2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. Alteminostat

Alteminostat  (Synonyms: CKD-581)

目录号: HY-109109 纯度: 98.66%
COA 产品使用指南

摩尔计算器

Alteminostat (CKD-581) 是一种有效的 HDAC 抑制剂。Alteminostat 通过组蛋白 H3 和微管蛋白乙酰化抑制 I-II 类 HDAC 家族。Alteminostat 可用于淋巴瘤和多发性骨髓瘤的研究。

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Alteminostat Chemical Structure

Alteminostat Chemical Structure

CAS No. : 1246374-97-9

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1 mg ￥2045
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5 mg ￥4500
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Customer Review

Alteminostat 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Alteminostat (CKD-581) is a potent HDAC inhibitor. Alteminostat inhibits the class I-II HDAC family via histone H3 and tubulin acetylation. Alteminostat can be used for lymphoma and multiple myeloma research[1].

体外研究
(In Vitro)

Alteminostat (CKD-581; 1 nM-10 μM; 72 hours) treatment potently reduces cell viability in all four lymphoma cell lines in a concentration-dependent manner. The IC50 values of Alteminostat in SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells are 1.31 nM, 36.91 nM, 1.18 nM, and 31.99 nM, respectively[1].
Alteminostat (CKD-581; 10-300 nM; 24 hours) treatment decreases the expression of BCL-6 as well as BCL-2 in cells[1].
Alteminostat (CKD-581; 30-300 nM; 24 h) treatment results in γH2AX accumulation and PARP1 cleavage in SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells. Alteminostat decreases the protein levels of BCL-XL and MCL-1 in a concentration-dependent manner in OCI-LY1 cells[1].
Alteminostat (CKD-581; 10-300 nM; 6 hours) treatment increases the acetylation of histone H3 in SU-DHL-2 cells. And tubulin acetylation also increased with 10 nM CKD-581. CKD-581 increased the acetylation of target molecules by inhibiting class I-II HDACs in lymphoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Alteminostat 相关抗体:

Cell Viability Assay[1]

Cell Line: SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells
Concentration: 1 nM-10 μM
Incubation Time: 72 hours
Result: Potently reduced cell viability in all four lymphoma cell lines in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: SU-DHL-4 and OCI-LY1 cells
Concentration: 10 nM, 30 nM, 100 nM, 300 nM
Incubation Time: 24 hours
Result: Decreased the expression of BCL-6 as well as BCL-2 in cells.
体内研究
(In Vivo)

Alteminostat (CKD-581; 20-40 mg/kg; ntraperitoneal injection; twice a week; for 4 weeks) treatment partially but significantly suppresses tumor growth in SU-DHL-4 xenograft mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NOD.CB17 SCID injected with SU-DHL-4 cells[1]
Dosage: 20 mg/kg or 40 mg/kg
Administration: Intraperitoneal injection; twice a week; for 4 weeks
Result: Partially but significantly suppressed tumor growth.
Clinical Trial
分子量

492.61

Formula

C27H36N6O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 230 mg/mL (466.90 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0300 mL 10.1500 mL 20.3000 mL
5 mM 0.4060 mL 2.0300 mL 4.0600 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Alteminostat 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0300 mL 10.1500 mL 20.3000 mL 50.7501 mL
5 mM 0.4060 mL 2.0300 mL 4.0600 mL 10.1500 mL
10 mM 0.2030 mL 1.0150 mL 2.0300 mL 5.0750 mL
15 mM 0.1353 mL 0.6767 mL 1.3533 mL 3.3833 mL
20 mM 0.1015 mL 0.5075 mL 1.0150 mL 2.5375 mL
25 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0300 mL
30 mM 0.0677 mL 0.3383 mL 0.6767 mL 1.6917 mL
40 mM 0.0508 mL 0.2538 mL 0.5075 mL 1.2688 mL
50 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0150 mL
60 mM 0.0338 mL 0.1692 mL 0.3383 mL 0.8458 mL
80 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6344 mL
100 mM 0.0203 mL 0.1015 mL 0.2030 mL 0.5075 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alteminostat1246374-97-9CKD-581CKD581CKD 581HDACApoptosisHistone deacetylasesLymphomamyelomaanticancerγH2AXacetylationPARP1apoptosisBCL-2BCL-6BCL-XLInhibitorinhibitorinhibit

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