2. Metabolic Enzyme/Protease Autophagy Anti-infection
  3. HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease
  4. Oroxylin A

Oroxylin A  (Synonyms: 千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein)

目录号: HY-N0560 纯度: 99.74%
COA 产品使用指南

摩尔计算器

千层纸素 (Oroxylin A) 是一种有活性的黄酮类化合物，具有较强的抗癌作用。Oroxylin A 可抑制 IL-6/STAT3 通路和 NF-κB 信号传导，抑制细胞增殖并诱导细胞凋亡 (apoptosis)。Oroxylin A 可抑制结肠炎相关的癌发生。

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Oroxylin A Chemical Structure

Oroxylin A Chemical Structure

CAS No. : 480-11-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥524
In-stock
5 mg ￥477
In-stock
10 mg ￥716
In-stock
25 mg ￥1290
In-stock
50 mg ￥1800
In-stock
100 mg ￥2520
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Oroxylin A:

Oroxylin A 相关抗体

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
33.9 μM
Compound: 1, Oroxylin A
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 22196122]
HepG2 IC50
22.7 μM
Compound: 1, Oroxylin A
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 22196122]
HUVEC IC50
61 μM
Compound: 5
Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA
Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA
[PMID: 9214730]
KB IC50
16.1 μM
Compound: O, oroxylin-A
Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days
Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days
[PMID: 18722769]
KB IC50
31.1 μM
Compound: O, oroxylin-A
Cytotoxicity against human KB cells after 3 days
Cytotoxicity against human KB cells after 3 days
[PMID: 18722769]
MV4-11 GI50
5.59 μM
Compound: 14, Oroxylin
Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
[PMID: 23411073]
RS4-11 GI50
40 μM
Compound: 14, Oroxylin
Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
[PMID: 23411073]
体外研究
(In Vitro)

Oroxylin A (20 μM; 24 h) 抑制 MDA-MB-231 细胞的生长、增殖、迁徙。Oroxylin A 还抑制 MDA-MB-231 的侵袭，抑制其上皮-间质转化 (EMT) 过程[4]。
Oroxylin A (20 μM; 24 h) 还抑制促炎细胞因子表达，抑制 NF-κB 信号通路[4]。
Oroxylin A 的抗炎作用会被 TNF-α 消弭[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oroxylin A 相关抗体:
分子量

284.26

Formula

C16H12O5
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

千层纸素A
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 32 mg/mL (112.57 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.87%

COA (195 KB) LCMS (265 KB)

产品使用指南 (1538 KB)
参考文献

Oroxylin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5179 mL 17.5895 mL 35.1791 mL 87.9477 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL 17.5895 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
15 mM 0.2345 mL 1.1726 mL 2.3453 mL 5.8632 mL
20 mM 0.1759 mL 0.8795 mL 1.7590 mL 4.3974 mL
25 mM 0.1407 mL 0.7036 mL 1.4072 mL 3.5179 mL
30 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9316 mL
40 mM 0.0879 mL 0.4397 mL 0.8795 mL 2.1987 mL
50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7590 mL
60 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
80 mM 0.0440 mL 0.2199 mL 0.4397 mL 1.0993 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8795 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oroxylin A480-11-5Baicalein 6-methyl ether 6-Methoxybaicalein千层纸素AHIF/HIF Prolyl-HydroxylaseAutophagyVirus ProteaseHypoxia-inducible factorsHIFsHIF-PHcolitis-associated cancerchemopreventioninflammationIL-6/STAT3 pathwayInhibitorinhibitorinhibit

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