2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Disulfamide

Disulfamide，一种具有口服活性的利尿剂，碳酸酐酶 (carbonic anhydrase) 抑制剂，其 IC50 值为 0.07 μM。Disulfamide 可通过抑制碳酸酐酶，阻止钠、碳酸氢盐在近曲小管中的重吸收，从而导致利尿。

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Disulfamide Chemical Structure

Disulfamide Chemical Structure

CAS No. : 671-88-5

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Disulfamide 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

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CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule[1].

IC50 & Target

IC50: 0.07 μM (carbonic anhydrase)[1]
体内研究
(In Vivo)

Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing between 200-300 g[2]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; once
Result: Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%.
分子量

284.74

Formula

C7H9ClN2O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Disulfamide 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disulfamide671-88-5Carbonic AnhydraseCarbonate dehydratasecarbonic anhydrasediuretic,Inhibitorinhibitorinhibit

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产品名称：
Disulfamide
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HY-137364
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