Yap1 - yes-associated protein 1 Gene

中文名称：是相关蛋白1

种属: Mus musculus

同用名: Yap; Yki; Yap65; Yorkie

关于 Yap1

功能概要

该基因编码的蛋白质与 Yes 原癌基因产物（一种酪氨酸激酶）的 SH3 结构域结合。该蛋白质包含一个 WW 结构域，由四个保守的芳香族氨基酸组成，包括两个色氨酸残基。这个保守的 WW 结构域存在于各种物种的各种结构、调节和信号分子中，并可能在蛋白质-蛋白质相互作用中发挥作用。细胞损伤后，这种编码蛋白的磷酸化可能会抑制细胞凋亡。这种蛋白质可能参与癌症的恶性转化。可变剪接导致多个转录本变体。 [RefSeq 提供，2010 年 1 月]

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic Amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress Apoptosis. This protein may be involved in malignant transformation in Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]