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  4. Anti-infective agent 4

Anti-infective agent 4 (compound 73) 是一种具有口服活性的 Trypanosoma cruzi 抑制剂，IC50 值为 0.016 μM。Anti-infective agent 4 可有效减少体内寄生虫负担。Anti-infective agent 4 可用于感染的研究。

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Anti-infective agent 4 Chemical Structure

Anti-infective agent 4 Chemical Structure

CAS No. : 2738381-52-5

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Anti-infective agent 4 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection[1].

IC50 & Target

Trypanosoma

 

体外研究
(In Vitro)

Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.016 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-infective agent 4 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: 3T3 cells
Concentration: 0.1 nM-100 μM
Incubation Time: 48 hours
Result: Showed activity against 3T3 cells with an CC50 value of ＞37 μM.
体内研究
(In Vivo)

Anti-infective agent 4 (50 mg/kg; p.o. once daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1]
Dosage: 50 mg/kg
Administration: Oral gavage; 50 mg/kg once daily for five days
Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.
分子量

431.32

Formula

C19H12F3N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-infective agent 4 相关分类

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-infective agent 42738381-52-5Parasitenitroimidazopyrazinoneoralanti-infective3T3parasitemiceInhibitorinhibitorinhibit

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目录号：
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