2. Anti-infection
  3. Bacterial Antibiotic
  4. DuP 105

DuP 105 是一种可口服的恶唑烷酮类化合物，能够抗葛兰素阳性菌。

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DuP 105 Chemical Structure

DuP 105 Chemical Structure

CAS No. : 96800-41-8

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥17423
In-stock
5 mg   询价  
10 mg   询价  

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DuP 105 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria.

IC50 & Target

Oxazolidinone

 

体外研究
(In Vitro)

DuP 105 shows inhibitory activities against staphylococcal isolates and B. fragilis isolates with MIC90s of 4 to 16 μg/mL and 16 μg/mL[1]. DuP 105 MICs for 50% of the 216 gram-positive isolates tested (MIC50s) range from 4.0 to 16 μg/mL[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DuP 105 相关抗体:
体内研究
(In Vivo)

DuP 105 administered by either the oral or the parenteral route is protective against staphylococcal and streptococcal infections in mice with the 50% effective doses of 9 to 23 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

296.34

Formula

C13H16N2O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (421.81 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3745 mL 16.8725 mL 33.7450 mL
5 mM 0.6749 mL 3.3745 mL 6.7490 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

The mice are made neutropenic by the intraperitoneal administration of 100 mg of cyclophosphamide per kg on days -5, -3, and 0 (the day of infection). The extent of immunosuppression is assessed by using a standard hematological technique to determine leukocyte counts. In all experiments, the leukocyte count in the cyclophosphamide-treated mice is less than 15% of that in nontreated mice from day 0 through day 7. On day 0, the mice are injected intraperitoneally with a bacterial inoculum suspended in 0.2 mL of saline containing 5% gastric porcine mucin. This inoculum (2×104 CFU) is fivefold that required to kill all the nontreated immunosuppressed mice in 48 h. Graded doses of the test compounds are administered by the subcutaneous or oral route at 1 and 4 h after infection. In parallel with the immunosuppressed mice, groups of nonimmunosuppressed mice are infected, and treated with the antibacterial drugs. The number of survivors on day 7 in each group is used to calculate the ED50 values of the test compounds.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

DuP 105 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3745 mL 16.8725 mL 33.7450 mL 84.3626 mL
5 mM 0.6749 mL 3.3745 mL 6.7490 mL 16.8725 mL
10 mM 0.3375 mL 1.6873 mL 3.3745 mL 8.4363 mL
15 mM 0.2250 mL 1.1248 mL 2.2497 mL 5.6242 mL
20 mM 0.1687 mL 0.8436 mL 1.6873 mL 4.2181 mL
25 mM 0.1350 mL 0.6749 mL 1.3498 mL 3.3745 mL
30 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8121 mL
40 mM 0.0844 mL 0.4218 mL 0.8436 mL 2.1091 mL
50 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.6873 mL
60 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4060 mL
80 mM 0.0422 mL 0.2109 mL 0.4218 mL 1.0545 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.8436 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DuP 10596800-41-8DuP105DuP-105BacterialAntibioticInhibitorinhibitorinhibit

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目录号：
HY-101726
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