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  3. Reactive Oxygen Species Virus Protease
  4. (E)-3,4-Dimethoxycinnamic acid

(E)-3,4-Dimethoxycinnamic acid  (Synonyms: (E)-3,4-二甲氧基肉桂酸; (E)-O-Methylferulic acid)

目录号: HY-N1778A 纯度: 99.91%
COA 产品使用指南

摩尔计算器

(E)-3,4-Dimethoxycinnamic acid 是 3,4-Dimethoxycinnamic acid 的低活性异构体。3,4-Dimethoxycinnamic acid 通过 ROS 介导的信号途径对 L-02 细胞发挥抗凋亡作用。

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(E)-3,4-Dimethoxycinnamic acid Chemical Structure

(E)-3,4-Dimethoxycinnamic acid Chemical Structure

CAS No. : 14737-89-4

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥440
In-stock
500 mg ￥400
In-stock
1 g ￥550
In-stock
5 g ￥900
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Customer Review

Other Forms of (E)-3,4-Dimethoxycinnamic acid:

(E)-3,4-Dimethoxycinnamic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 EC50
> 480 μM
Compound: 11
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 12027739]
B16-BL6 EC50
> 480 μM
Compound: 11
Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay
Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 12027739]
BALB/3T3 IC50
> 480.3 μM
Compound: 13
Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
[PMID: 10096863]
HeLa EC50
> 480 μM
Compound: 11
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 12027739]
HepG2 2.2.15 IC50
> 600 μM
Compound: 2a
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBsAg secretion by ELISA
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBsAg secretion by ELISA
[PMID: 25847765]
HepG2 2.2.15 IC50
> 600 μM
Compound: 2a
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBeAg secretion by ELISA
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBeAg secretion by ELISA
[PMID: 25847765]
HepG2 2.2.15 CC50
534.66 μM
Compound: 2a
Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTT assay
[PMID: 25847765]
HT-1080 EC50
> 480 μM
Compound: 11
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 12027739]
Oocyte IC50
206 μM
Compound: 3,4-diO-Me-Caf-COOH
Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
[PMID: 23682762]
U-937 IC50
> 2000 μM
Compound: 21
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
[PMID: 22925447]
U-937 CC50
> 2000 μM
Compound: 21
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
[PMID: 22925447]
体外研究
(In Vitro)

3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 μM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1].
3,4-Dimethoxycinnamic acid (25, 50 and 100 μM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1].
3,4-Dimethoxycinnamic acid (25, 50 and 100 μM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1].
3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-3,4-Dimethoxycinnamic acid 相关抗体:
分子量

208.21

Formula

C11H12O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

(E)-3-(3,4-二甲氧基苯基)丙烯酸；(E)-3,4-二甲氧基肉桂酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (240.14 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.01 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.01 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料

纯度: 99.91%

COA (285 KB) HNMR (112 KB) RP-HPLC (193 KB)

产品使用指南 (1538 KB)
参考文献

(E)-3,4-Dimethoxycinnamic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8028 mL 24.0142 mL 48.0284 mL 120.0711 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL 24.0142 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL 12.0071 mL
15 mM 0.3202 mL 1.6009 mL 3.2019 mL 8.0047 mL
20 mM 0.2401 mL 1.2007 mL 2.4014 mL 6.0036 mL
25 mM 0.1921 mL 0.9606 mL 1.9211 mL 4.8028 mL
30 mM 0.1601 mL 0.8005 mL 1.6009 mL 4.0024 mL
40 mM 0.1201 mL 0.6004 mL 1.2007 mL 3.0018 mL
50 mM 0.0961 mL 0.4803 mL 0.9606 mL 2.4014 mL
60 mM 0.0800 mL 0.4002 mL 0.8005 mL 2.0012 mL
80 mM 0.0600 mL 0.3002 mL 0.6004 mL 1.5009 mL
100 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2007 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-3,4-Dimethoxycinnamic acid14737-89-4(E)-O-Methylferulic acid(E)-3-(3,4-二甲氧基苯基)丙烯酸(E)-3,4-二甲氧基肉桂酸Reactive Oxygen SpeciesVirus ProteaseInhibitorinhibitorinhibit

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