2. Gene
  3. Igf1 - insulin-like growth factor 1 Gene

Igf1 - insulin-like growth factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: IGF

基因 ID: 24482 | 基因类型: protein coding

关于 Igf1

功能概要

Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (Insulin like growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Igf1 基因产物(4)

mRNA Protein Name
NM_001082477.2 NP_001075946.2 insulin-like growth factor I isoform a preproprotein
NM_001082478.1 NP_001075947.1 insulin-like growth factor I isoform c preproprotein
NM_001082479.1 NP_001075948.1 insulin-like growth factor I isoform d preproprotein
NM_178866.4 NP_849197.3 insulin-like growth factor I isoform b preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IDA
IDA: 通过直接分析推断
16083987 RGD
enables insulin-like growth factor receptor binding IDA
IDA: 通过直接分析推断
16083987 RGD
enables protein serine/threonine kinase activator activity IDA
IDA: 通过直接分析推断
17023532 RGD
enables steroid binding IDA
IDA: 通过直接分析推断
16083987 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone development IEP
IEP: 通过表达模式推断
24735836 RGD
involved in cardiac atrium development IEP
IEP: 通过表达模式推断
15486038 RGD
involved in cellular response to Thyroglobulin triiodothyronine IEP
IEP: 通过表达模式推断
8674839 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
19853640 RGD
involved in cellular response to electrical stimulus IEP
IEP: 通过表达模式推断
18661273 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
17531559 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
20013160 RGD
involved in cellular response to nicotine IEP
IEP: 通过表达模式推断
23454400 RGD
involved in cellular response to progesterone stimulus IEP
IEP: 通过表达模式推断
19853640 RGD
involved in cellular response to zinc ion starvation IEP
IEP: 通过表达模式推断
21893222 RGD
involved in cranial suture morphogenesis IEP
IEP: 通过表达模式推断
10597685 RGD
involved in detection of mechanical stimulus involved in sensory perception IMP
IMP: 通过突变表型推断
21037532 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
17123939 RGD
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
16083987 RGD
involved in memory IMP
IMP: 通过突变表型推断
16650607 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
17103039 RGD
involved in negative regulation of cholangiocyte apoptotic process IMP
IMP: 通过突变表型推断
17531559 RGD
involved in negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
17023532 RGD
involved in negative regulation of immune system process IMP
IMP: 通过突变表型推断
8575560 RGD
involved in negative regulation of muscle cell apoptotic process IMP
IMP: 通过突变表型推断
16699953 RGD
involved in negative regulation of oligodendrocyte apoptotic process IDA
IDA: 通过直接分析推断
17577243 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: 通过突变表型推断
20724525 RGD
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
20724525 RGD
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: 通过遗传相互作用推断
28315330 RGD
involved in positive regulation of cell growth IDA
IDA: 通过直接分析推断
15544842 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
16869890 RGD
involved in positive regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
16897348 RGD
involved in positive regulation of glial cell proliferation IDA
IDA: 通过直接分析推断
24262632 RGD
involved in positive regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
16897348 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
17023532 RGD
involved in positive regulation of steroid hormone biosynthetic process IDA
IDA: 通过直接分析推断
17023532 RGD
involved in positive regulation of vascular endothelial cell proliferation IGI
IGI: 通过遗传相互作用推断
28315330 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
16763033 RGD
involved in regulation of cell population proliferation IDA
IDA: 通过直接分析推断
16083987 RGD
involved in regulation of translation IMP
IMP: 通过突变表型推断
15544842 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
19382144 RGD
involved in response to caffeine IEP
IEP: 通过表达模式推断
22995397 RGD
involved in response to epidermal growth factor IEP
IEP: 通过表达模式推断
2003595 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
11201330 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
17645580 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
24239160 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
19359918 RGD
involved in response to growth hormone IEP
IEP: 通过表达模式推断
21750148 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
19766709 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
19180987 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
11834488 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
23454400 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
2383530 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
17626604 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
19327374 RGD
involved in response to starvation IEP
IEP: 通过表达模式推断
7524339 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
15917159 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
8532765 RGD
involved in retinal cell apoptotic process IDA
IDA: 通过直接分析推断
10973501 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
15990634 RGD
located in interstitial matrix IDA
IDA: 通过直接分析推断
15544842 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21037532 RGD
located in platelet alpha granule IDA
IDA: 通过直接分析推断
9449625 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

insulin-like growth factor I

IGF-I

somatomedin

重组 Igf1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7203 IGF-I/IGF-1 Protein, Rat P08025 (G49-A118) ≥95%

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-15656 Ceritinib Inhibitor 99.98% 是
HY-15656A Ceritinib dihydrochloride Inhibitor 99.57% 是
HY-B0025 Voglibose Inhibitor ≥98.0% 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99165 Teprotumumab Inhibitor 99.46% 否
Clinical Phase
生物活性分子 (12)
目录号 产品名 作用方式
纯度 Phase
HY-10191 Linsitinib Inhibitor 99.84% Phase 3
HY-109155 Paltusotine Agonist 99.52% Phase 3
HY-15494 Picropodophyllin 99.85% Phase 2
HY-10200 BMS-754807 Inhibitor 99.41% Phase 2
HY-153485 Cimdelirsen Inhibitor / Phase 2
HY-153485A Cimdelirsen sodium Inhibitor / Phase 2
HY-15749 XL228 Inhibitor 99.64% Phase 1
HY-B0794B AZ7550 Mesylate Inhibitor 99.24% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-B0794A AZ7550 hydrochloride Inhibitor 98.66% Phase 1
HY-135749 BN201 / Phase 1
HY-114913 Fenarimol Inhibitor / Phase 1
抗体抑制剂 (8)
目录号 产品名 作用方式
纯度 Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P99197 Figitumumab Inhibitor 96.89% Phase 3
HY-P99274 Xentuzumab Antagonist 99.71% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P99218 Robatumumab Inhibitor 99.90% Phase 2
HY-P99712 Lonigutamab Inhibitor 95.00% Phase 2
HY-P99867 Dusigitumab 96.37% Phase 2
HY-P99672 Istiratumab Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (44)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108477 TMPyP4 tosylate Inhibitor ≥98.0% 否
HY-116624 MAZ51 99.96% 否
HY-50866 NVP-AEW541 99.92% 否
HY-10262 BMS-536924 99.83% 否
HY-15609 AZD-3463 99.58% 否
HY-10252 NVP-ADW742 99.54% 否
HY-N0908 Ginsenoside Rg5 99.87% 否
HY-10253 AG1024 98.86% 否
HY-10524 GSK1904529A 98.89% 否
HY-13203 NVP-TAE 226 99.77% 否
HY-W074890 Palmitoylglycine Modulator 99.74% 否
HY-100349 SU4312 Inhibitor 99.76% 否
HY-18785 Indirubin Derivative E804 Inhibitor 98.54% 否
HY-P2090A Angiopeptin TFA 99.71% 否
HY-145110 IGF-1R inhibitor-2 Inhibitor 98.36% 否
HY-135680 I-OMe-Tyrphostin AG 538 Inhibitor 98.03% 否
HY-RS06614 IGF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-139783 3-Campholenyl-2-butanol Inhibitor ≥98.0% 否
HY-135436 AG 538 Inhibitor 99.80% 否
HY-B0794 AZ7550 Inhibitor / 否
HY-125102 AZ12253801 Inhibitor / 否
HY-50866B NVP-AEW541 dihydrochloride / 否
HY-108230 ALK-IN-12 Inhibitor / 否
HY-118046 GSK2163632A Inhibitor / 否
HY-15494S1 Picropodophyllin-d6 / 否
HY-156914 IGF-1R/SRC-IN-1 Inhibitor 99.86% 否
HY-162506 IGF-1R inhibitor-3 Inhibitor / 否
HY-167854 KW-2450 free base / 否
HY-402309 IGF-1R modulator 1 Modulator / 否
HY-B0794S AZ7550-d5 Inhibitor / 否
HY-P2090 Angiopeptin / 否
HY-RS06615 IGF1R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06616 Igf1r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06617 Igf1r Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-100349A cis-SU4312 Inhibitor / 否
HY-109155A Paltusotine hydrochloride Agonist / 否
HY-117885 PF-5177624 Inhibitor / 否
HY-119112A LY 379196 Inhibitor / 否
HY-138257A (R)-Indeloxazine benzenesulfonate Inhibitor / 否
HY-14357 BMS 695735 Inhibitor / 否
HY-168616 CL-A3-7 Inhibitor / 否
HY-21291 SU-4313 Modulator / 否
HY-N6611 Chimaphilin Inhibitor / 否
HY-P3226 JB-1 Antagonist / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990084 Veligrotug Inhibitor 99.25% 否
HY-P991042 Anti-IGFBP2 Antibody (M14) Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Igf1 NCBI NCBI:3479
Macaca fascicularis Igf1 NCBI NCBI:102128018
Mus musculus Igf1 NCBI NCBI:16000
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