African green monkey Vero cells by sulforhodamine B assay	[PMID: 29120172]
Vero	EC₅₀	0.63 μM Compound: 14	Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA	[PMID: 17663539]
Vero	CC₅₀	112 μM Compound: 14	Cytotoxicity against Vero E6 cells by MTT assay Cytotoxicity against Vero E6 cells by MTT assay	[PMID: 17663539]
Vero	CC₅₀	35.6 μM Compound: Betulonic acid	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 2 days by trypan blue exclusion assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 2 days by trypan blue exclusion assay	[PMID: 26112446]

体外研究
(In Vitro)

BetμLonic acid (72 h)?抑制多种类型的人肿瘤细胞系的生长，包括?MGC-803、PC3、Bcap-37、A375、MCF-7?肿瘤细胞系，IC₅₀?为分别为?17.7、13.9、25.7、28.9、18.2 μM^[2]。
BetμLonic acid?具有抗疟原虫活性，IC₅₀?为?10 μM^[3]。
BetμLonic acid 抑制?HSV-1、ECHO6?和流感?FPV?病毒，EC₅₀分别为?0.9、73.32?和?5.7 μM^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

454.68

Formula

C₃₀H₄₆O₃

CAS 号

4481-62-3

性状

固体

颜色

White to off-white

中文名称

桦木酮酸；白桦脂酮酸；路路通酸

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 5 mg/mL (11.00 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1993 mL	10.9967 mL	21.9935 mL
5 mM	0.4399 mL	2.1993 mL	4.3987 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.67 mg/mL (1.47 mM); 澄清溶液

此方案可获得 ≥ 0.67 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 6.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% Corn Oil
Solubility: ≥ 0.67 mg/mL (1.47 mM); 澄清溶液

此方案可获得 ≥ 0.67 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。
以 1 mL 工作液为例，取 100 μL 6.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 98.06%

选择批次：

Data Sheet (632 KB) SDS (393 KB)

COA (292 KB) HNMR (296 KB) RP-HPLC (248 KB) MS (69 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Bastos DZL, et, al. Biotransformation of betulinic and betulonic acids by fungi. Phytochemistry. 2007 Mar;68(6):834-9. [Content Brief]

[2]. Yang SJ, et, al. Synthesis and biological evaluation of betulonic acid derivatives as antitumor agents. Eur J Med Chem. 2015;96:58-65. [Content Brief]

[3]. Sá MS, et, al. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol Res. 2009 Jul;105(1):275-9. [Content Brief]

[4]. Pavlova NI, et, al. Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia. 2003 Jul;74(5):489-92. [Content Brief]

Betulonic acid 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1993 mL	10.9967 mL	21.9935 mL	54.9837 mL
	5 mM	0.4399 mL	2.1993 mL	4.3987 mL	10.9967 mL
	10 mM	0.2199 mL	1.0997 mL	2.1993 mL	5.4984 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Betulonic acid (Synonyms: 路路通酸; Betunolic acid; Liquidambaric acid; (+)-Betulonic acid)

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Betulonic acid (Synonyms: 路路通酸; Betunolic acid; Liquidambaric acid; (+)-Betulonic acid)

Customer Review

Other Forms of Betulonic acid:

Betulonic acid 相关抗体

MCE 顾客使用本产品发表的 2 篇科研文献

Betulonic acid 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 Parasite 亚型特异性产品:

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生物活性

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参考文献

Betulonic acid 相关抗体:

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完整储备液配制表

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