2. Gene
  3. Cd14 - CD14 antigen Gene

Cd14 - CD14 antigen Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 12475 | 基因类型: protein coding

关于 Cd14

功能概要

This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and Fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]

Cd14 基因产物(1)

mRNA Protein Name
NM_009841.4 NP_033971.1 monocyte differentiation antigen CD14 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
8612135 MGI
involved in positive regulation of endocytosis IMP
IMP: 通过突变表型推断
22078883 MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: 通过突变表型推断
24380872 MGI
involved in positive regulation of toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
24380872 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
8612135 MGI
involved in positive regulation of type I interferon production IMP
IMP: 通过突变表型推断
22078883 MGI
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
24380872 MGI
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
22078883 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
involved in response to bacterium IMP
IMP: 通过突变表型推断
8612135 MGI
involved in response to molecule of bacterial origin IDA
IDA: 通过直接分析推断
15493995 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8612135 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
15493995 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

monocyte differentiation antigen CD14

myeloid cell-specific leucine-rich glycoprotein

重组 Cd14 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73531 CD14 Protein, Mouse (HEK293, His) P10810/NP_033971.1 (S16-P345) ≥95%
HY-P75444 CD14 Protein, Mouse (HEK293, His-Fc) P10810/NP_033971.1 (S16-P345) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135750 VAF347 Agonist 99.90% 否
HY-N9965 2'-Fucosyllactose Inhibitor 99.95% 否
HY-101132 VB-201 / 否
HY-151399 Antimicrobial agent-5 Inhibitor / 否
HY-161901 BC-1293 Inhibitor / 否
HY-169067 10-Methoxy-canthin-6-one Activator / 否
HY-RS02189 CD14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd14 NCBI NCBI:929
Canis familiaris Cd14 NCBI NCBI:607076
Macaca fascicularis Cd14 NCBI NCBI:102129342
Leporidae Cd14 NCBI
Rattus norvegicus Cd14 NCBI NCBI:60350
Macaca mulatta Cd14 NCBI NCBI:697482
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